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Metastatic Bladder Paraganglioma

MedGen UID:
277328
•Concept ID:
C1334563
•
Neoplastic Process
Synonyms: Malignant Bladder Paraganglioma; Malignant Paraganglioma of Bladder; Malignant Paraganglioma of the Bladder; Malignant Paraganglioma of the Urinary Bladder; Malignant Paraganglioma of Urinary Bladder; Malignant Urinary Bladder Paraganglioma

Definition

An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Paraganglioma

Professional guidelines

PubMed

Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications.
Lopez-Beltran A, Cheng L
Hum Pathol 2006 Nov;37(11):1371-88. Epub 2006 Jul 31 doi: 10.1016/j.humpath.2006.05.009. PMID: 16949919
Malignant pheochromocytoma: diagnosis and treatment in fifteen cases.
Guo JZ, Gong LS, Chen SX, Luo BY, Xu MY
J Hypertens 1989 Apr;7(4):261-6. PMID: 2723428
Pheochromocytoma--recognition and management.
Ram CV, Engelman K
Curr Probl Cardiol 1979 Apr;4(1):1-37. doi: 10.1016/s0146-2806(79)80003-1. PMID: 42512

Recent clinical studies

Etiology

A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature.
Beilan JA, Lawton A, Hajdenberg J, Rosser CJ
BMC Urol 2013 Apr 29;13:22. doi: 10.1186/1471-2490-13-22. PMID: 23627260Free PMC Article
Surgical management of hereditary pheochromocytoma.
Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB
J Am Coll Surg 2004 Apr;198(4):525-34; discussion 534-5. doi: 10.1016/j.jamcollsurg.2003.12.001. PMID: 15051000
Experience with extra-adrenal pheochromocytoma.
Goldfarb DA, Novick AC, Bravo EL, Straffon RA, Montie JE, Kay R
J Urol 1989 Oct;142(4):931-6. doi: 10.1016/s0022-5347(17)38945-0. PMID: 2795745
Multiple endocrine neoplasia, type 2b.
Carney JA, Sizemore GW, Hayles AB
Pathobiol Annu 1978;8:105-53. PMID: 364372

Diagnosis

Primary well differentiated neuroendocrine tumor of the filum terminale. Case report and literature review.
Revuelta Barbero JM, Saab Mazzei A, Cotúa Quinteros C, de Reina L
Neurocirugia (Astur : Engl Ed) 2018 Sep-Oct;29(5):244-249. Epub 2017 Dec 30 doi: 10.1016/j.neucir.2017.11.002. PMID: 29295804
Paragangliomas: clinical overview.
Young WF Jr
Ann N Y Acad Sci 2006 Aug;1073:21-9. doi: 10.1196/annals.1353.002. PMID: 17102068
Surgical management of hereditary pheochromocytoma.
Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB
J Am Coll Surg 2004 Apr;198(4):525-34; discussion 534-5. doi: 10.1016/j.jamcollsurg.2003.12.001. PMID: 15051000
Extra-adrenal pheochromocytoma.
Whalen RK, Althausen AF, Daniels GH
J Urol 1992 Jan;147(1):1-10. doi: 10.1016/s0022-5347(17)37119-7. PMID: 1729490
Pheochromocytoma--recognition and management.
Ram CV, Engelman K
Curr Probl Cardiol 1979 Apr;4(1):1-37. doi: 10.1016/s0146-2806(79)80003-1. PMID: 42512

Therapy

Micturition syncope secondary to urinary bladder paraganglioma.
Johnson JT, Cherian KE, Kapoor N, Paul TV
BMJ Case Rep 2020 Mar 12;13(3) doi: 10.1136/bcr-2019-233556. PMID: 32169989Free PMC Article
A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Surgical management of hereditary pheochromocytoma.
Yip L, Lee JE, Shapiro SE, Waguespack SG, Sherman SI, Hoff AO, Gagel RF, Arens JF, Evans DB
J Am Coll Surg 2004 Apr;198(4):525-34; discussion 534-5. doi: 10.1016/j.jamcollsurg.2003.12.001. PMID: 15051000
Unusual locations of involvement by malignancies: Case 2. Metastatic pheochromocytoma to the colon.
Padmanabhan H, Ehrlich LD, Quazedo M, Fojo T, Louie A, Walther M, Pacak K
J Clin Oncol 2003 Sep 1;21(17):3369-71. doi: 10.1200/JCO.2003.09.100. PMID: 12947075
Pheochromocytoma--recognition and management.
Ram CV, Engelman K
Curr Probl Cardiol 1979 Apr;4(1):1-37. doi: 10.1016/s0146-2806(79)80003-1. PMID: 42512

