U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Endometrioid adenocarcinoma

MedGen UID:
293976
•Concept ID:
C1569637
•
Neoplastic Process
Synonyms: Adenocarcinoma, Endometrioid; Adenocarcinomas, Endometrioid; Endometrioid Adenocarcinoma; Endometrioid Adenocarcinomas
SNOMED CT: Endometrioid adenocarcinoma (30289006); Endometrioid cystadenocarcinoma (30289006)
 
Monarch Initiative: MONDO:0005026

Definition

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Endometrioid adenocarcinoma

Professional guidelines

PubMed

The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma.
Ray-Coquard I, Monk BJ, Lorusso D, Mahdi H, Upadhyay V, Graul R, Husain A, Mirza MR, Slomovitz B
Int J Gynecol Cancer 2023 Dec 4;33(12):1943-1949. doi: 10.1136/ijgc-2023-004739. PMID: 37907262Free PMC Article
Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
Challenges and controversies in the conservative management of uterine and ovarian cancer.
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

Recent clinical studies

Etiology

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256
The role of radiation therapy in locally advanced endometrial cancer.
Anderson PR
Semin Radiat Oncol 2006 Jul;16(3):152-7. doi: 10.1016/j.semradonc.2006.02.003. PMID: 16814155

Diagnosis

Endometrioid adenocarcinoma with sacral metastasis.
Gontijo LC, Etchebehere RM, Ferreira de Souza LRM, Candido Murta EF, Simões Nomelini R
Ceska Gynekol 2024;89(4):298-303. doi: 10.48095/cccg2024298. PMID: 39242205
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial hyperplasia.
Mills AM, Longacre TA
Semin Diagn Pathol 2010 Nov;27(4):199-214. doi: 10.1053/j.semdp.2010.09.002. PMID: 21309256

Therapy

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Recurrence of endometrial carcinoma presenting as vulvar lesions.
Rottenstreich M, Armon S, Beller U, Rosengarten O, Vernea F, Reichman O
Int J Gynaecol Obstet 2019 Apr;145(1):123-124. Epub 2019 Feb 6 doi: 10.1002/ijgo.12762. PMID: 30653661
Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives.
Mabuchi S, Sugiyama T, Kimura T
J Gynecol Oncol 2016 May;27(3):e31. doi: 10.3802/jgo.2016.27.e31. PMID: 27029752Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrial cancer chemoprevention: implications of diverse pathways of carcinogenesis.
Sherman ME, Sturgeon S, Brinton L, Kurman RJ
J Cell Biochem Suppl 1995;23:160-4. doi: 10.1002/jcb.240590921. PMID: 8747391

Prognosis

Endometrioid adenocarcinoma with sacral metastasis.
Gontijo LC, Etchebehere RM, Ferreira de Souza LRM, Candido Murta EF, Simões Nomelini R
Ceska Gynekol 2024;89(4):298-303. doi: 10.48095/cccg2024298. PMID: 39242205
Diagnostic performance of intraoperative assessment in grade 2 endometrioid endometrial carcinoma.
Bandala-Jacques A, Cantú-de-León D, Pérez-Montiel D, Salcedo-Hernández RA, Prada D, González-Enciso A, Gonzalez-Valdés A, Barquet-Muñoz SA
World J Surg Oncol 2020 Oct 30;18(1):284. doi: 10.1186/s12957-020-02056-7. PMID: 33126895Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523
Endometrioid adenocarcinoma arising from adenomyosis.
Takai N, Akizuki S, Nasu K, Etoh Y, Miyakawa I
Gynecol Obstet Invest 1999;48(2):141-4. doi: 10.1159/000010139. PMID: 10461008

Clinical prediction guides

Endometrioid adenocarcinoma with sacral metastasis.
Gontijo LC, Etchebehere RM, Ferreira de Souza LRM, Candido Murta EF, Simões Nomelini R
Ceska Gynekol 2024;89(4):298-303. doi: 10.48095/cccg2024298. PMID: 39242205
Clinical and multiparametric MRI features for differentiating uterine carcinosarcoma from endometrioid adenocarcinoma.
Chen X, Guo Q, Chen X, Zheng W, Kang Y, Cao D
BMC Med Imaging 2024 Feb 19;24(1):48. doi: 10.1186/s12880-024-01225-4. PMID: 38373912Free PMC Article
Diagnostic performance of intraoperative assessment in grade 2 endometrioid endometrial carcinoma.
Bandala-Jacques A, Cantú-de-León D, Pérez-Montiel D, Salcedo-Hernández RA, Prada D, González-Enciso A, Gonzalez-Valdés A, Barquet-Muñoz SA
World J Surg Oncol 2020 Oct 30;18(1):284. doi: 10.1186/s12957-020-02056-7. PMID: 33126895Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565

Recent systematic reviews

Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Complexity of glandular architecture should be reconsidered in the classification and management of endometrial hyperplasia.
Travaglino A, Raffone A, Saccone G, Mollo A, De Placido G, Mascolo M, Insabato L, Zullo F
APMIS 2019 Jun;127(6):427-434. Epub 2019 Mar 19 doi: 10.1111/apm.12945. PMID: 30802329
Endometriosis-associated malignant transformation in abdominal surgical scar: A PRISMA-compliant systematic review.
Mihailovici A, Rottenstreich M, Kovel S, Wassermann I, Smorgick N, Vaknin Z
Medicine (Baltimore) 2017 Dec;96(49):e9136. doi: 10.1097/MD.0000000000009136. PMID: 29245355Free PMC Article
A case of ovarian adenosquamous carcinoma arising from endometrioid adenocarcinoma: a case report and systematic review.
Shoji T, Takatori E, Murakami K, Kaido Y, Takeuchi S, Kikuchi A, Sugiyama T
J Ovarian Res 2016 Aug 11;9(1):48. doi: 10.1186/s13048-016-0255-6. PMID: 27514842Free PMC Article
Laparoscopy versus laparotomy for the management of early stage endometrial cancer.
Galaal K, Bryant A, Fisher AD, Al-Khaduri M, Kew F, Lopes AD
Cochrane Database Syst Rev 2012 Sep 12;(9):CD006655. doi: 10.1002/14651858.CD006655.pub2. PMID: 22972096

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer, 2024

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...