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Digestive System Carcinoma In Situ

MedGen UID:
284246
•Concept ID:
C1542107
•
Neoplastic Process
Synonym: Gastrointestinal System Carcinoma In Situ

Definition

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Carcinoma In Situ

Professional guidelines

PubMed

Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Recent clinical studies

Etiology

Adenosquamous carcinoma in situ of the anus: a case series.
Keske A, Weisman PS, Xu J
Virchows Arch 2023 Jun;482(6):993-997. Epub 2023 Apr 1 doi: 10.1007/s00428-023-03525-6. PMID: 37004554
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM
Proc Natl Acad Sci U S A 2016 Mar 15;113(11):3078-83. Epub 2016 Feb 29 doi: 10.1073/pnas.1512603113. PMID: 26929329Free PMC Article
Anal intraepitelial neoplasia: A narrative review.
Elorza G, Saralegui Y, Enríquez-Navascués JM, Placer C, Velaz L
Rev Esp Enferm Dig 2016 Jan;108(1):31-9. PMID: 26765233
Hereditary gastric cancer.
Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

Diagnosis

Gene fusions in gastrointestinal tract cancers.
Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Anal intraepitelial neoplasia: A narrative review.
Elorza G, Saralegui Y, Enríquez-Navascués JM, Placer C, Velaz L
Rev Esp Enferm Dig 2016 Jan;108(1):31-9. PMID: 26765233
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Therapy

Phase II study (KAMELEON) of single-agent T-DM1 in patients with HER2-positive advanced urothelial bladder cancer or pancreatic cancer/cholangiocarcinoma.
de Vries EGE, Rüschoff J, Lolkema M, Tabernero J, Gianni L, Voest E, de Groot DJA, Castellano D, Erb G, Naab J, Donica M, Deurloo R, van der Heijden MS, Viale G
Cancer Med 2023 Jun;12(11):12071-12083. Epub 2023 Apr 29 doi: 10.1002/cam4.5893. PMID: 37119523Free PMC Article
Clonally expanded EOMES(+) Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M
Nat Immunol 2021 Jun;22(6):735-745. Epub 2021 May 20 doi: 10.1038/s41590-021-00930-4. PMID: 34017124
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.
Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM
Proc Natl Acad Sci U S A 2016 Mar 15;113(11):3078-83. Epub 2016 Feb 29 doi: 10.1073/pnas.1512603113. PMID: 26929329Free PMC Article
Case-control study of human papillomavirus and oropharyngeal cancer.
D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
N Engl J Med 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497. PMID: 17494927
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.
Saviano A, Henderson NC, Baumert TF
J Hepatol 2020 Nov;73(5):1219-1230. Epub 2020 Jun 10 doi: 10.1016/j.jhep.2020.06.004. PMID: 32534107Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Duodenal villous tumors.
Bjork KJ, Davis CJ, Nagorney DM, Mucha P Jr
Arch Surg 1990 Aug;125(8):961-5. doi: 10.1001/archsurg.1990.01410200019001. PMID: 2378560

Clinical prediction guides

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
Role and mechanism of circ-PRKCI in hepatocellular carcinoma.
Qi SX, Sun H, Liu H, Yu J, Jiang ZY, Yan P
World J Gastroenterol 2019 Apr 28;25(16):1964-1974. doi: 10.3748/wjg.v25.i16.1964. PMID: 31086464Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Practising high-resolution anoscopy.
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: a systematic review and meta-analysis.
Suzuki R, Thosani N, Annangi S, Guha S, Bhutani MS
Pancreatology 2014 Sep-Oct;14(5):380-4. Epub 2014 Jul 22 doi: 10.1016/j.pan.2014.07.006. PMID: 25278308
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis.
Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE
Lancet Oncol 2012 May;13(5):487-500. Epub 2012 Mar 23 doi: 10.1016/S1470-2045(12)70080-3. PMID: 22445259

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