Prognosis

A clinicopathological and immunohistochemical study of non-urothelial bladder tumours.
Kaur S, Gupta A, Gulwani HV
Indian J Cancer 2019 Jul-Sep;56(3):254-260. doi: 10.4103/ijc.IJC_459_17. PMID: 31389390
Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature.
Beilan JA, Lawton A, Hajdenberg J, Rosser CJ
BMC Urol 2013 Apr 29;13:22. doi: 10.1186/1471-2490-13-22. PMID: 23627260Free PMC Article
Extra-adrenal pheochromocytoma.
Whalen RK, Althausen AF, Daniels GH
J Urol 1992 Jan;147(1):1-10. doi: 10.1016/s0022-5347(17)37119-7. PMID: 1729490
Experience with extra-adrenal pheochromocytoma.
Goldfarb DA, Novick AC, Bravo EL, Straffon RA, Montie JE, Kay R
J Urol 1989 Oct;142(4):931-6. doi: 10.1016/s0022-5347(17)38945-0. PMID: 2795745
Pheochromocytoma--recognition and management.
Ram CV, Engelman K
Curr Probl Cardiol 1979 Apr;4(1):1-37. doi: 10.1016/s0146-2806(79)80003-1. PMID: 42512

Clinical prediction guides

First-in-Humans Application of (161)Tb: A Feasibility Study Using (161)Tb-DOTATOC.
Baum RP, Singh A, Kulkarni HR, Bernhardt P, Rydén T, Schuchardt C, Gracheva N, Grundler PV, Köster U, Müller D, Pröhl M, Zeevaart JR, Schibli R, van der Meulen NP, Müller C
J Nucl Med 2021 Oct;62(10):1391-1397. Epub 2021 Feb 5 doi: 10.2967/jnumed.120.258376. PMID: 33547209Free PMC Article
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics.
Dona M, Waaijers S, Richter S, Eisenhofer G, Korving J, Kamel SM, Bakkers J, Rapizzi E, Rodenburg RJ, Zethof J, Gorissen M, Flik G, Deen PMT, Timmers HJLM
Endocr Relat Cancer 2021 Jan;28(1):65-77. doi: 10.1530/ERC-20-0308. PMID: 33156815
Superficial siderosis of the central nervous system in a patient with asymptomatic sacral paraganglioma as source of chronic bleeding.
Prat-Acín R, Galeano-Senabre I, García-Sánchez D, Morales LL, Ayuso-Sacido A, Ferrer-Lozano J
Rev Neurol 2020 Oct 1;71(7):253-256. doi: 10.33588/rn.7107.2020215. PMID: 32959357
Primary well differentiated neuroendocrine tumor of the filum terminale. Case report and literature review.
Revuelta Barbero JM, Saab Mazzei A, Cotúa Quinteros C, de Reina L
Neurocirugia (Astur : Engl Ed) 2018 Sep-Oct;29(5):244-249. Epub 2017 Dec 30 doi: 10.1016/j.neucir.2017.11.002. PMID: 29295804
Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma.
Banzo J, Ubieto MA, Berisa MF, Andrés A, Mateo ML, Tardín L, Parra A, Razola P, Prats E
Rev Esp Med Nucl Imagen Mol 2013 Nov-Dec;32(6):397-9. Epub 2013 Jul 16 doi: 10.1016/j.remn.2013.05.005. PMID: 23867638

Recent systematic reviews

Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature.
Beilan JA, Lawton A, Hajdenberg J, Rosser CJ
BMC Urol 2013 Apr 29;13:22. doi: 10.1186/1471-2490-13-22. PMID: 23627260Free PMC Article

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