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Krebs 2 carcinoma

MedGen UID:
2842
•Concept ID:
C0007128
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Carcinoma, Krebs 2; Krebs 2 Carcinoma
 
Monarch Initiative: MONDO:0006824

Definition

Carcinoma having known association to krebs2 gene mutation [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKrebs 2 carcinoma

Recent clinical studies

Etiology

The New General Biological Property of Stem-like Tumor Cells (Part II: Surface Molecules, Which Belongs to Distinctive Groups with Particular Functions, Form a Unique Pattern Characteristic of a Certain Type of Tumor Stem-like Cells).
Petrova DD, Dolgova EV, Proskurina AS, Ritter GS, Ruzanova VS, Efremov YR, Potter EA, Kirikovich SS, Levites EV, Taranov OS, Ostanin AA, Chernykh ER, Kolchanov NA, Bogachev SS
Int J Mol Sci 2022 Dec 13;23(24) doi: 10.3390/ijms232415800. PMID: 36555446Free PMC Article
Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent.
Godovikova TS, Lisitskiy VA, Antonova NM, Popova TV, Zakharova OD, Chubarov AS, Koptyug IV, Sagdeev RZ, Kaptein R, Akulov AE, Kaledin VI, Nikolin VP, Baiborodin SI, Koroleva LS, Silnikov VN
Bioconjug Chem 2013 May 15;24(5):780-95. Epub 2013 Apr 16 doi: 10.1021/bc3006072. PMID: 23521072

Diagnosis

A strategy to eradicate well-developed Krebs-2 ascites in mice.
Potter EA, Dolgova EV, Proskurina AS, Minkevich AM, Efremov YR, Taranov OS, Omigov VV, Nikolin VP, Popova NA, Bayborodin SI, Ostanin AA, Chernykh ER, Kolchanov NA, Shurdov MA, Bogachev SS
Oncotarget 2016 Mar 8;7(10):11580-94. doi: 10.18632/oncotarget.7311. PMID: 26872383Free PMC Article
Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent.
Godovikova TS, Lisitskiy VA, Antonova NM, Popova TV, Zakharova OD, Chubarov AS, Koptyug IV, Sagdeev RZ, Kaptein R, Akulov AE, Kaledin VI, Nikolin VP, Baiborodin SI, Koroleva LS, Silnikov VN
Bioconjug Chem 2013 May 15;24(5):780-95. Epub 2013 Apr 16 doi: 10.1021/bc3006072. PMID: 23521072
Inhibition of asparagine-linked glycosylation by incorporation of a threonine analog into nascent peptide chains.
Hortin G, Boime I
J Biol Chem 1980 Sep 10;255(17):8007-10. PMID: 6773934
Isolation and characterization of a ribonuclease activity specific for double-stranded RNA (RNase D) from Krebs II ascites cells.
Rech J, Cathala G, Jeanteur P
J Biol Chem 1980 Jul 25;255(14):6700-6. PMID: 6248530

Therapy

A strategy to eradicate well-developed Krebs-2 ascites in mice.
Potter EA, Dolgova EV, Proskurina AS, Minkevich AM, Efremov YR, Taranov OS, Omigov VV, Nikolin VP, Popova NA, Bayborodin SI, Ostanin AA, Chernykh ER, Kolchanov NA, Shurdov MA, Bogachev SS
Oncotarget 2016 Mar 8;7(10):11580-94. doi: 10.18632/oncotarget.7311. PMID: 26872383Free PMC Article
Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent.
Godovikova TS, Lisitskiy VA, Antonova NM, Popova TV, Zakharova OD, Chubarov AS, Koptyug IV, Sagdeev RZ, Kaptein R, Akulov AE, Kaledin VI, Nikolin VP, Baiborodin SI, Koroleva LS, Silnikov VN
Bioconjug Chem 2013 May 15;24(5):780-95. Epub 2013 Apr 16 doi: 10.1021/bc3006072. PMID: 23521072
The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth.
Pryme IF, Pusztai A, Bardocz S, Ewen SW
Histol Histopathol 1998 Apr;13(2):575-83. doi: 10.14670/HH-13.575. PMID: 9589910
Switching between control and phytohaemagglutinin-containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine.
Pryme IF, Bardocz S, Grant G, Duguid TJ, Brown DS, Pusztai A
Cancer Lett 1995 Jul 13;93(2):233-7. doi: 10.1016/0304-3835(95)03815-e. PMID: 7621434

Prognosis

Comparison of phosphorylation of ribosomal proteins from HeLa and Krebs II ascites-tumour cells by cyclic AMP-dependent and cyclic GMP-dependent protein kinases.
Issinger OG, Beier H, Speichermann N, Flokerzi V, Hofmann F
Biochem J 1980 Jan 1;185(1):89-99. doi: 10.1042/bj1850089. PMID: 6246882Free PMC Article

Clinical prediction guides

Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent.
Godovikova TS, Lisitskiy VA, Antonova NM, Popova TV, Zakharova OD, Chubarov AS, Koptyug IV, Sagdeev RZ, Kaptein R, Akulov AE, Kaledin VI, Nikolin VP, Baiborodin SI, Koroleva LS, Silnikov VN
Bioconjug Chem 2013 May 15;24(5):780-95. Epub 2013 Apr 16 doi: 10.1021/bc3006072. PMID: 23521072
The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth.
Pryme IF, Pusztai A, Bardocz S, Ewen SW
Histol Histopathol 1998 Apr;13(2):575-83. doi: 10.14670/HH-13.575. PMID: 9589910
Unusual requirements for optimum translation of polio viral RNA in vitro.
Daniels-McQueen S, Detjen BM, Grifo JA, Merrick WC, Thach RE
J Biol Chem 1983 Jun 10;258(11):7195-9. PMID: 6304083
DL-threo-beta-fluoroasparagine inhibits asparagine-linked glycosylation in cell-free lysates.
Hortin G, Stern AM, Miller B, Abeles RH, Boime I
J Biol Chem 1983 Apr 10;258(7):4047-50. PMID: 6187733
Membrane-dependent cleavage of the human placental lactogen precursor to its native form in ascites cell-free extracts.
Boime I, Szczesna E, Smith D
Eur J Biochem 1977 Mar 1;73(2):515-20. doi: 10.1111/j.1432-1033.1977.tb11345.x. PMID: 849746

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