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Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

MedGen UID:: 277363
•Concept ID:: C1334718
•: Neoplastic Process

Synonym:

Metastatic Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Definition

A small round cell tumor with or without neural differentiation that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Embryonal neoplasm
        Ewing sarcoma/peripheral primitive neuroectodermal tumor
        Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
        Metastatic Ewing Sarcoma
        Locally Advanced Ewing Sarcoma
        Metastatic Bone Ewing Sarcoma
        Metastatic Extraskeletal Ewing Sarcoma
        Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone

Professional guidelines

PubMed

Targeting B7-H3-A Novel Strategy for the Design of Anticancer Agents for Extracranial Pediatric Solid Tumors Treatment.

Rasic P, Jeremic M, Jeremic R, Dusanovic Pjevic M, Rasic M, Djuricic SM, Milickovic M, Vukadin M, Mijovic T, Savic D
Molecules 2023 Apr 11;28(8) doi: 10.3390/molecules28083356. PMID: 37110590 Free PMC Article

Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor.

Hayes FA, Thompson EI, Hvizdala E, O'Connor D, Green AA
J Pediatr 1984 Feb;104(2):221-4. doi: 10.1016/s0022-3476(84)80996-8. PMID: 6694014

Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors.

Triche TJ, Askin FB
Hum Pathol 1983 Jul;14(7):569-95. doi: 10.1016/s0046-8177(83)80202-0. PMID: 6345338

See all (10)

Recent clinical studies

Etiology

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA
Pediatr Blood Cancer 2023 Sep;70 Suppl 6(Suppl 6):e30583. Epub 2023 Jul 27 doi: 10.1002/pbc.30583. PMID: 37501549 Free PMC Article

Small cell tumors of bone.

Li S, Siegal GP
Adv Anat Pathol 2010 Jan;17(1):1-11. doi: 10.1097/PAP.0b013e3181bb6b9c. PMID: 20032633

Ewing's sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands.

Smorenburg CH, van Groeningen CJ, Meijer OW, Visser M, Boven E
Neth J Med 2007 Apr;65(4):132-6. PMID: 17452761

Ewing tumor: tumor biology and clinical applications.

de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Pediatric applications in nuclear oncology.

Sty JR, Kun LE, Starshak RJ
Semin Nucl Med 1985 Apr;15(2):171-200. doi: 10.1016/s0001-2998(85)80025-8. PMID: 2988131

See all (55)

Diagnosis

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor in the Adrenal Gland of a Child.

Goudarzipour K, Farahmandi F, Mohammadi A, Taherian R
Iran J Kidney Dis 2018 May;12(3):190-192. PMID: 29891750

Small cell tumors of bone.

Li S, Siegal GP
Adv Anat Pathol 2010 Jan;17(1):1-11. doi: 10.1097/PAP.0b013e3181bb6b9c. PMID: 20032633

Ewing tumor: tumor biology and clinical applications.

de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Pediatric applications in nuclear oncology.

Sty JR, Kun LE, Starshak RJ
Semin Nucl Med 1985 Apr;15(2):171-200. doi: 10.1016/s0001-2998(85)80025-8. PMID: 2988131

See all (103)

Therapy

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Targeting B7-H3-A Novel Strategy for the Design of Anticancer Agents for Extracranial Pediatric Solid Tumors Treatment.

Adult Primary Peripheral PNET/Ewing's Sarcoma of the Cervical and Thoracic Spine.

Khwaja R, Mantilla E, Fink K, Pan E
Anticancer Res 2019 Aug;39(8):4463-4465. doi: 10.21873/anticanres.13619. PMID: 31366545

Ewing's sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands.

Smorenburg CH, van Groeningen CJ, Meijer OW, Visser M, Boven E
Neth J Med 2007 Apr;65(4):132-6. PMID: 17452761

Ewing's sarcoma and extracranial peripheral neuroectodermal tumors.

Granowetter L
Curr Opin Oncol 1995 Jul;7(4):355-60. doi: 10.1097/00001622-199507000-00011. PMID: 7578384

See all (43)

Prognosis

Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.

Souza BK, Freire NH, Monteiro TS, Herlinger AL, Jaeger M, Dalmolin MGS, de Farias CB, Gregianin L, Brunetto AT, Brunetto AL, Thiele CJ, Roesler R
Int J Mol Sci 2023 Oct 17;24(20) doi: 10.3390/ijms242015242. PMID: 37894922 Free PMC Article

Primary intracranial Ewing sarcoma/ peripheral primitive neuroectodermal tumor, an entity of unacquaintance: a series of 8 cases.

Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378

Extraosseous Ewing sarcoma and peripheral primitive neuroectodermal tumor of the thyroid gland: Case report and review.

Chirila M, Muresan M, Ciuleanu E, Cosgarea M
Ear Nose Throat J 2013 Apr-May;92(4-5):E3-6. doi: 10.1177/014556131309200419. PMID: 23599116

Malignant osseous tumors of the pediatric spine.

Kim HJ, McLawhorn AS, Goldstein MJ, Boland PJ
J Am Acad Orthop Surg 2012 Oct;20(10):646-56. doi: 10.5435/JAAOS-20-10-646. PMID: 23027694

Ewing tumor: tumor biology and clinical applications.

de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

See all (65)

Clinical prediction guides

A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.

Saulnier-Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK
Clin Cancer Res 2022 Sep 15;28(18):3950-3957. doi: 10.1158/1078-0432.CCR-22-1169. PMID: 35833850 Free PMC Article

Primary intracranial Ewing's sarcoma with unusual features.

VandenHeuvel KA, Al-Rohil RN, Stevenson ME, Qian J, Gross NL, McNall-Knapp R, Li S, Wartchow EP, Mierau GW, Fung KM
Int J Clin Exp Pathol 2015;8(1):260-74. Epub 2015 Jan 1 PMID: 25755713 Free PMC Article

Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement.

Applebaum MA, Goldsby R, Neuhaus J, DuBois SG
Pediatr Blood Cancer 2012 Oct;59(4):617-20. Epub 2011 Dec 19 doi: 10.1002/pbc.24053. PMID: 22184129 Free PMC Article

Adult soft tissue Ewing sarcoma or primitive neuroectodermal tumors: predictors of survival?

Martin RC 2nd, Brennan MF
Arch Surg 2003 Mar;138(3):281-5. doi: 10.1001/archsurg.138.3.281. PMID: 12611575

Cytogenetic analysis in the examination of solid tumors in children.

Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009

See all (36)

Recent systematic reviews

Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review.

Hajsadeghi S, Iranpour A, Amouei E, Tehrani NH, Ghavidel A, Ziaie H, Asadi O, Moradians V, Tayebi A, Mestres CA, Manqoutaei SA
Asian Cardiovasc Thorac Ann 2022 Sep;30(7):761-771. Epub 2022 Mar 21 doi: 10.1177/02184923221083434. PMID: 35306869

(18) F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis.

Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700

See all (2)

MedGen

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Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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