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Eosinophilic pneumonia

MedGen UID:
282904
•Concept ID:
C1527407
•
Disease or Syndrome
Synonym: Loeffler syndrome
 
HPO: HP:0032071
Monarch Initiative: MONDO:0005749

Definition

The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia. [from HPO]

Professional guidelines

PubMed

Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Recent clinical studies

Etiology

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Smoking-related interstitial lung disease.
Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Smoking-associated interstitial lung disease: update and review.
Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511
Eosinophilic Pneumonias.
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405

Diagnosis

Eosinophilic Lung Diseases.
Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477
Eosinophilic Lung Diseases.
Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599

Therapy

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Smoking-related interstitial lung disease.
Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Eosinophilic Pneumonias.
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405

Prognosis

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Eosinophilic Pneumonias.
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477
Pulmonary eosinophilia.
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481

Clinical prediction guides

Eosinophilia Induced by Blocking the IL-4/IL-13 Pathway: Potential Mechanisms and Clinical Outcomes.
Olaguibel JM, Sastre J, Rodríguez JM, Del Pozo V
J Investig Allergol Clin Immunol 2022 Jun 20;32(3):165-180. Epub 2022 May 6 doi: 10.18176/jiaci.0823. PMID: 35522053
Drug-induced eosinophilic pneumonia: A review of 196 case reports.
Bartal C, Sagy I, Barski L
Medicine (Baltimore) 2018 Jan;97(4):e9688. doi: 10.1097/MD.0000000000009688. PMID: 29369189Free PMC Article
Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials.
Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, Yokoyama A, Olsson J, Gray S, Holweg CT, Eisner M, Asare C, Fischer SK, Peng K, Putnam WS, Matthews JG
Lancet Respir Med 2016 Oct;4(10):781-796. Epub 2016 Sep 5 doi: 10.1016/S2213-2600(16)30265-X. PMID: 27616196
Amiodarone: review of pulmonary effects and toxicity.
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056
Clarithromycin-induced eosinophilic pneumonia.
Ohnishi H, Abe M, Yokoyama A, Hamada H, Ito R, Hirayama T, Nishimura K, Higaki J
Intern Med 2004 Mar;43(3):231-5. doi: 10.2169/internalmedicine.43.231. PMID: 15098607

Recent systematic reviews

Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review.
Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L
Chemotherapy 2024;69(2):85-99. Epub 2023 Nov 14 doi: 10.1159/000535190. PMID: 37963447
COVID-19 mimics on chest CT: a pictorial review and radiologic guide.
Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, Verma N, Meirelles GSP, Marchiori E
Br J Radiol 2021 Feb 1;94(1118):20200703. Epub 2020 Dec 9 doi: 10.1259/bjr.20200703. PMID: 33296607Free PMC Article
The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis.
Akiyama S, Yamada A, Micic D, Sakuraba A
J Am Acad Dermatol 2021 Mar;84(3):676-690. Epub 2020 Aug 11 doi: 10.1016/j.jaad.2020.08.026. PMID: 32791083Free PMC Article
Acute eosinophilic pneumonia associated with non-cigarette smoking products: a systematic review.
Chaaban T
Adv Respir Med 2020;88(2):142-146. doi: 10.5603/ARM.2020.0088. PMID: 32383466

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