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Uterine corpus epithelioid leiomyosarcoma

MedGen UID:
274363
•Concept ID:
C1519851
•
Neoplastic Process
Synonyms: body of uterus epithelioid leiomyosarcoma; epithelioid leiomyosarcoma of body of uterus; Uterine Corpus Epithelioid Leiomyosarcoma; uterine corpus epithelioid leiomyosarcoma; uterine epithelioid leiomyosarcoma
 
Monarch Initiative: MONDO:0003782

Definition

A morphologic variant of leiomyosarcoma arising from the uterine corpus. It is characterized by the presence of epithelioid round cells with eosinophilic to clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus epithelioid leiomyosarcoma

Professional guidelines

PubMed

POTENTIAL DIAGNOSTIC BIOMARKERS FOR HUMAN MESENCHYMAL TUMORS, ESPECIALLY LMP2/Β1I AND CYCLIN E1/MIB1 DIFFERENTIAL EXPRESSION: PRUM-IBIO STUDY.
Tanabe Y, Hayashi T, Okada M, Aburatani H, Tonegawa S, Abiko K, Konishi I
Georgian Med News 2024 May;(350):42-48. PMID: 39089269
Sarcomas and related neoplasms of the uterine corpus--a brief review of their natural history, prognostic factors, and management.
Bard DS, Zuna RE
Obstet Gynecol Annu 1981;10:237-65. PMID: 6269035
Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Recent clinical studies

Etiology

Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Malignant tumors of the uterine corpus: molecular background of their origin.
Brany D, Dvorska D, Nachajova M, Slavik P, Burjanivova T
Tumour Biol 2015 Sep;36(9):6615-21. Epub 2015 Aug 26 doi: 10.1007/s13277-015-3824-1. PMID: 26307392
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
Malignant mesenchymal tumors of the uterine corpus.
Saksela E, Lampinen V, Procope BJ
Am J Obstet Gynecol 1974 Oct 15;120(4):452-60. doi: 10.1016/0002-9378(74)90620-6. PMID: 4370180

Diagnosis

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Carcinosarcoma of the corpus uteri (Malignant Müllerian Mixed Tumor): a case report in Yaoundé (Cameroon).
Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C
Pan Afr Med J 2013;16:145. Epub 2013 Dec 19 doi: 10.11604/pamj.2013.16.145.3497. PMID: 24876903Free PMC Article
Sarcomas and related neoplasms of the uterine corpus--a brief review of their natural history, prognostic factors, and management.
Bard DS, Zuna RE
Obstet Gynecol Annu 1981;10:237-65. PMID: 6269035

Therapy

Phase II study of niraparib in recurrent or persistent rare fraction of gynecologic malignancies with homologous recombination deficiency (JGOG2052).
Asano H, Oda K, Yoshihara K, Ito YM, Matsumura N, Shimada M, Watari H, Enomoto T
J Gynecol Oncol 2022 Jul;33(4):e55. Epub 2022 May 3 doi: 10.3802/jgo.2022.33.e55. PMID: 35557035Free PMC Article
CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.
Nakae R, Matsuzaki S, Serada S, Matsuo K, Shiomi M, Sato K, Nagase Y, Matsuzaki S, Nakagawa S, Hiramatsu K, Okazawa A, Kimura T, Egawa-Takata T, Kobayashi E, Ueda Y, Yoshino K, Naka T, Kimura T
Am J Obstet Gynecol 2021 Feb;224(2):197.e1-197.e23. Epub 2020 Aug 19 doi: 10.1016/j.ajog.2020.08.028. PMID: 32822640
Major clinical research advances in gynecologic cancer in 2015.
Suh DH, Kim M, Kim HJ, Lee KH, Kim JW
J Gynecol Oncol 2016 Nov;27(6):e53. doi: 10.3802/jgo.2016.27.e53. PMID: 27775259Free PMC Article
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Aminothiadiazole in the treatment of advanced leiomyosarcoma of the uterine corpus. A Gynecologic Oncology Group study.
Asbury R, Blessing JA, Smith DM, Carson LF
Am J Clin Oncol 1995 Oct;18(5):397-9. doi: 10.1097/00000421-199510000-00007. PMID: 7572755

Prognosis

Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Gynecological sarcomas.
DiSaia PJ, Pecorelli S
Semin Surg Oncol 1994 Sep-Oct;10(5):369-73. doi: 10.1002/ssu.2980100510. PMID: 7997731
Sarcomas and related neoplasms of the uterine corpus--a brief review of their natural history, prognostic factors, and management.
Bard DS, Zuna RE
Obstet Gynecol Annu 1981;10:237-65. PMID: 6269035
Malignant mesenchymal tumors of the uterine corpus.
Saksela E, Lampinen V, Procope BJ
Am J Obstet Gynecol 1974 Oct 15;120(4):452-60. doi: 10.1016/0002-9378(74)90620-6. PMID: 4370180

Clinical prediction guides

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Major clinical research advances in gynecologic cancer in 2015.
Suh DH, Kim M, Kim HJ, Lee KH, Kim JW
J Gynecol Oncol 2016 Nov;27(6):e53. doi: 10.3802/jgo.2016.27.e53. PMID: 27775259Free PMC Article
Major clinical research advances in gynecologic cancer in 2014.
Suh DH, Lee KH, Kim K, Kang S, Kim JW
J Gynecol Oncol 2015 Apr;26(2):156-67. doi: 10.3802/jgo.2015.26.2.156. PMID: 25872896Free PMC Article
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
Clinical and histopathological review of 24 cases of sarcoma of the corpus uteri.
Rendina GM, Donadio C, Fabri M, Orfei G, Rutigliano A, Saccucci P
Eur J Gynaecol Oncol 1984;5(2):140-5. PMID: 6723705

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