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Aphasia, Wernicke

MedGen UID:
307140
•Concept ID:
C1510456
•
Mental or Behavioral Dysfunction
Synonyms: Aphasia, Wernicke's Fluent; Aphasias, Wernicke; Dysphasia, Wernicke; Dysphasia, Wernicke's; Dysphasia, Wernickes; Fluent Aphasia, Wernicke; Fluent Aphasia, Wernicke's; Fluent Aphasia, Wernickes; Wernicke Aphasia; Wernicke Aphasias; Wernicke Dysphasia; Wernicke's Dysphasia; Wernicke's Fluent Aphasia

Definition

Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke''s area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAphasia, Wernicke

Professional guidelines

PubMed

Drug treatment of poststroke aphasia.
Bakheit AM
Expert Rev Neurother 2004 Mar;4(2):211-7. doi: 10.1586/14737175.4.2.211. PMID: 15853562
Stroke and neurodegenerative disorders. 3. Stroke: rehabilitation management.
Bogey RA, Geis CC, Bryant PR, Moroz A, O'neill BJ
Arch Phys Med Rehabil 2004 Mar;85(3 Suppl 1):S15-20. doi: 10.1053/j.apmr.2003.11.011. PMID: 15034852
Effects of speech and language treatment on recovery from aphasia.
Shewan CM, Kertesz A
Brain Lang 1984 Nov;23(2):272-99. doi: 10.1016/0093-934x(84)90068-3. PMID: 6083819

Recent clinical studies

Etiology

Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia.
Vuković M, Vuković I, Miller N
J Commun Disord 2016 May-Jun;61:106-118. Epub 2016 Apr 11 doi: 10.1016/j.jcomdis.2016.04.005. PMID: 27135368
Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
Thompson HE, Robson H, Lambon Ralph MA, Jefferies E
Brain 2015 Dec;138(Pt 12):3776-92. Epub 2015 Oct 9 doi: 10.1093/brain/awv281. PMID: 26454668Free PMC Article
Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles.
Ogar JM, Baldo JV, Wilson SM, Brambati SM, Miller BL, Dronkers NF, Gorno-Tempini ML
Brain Lang 2011 Apr;117(1):28-33. Epub 2011 Feb 18 doi: 10.1016/j.bandl.2010.11.004. PMID: 21315437Free PMC Article
Word order and finiteness in Dutch and English Broca's and Wernicke's aphasia.
Bastiaanse R, Edwards S
Brain Lang 2004 Apr;89(1):91-107. doi: 10.1016/S0093-934X(03)00306-7. PMID: 15010241
Picture-naming in aphasia.
Kohn SE, Goodglass H
Brain Lang 1985 Mar;24(2):266-83. doi: 10.1016/0093-934x(85)90135-x. PMID: 3978406

Diagnosis

Subcortical aphasia.
Nadeau SE, Crosson B
Brain Lang 1997 Jul;58(3):355-402; discussion 418-23. doi: 10.1006/brln.1997.1707. PMID: 9222518
Thalamic aphasia syndrome.
Ozeren A, Sarica Y, Efe R
Acta Neurol Belg 1994;94(3):205-8. PMID: 7526590
Clinical forms of aphasia.
Kertesz A
Acta Neurochir Suppl (Wien) 1993;56:52-8. doi: 10.1007/978-3-7091-9239-9_9. PMID: 8498201
Perseveration in aphasia.
Albert ML, Sandson J
Cortex 1986 Mar;22(1):103-15. doi: 10.1016/s0010-9452(86)80035-1. PMID: 2423294
Picture-naming in aphasia.
Kohn SE, Goodglass H
Brain Lang 1985 Mar;24(2):266-83. doi: 10.1016/0093-934x(85)90135-x. PMID: 3978406

