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Uterine corpus bizarre leiomyoma

MedGen UID:
275555
•Concept ID:
C1519853
•
Neoplastic Process
Synonyms: bizarre leiomyoma of body of uterus; body of uterus bizarre leiomyoma; Uterine Corpus Bizarre Leiomyoma; uterine corpus bizarre leiomyoma; Uterine Corpus Leiomyoma with Bizarre Nuclei; uterine corpus leiomyoma with bizarre nuclei; Uterine Corpus Leiomyoma, Atypical Variant; uterine corpus leiomyoma, atypical variant; Uterine Corpus Symplastic Leiomyoma; uterine corpus Symplastic leiomyoma
 
Monarch Initiative: MONDO:0001846

Definition

A morphologic variant of uterine corpus leiomyoma characterized by significant cytologic atypia. The atypical cells are large with pleomophic hyperchromatic nuclei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus bizarre leiomyoma

Recent clinical studies

Etiology

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573

Diagnosis

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573

Therapy

Fumarate Hydratase-Deficient Leiomyoma of the Uterine Corpus: Comparative Morphologic Analysis of Protein-Deficient Tumors With and Without Pathogenic Germline Fumarate Hydratase Gene Mutations.
Shi W, Liu Y, Aisagbonhi O, Roma AA, Hasteh F, Zare SY, Fadare O
Int J Surg Pathol 2024 Apr;32(2):340-355. Epub 2023 Jun 13 doi: 10.1177/10668969231180285. PMID: 37312573

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