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Metastasizing Pleomorphic Adenoma of the Salivary Gland

MedGen UID:
277361
•Concept ID:
C1334711
•
Neoplastic Process
Synonyms: Metastasizing Mixed Tumor of Salivary Gland; Metastasizing Mixed Tumor of the Salivary Gland

Definition

A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features. The most common sites of metastasis are bone, lung, and head and neck. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastasizing Pleomorphic Adenoma of the Salivary Gland

Professional guidelines

PubMed

Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

Recent clinical studies

Etiology

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.
Tarsitano A, Foschini MP, Farneti P, Pasquini E, Marchetti C
J Craniomaxillofac Surg 2014 Dec;42(8):1562-5. Epub 2014 Jan 14 doi: 10.1016/j.jcms.2014.01.014. PMID: 24507933
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Imaging of salivary gland tumours.
Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Diagnosis

Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.
Tarsitano A, Foschini MP, Farneti P, Pasquini E, Marchetti C
J Craniomaxillofac Surg 2014 Dec;42(8):1562-5. Epub 2014 Jan 14 doi: 10.1016/j.jcms.2014.01.014. PMID: 24507933
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Parotid salivary duct carcinoma: a single institution's 20-year experience.
Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
Small cell carcinoma ex-pleomorphic adenoma of the parotid gland.
Cimino-Mathews A, Lin BM, Chang SS, Boahene KD, Bishop JA
Head Neck Pathol 2012 Dec;6(4):502-6. Epub 2012 Jun 27 doi: 10.1007/s12105-012-0376-1. PMID: 22736150Free PMC Article
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Chemotherapy for salivary gland cancer.
Kaplan MJ, Johns ME, Cantrell RW
Otolaryngol Head Neck Surg 1986 Sep;95(2):165-70. doi: 10.1177/019459988609500206. PMID: 3035459

Prognosis

Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Metastasizing "benign" pleomorphic salivary adenoma: a dramatic case-report and literature review.
Tarsitano A, Foschini MP, Farneti P, Pasquini E, Marchetti C
J Craniomaxillofac Surg 2014 Dec;42(8):1562-5. Epub 2014 Jan 14 doi: 10.1016/j.jcms.2014.01.014. PMID: 24507933
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Clinical prediction guides

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
High levels of ANXA2 are characteristic of malignant salivary gland tumors.
Cardoso CM, de Jesus SF, de Souza MG, Queiroz LDRP, Santos EM, Dos Santos EP, Oliveira LP, Cordeiro Santos CK, Santos SHS, de Paula AMB, Farias LC, Guimaraes ALS
J Oral Pathol Med 2019 Nov;48(10):929-934. Epub 2019 Aug 5 doi: 10.1111/jop.12932. PMID: 31325182
Histologic grading and prognostic biomarkers in salivary gland carcinomas.
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736
Metastasizing pleomorphic adenoma of the salivary gland.
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Metastasizing pleomorphic salivary adenoma.
Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191

Recent systematic reviews

Parotid incidentalomas: a systematic review.
Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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