Therapy

Category specific recall in acute stroke: a case with letter speech.
De Letter M, Van Borsel J, Lanckmans E, Batens K, Hemelsoet D, Duyck W, Fias W, Santens P
Neurocase 2019 Dec;25(6):251-258. Epub 2019 Oct 1 doi: 10.1080/13554794.2019.1673440. PMID: 31571518
Deciphering the mechanisms of phonological therapy in jargon aphasia.
Bose A, Höbler F, Saddy D
Int J Lang Commun Disord 2019 Jan;54(1):123-142. Epub 2018 Nov 26 doi: 10.1111/1460-6984.12437. PMID: 30474174Free PMC Article
Constraint-induced aphasia therapy versus intensive semantic treatment in fluent aphasia.
Wilssens I, Vandenborre D, van Dun K, Verhoeven J, Visch-Brink E, Mariën P
Am J Speech Lang Pathol 2015 May;24(2):281-94. doi: 10.1044/2015_AJSLP-14-0018. PMID: 25765602
Phonological therapy in jargon aphasia: effects on naming and neologisms.
Bose A
Int J Lang Commun Disord 2013 Sep-Oct;48(5):582-95. Epub 2013 Jul 11 doi: 10.1111/1460-6984.12038. PMID: 24033655
Negotiation of identity in group therapy for aphasia: the Aphasia Café.
Simmons-Mackie N, Elman RJ
Int J Lang Commun Disord 2011 May-Jun;46(3):312-23. doi: 10.3109/13682822.2010.507616. PMID: 21575072

Prognosis

The memory for words: Armand Trousseau on aphasia.
Leblanc R
J Hist Neurosci 2022 Jan-Mar;31(1):1-19. Epub 2021 Jun 11 doi: 10.1080/0964704X.2021.1898909. PMID: 34115961
The Relationship Between Confrontation Naming and Story Gist Production in Aphasia.
Richardson JD, Dalton SG, Fromm D, Forbes M, Holland A, MacWhinney B
Am J Speech Lang Pathol 2018 Mar 1;27(1S):406-422. doi: 10.1044/2017_AJSLP-16-0211. PMID: 29497752Free PMC Article
Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
Thompson HE, Robson H, Lambon Ralph MA, Jefferies E
Brain 2015 Dec;138(Pt 12):3776-92. Epub 2015 Oct 9 doi: 10.1093/brain/awv281. PMID: 26454668Free PMC Article
Acquired aphasia in children.
Rapin I
J Child Neurol 1995 Jul;10(4):267-70. doi: 10.1177/088307389501000401. PMID: 7594260
Localization in transcortical sensory aphasia.
Kertesz A, Sheppard A, MacKenzie R
Arch Neurol 1982 Aug;39(8):475-8. doi: 10.1001/archneur.1982.00510200017002. PMID: 7103795

Clinical prediction guides

Book talk and aphasia: the power of a book.
Henriksson I, Laakso K
Int J Lang Commun Disord 2020 Jan;55(1):136-148. Epub 2019 Nov 7 doi: 10.1111/1460-6984.12509. PMID: 31697032
Varieties of semantic 'access' deficit in Wernicke's aphasia and semantic aphasia.
Thompson HE, Robson H, Lambon Ralph MA, Jefferies E
Brain 2015 Dec;138(Pt 12):3776-92. Epub 2015 Oct 9 doi: 10.1093/brain/awv281. PMID: 26454668Free PMC Article
Lexical-semantic processing in the semantic priming paradigm in aphasic patients.
Salles JF, Holderbaum CS, Parente MA, Mansur LL, Ansaldo AI
Arq Neuropsiquiatr 2012 Sep;70(9):718-26. doi: 10.1590/s0004-282x2012000900014. PMID: 22990731
Thalamic aphasia syndrome.
Ozeren A, Sarica Y, Efe R
Acta Neurol Belg 1994;94(3):205-8. PMID: 7526590
Intelligence and left hemisphere disease. The role of aphasia, apraxia and size of lesion.
Basso A, Capitani E, Luzzatti C, Spinnler H
Brain 1981 Dec;104(Pt 4):721-34. doi: 10.1093/brain/104.4.721. PMID: 7326564

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