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Vaginal Mucinous Adenocarcinoma

MedGen UID:
276951
•Concept ID:
C1519925
•
Neoplastic Process

Definition

A rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Mucinous Adenocarcinoma

Professional guidelines

PubMed

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Treatment failure in endometrial carcinoma.
Huang HJ, Tang YH, Chou HH, Yang LY, Chao A, Huang YT, Lin G, Liu FY, Chang TC, Lai CH
Int J Gynecol Cancer 2014 Jun;24(5):885-93. doi: 10.1097/IGC.0000000000000131. PMID: 24819657
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
Int J Gynecol Cancer 2011 Oct;21(7):1287-96. doi: 10.1097/IGC.0b013e31821f746c. PMID: 21685796

Recent clinical studies

Etiology

Non-human papilloma virus associated adenocarcinomas of the cervix uteri. Cytologic features and diagnostic agreement using whole slide digital cytology imaging.
Negri G, Macciocu E, Cepurnaite R, Kasal A, Troncone G, Steinkasserer M, Vittadello F
Diagn Cytopathol 2021 Feb;49(2):316-321. Epub 2020 Oct 29 doi: 10.1002/dc.24652. PMID: 33118707
American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review.
Harkenrider MM, Block AM, Alektiar KM, Gaffney DK, Jones E, Klopp A, Viswanathan AN, Small W Jr
Brachytherapy 2017 Jan-Feb;16(1):95-108. Epub 2016 May 31 doi: 10.1016/j.brachy.2016.04.005. PMID: 27260082Free PMC Article
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Local radiation therapy for localized relapsed or refractory ovarian cancer patients with or without symptoms after chemotherapy.
Fujiwara K, Suzuki S, Yoden E, Ishikawa H, Imajo Y, Kohno I
Int J Gynecol Cancer 2002 May-Jun;12(3):250-6. doi: 10.1046/j.1525-1438.2002.01096.x. PMID: 12060445

Diagnosis

Gastric-type glandular lesions of the female genital tract excluding the cervix: emerging pathological entities.
Wong RW, Talia KL, McCluggage WG
Histopathology 2024 Jul;85(1):20-39. Epub 2024 Mar 13 doi: 10.1111/his.15174. PMID: 38477341
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma.
Kato N, Toukairin M, Asanuma I, Motoyama T
Diagn Cytopathol 2007 Apr;35(4):193-7. doi: 10.1002/dc.20623. PMID: 17351940
Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa?
Dubé V, Lickrish GM, MacNeill KN, Colgan TJ
J Low Genit Tract Dis 2006 Jul;10(3):156-60. doi: 10.1097/00128360-200607000-00007. PMID: 16829755
Synchronous primary endometrial and ovarian cancer with three different histologic patterns: A case report.
Ree YS, Cho SH, Kim SR, Cho SH, Kim KT, Park MH
Int J Gynecol Cancer 2003 Sep-Oct;13(5):678-82. doi: 10.1046/j.1525-1438.2003.13382.x. PMID: 14675354

Therapy

American Brachytherapy Task Group Report: Adjuvant vaginal brachytherapy for early-stage endometrial cancer: A comprehensive review.
Harkenrider MM, Block AM, Alektiar KM, Gaffney DK, Jones E, Klopp A, Viswanathan AN, Small W Jr
Brachytherapy 2017 Jan-Feb;16(1):95-108. Epub 2016 May 31 doi: 10.1016/j.brachy.2016.04.005. PMID: 27260082Free PMC Article
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723
Metastatic cancer in sigmoid neovagina: a case report.
Lambert AE, Mukati M, Shobeiri SA
Female Pelvic Med Reconstr Surg 2013 Jan-Feb;19(1):56-7. doi: 10.1097/SPV.0b013e318278cc5d. PMID: 23321662
The fallopian tube: primary site of most pelvic high-grade serous carcinomas.
Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D
Int J Gynecol Cancer 2009 Jan;19(1):58-64. doi: 10.1111/IGC.0b013e318199009c. PMID: 19258943
Multimodality treatment of adenocarcinoma of the vagina Stage IV: potential for cure.
Abitbol A, Straus MJ, Sedlis A, Davidian M
Gynecol Oncol 1983 Oct;16(2):296-8. doi: 10.1016/0090-8258(83)90106-3. PMID: 6313495

Prognosis

Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging.
Kerwin CM, Markese M, Moroney MR, Smith LP, Patel NU
Abdom Radiol (NY) 2023 Feb;48(2):713-723. Epub 2022 Nov 5 doi: 10.1007/s00261-022-03724-w. PMID: 36334123
Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
Arakawa A, Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, Hirabayashi S, Hasegawa D, Manabe A, Ono K, Matsuoka M, Arai Y, Togashi Y, Shibata T, Nishikawa H, Aoki K, Yamamoto N, Kohno T, Ogawa C
N Engl J Med 2021 Jan 7;384(1):42-50. doi: 10.1056/NEJMoa2030391. PMID: 33406329
Vaginal metastasis of pancreatic cancer.
Benhayoune K, El Fatemi H, El Ghaouti M, Bannani A, Melhouf A, Harmouch T
Pan Afr Med J 2015;20:124. Epub 2015 Feb 12 doi: 10.11604/pamj.2015.20.124.5927. PMID: 26097628Free PMC Article
Symptomatic vaginal bleeding in a postmenopausal woman: a case report of pancreatic adenocarcinoma metastasizing exclusively to the vagina.
Fader AN, Brainard JA, Rose PG
Am J Obstet Gynecol 2007 Nov;197(5):e8-9. doi: 10.1016/j.ajog.2007.08.046. PMID: 17980174
Local radiation therapy for localized relapsed or refractory ovarian cancer patients with or without symptoms after chemotherapy.
Fujiwara K, Suzuki S, Yoden E, Ishikawa H, Imajo Y, Kohno I
Int J Gynecol Cancer 2002 May-Jun;12(3):250-6. doi: 10.1046/j.1525-1438.2002.01096.x. PMID: 12060445

Clinical prediction guides

Non-human papilloma virus associated adenocarcinomas of the cervix uteri. Cytologic features and diagnostic agreement using whole slide digital cytology imaging.
Negri G, Macciocu E, Cepurnaite R, Kasal A, Troncone G, Steinkasserer M, Vittadello F
Diagn Cytopathol 2021 Feb;49(2):316-321. Epub 2020 Oct 29 doi: 10.1002/dc.24652. PMID: 33118707
Impact of different adjuvant radiotherapy modalities on women with early-stage intermediate- to high-risk endometrial cancer.
Jin M, Hou X, Sun X, Zhang Y, Hu K, Zhang F
Int J Gynecol Cancer 2019 Oct;29(8):1264-1270. Epub 2019 Jul 17 doi: 10.1136/ijgc-2019-000317. PMID: 31320487
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723
Local radiation therapy for localized relapsed or refractory ovarian cancer patients with or without symptoms after chemotherapy.
Fujiwara K, Suzuki S, Yoden E, Ishikawa H, Imajo Y, Kohno I
Int J Gynecol Cancer 2002 May-Jun;12(3):250-6. doi: 10.1046/j.1525-1438.2002.01096.x. PMID: 12060445

Recent systematic reviews

Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.
Park DA, Lee DH, Kim SW, Lee SH
Eur J Surg Oncol 2016 Sep;42(9):1303-14. Epub 2016 Jun 29 doi: 10.1016/j.ejso.2016.06.400. PMID: 27439723

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