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Benign Ovarian Clear Cell Tumor

MedGen UID:: 307263
•Concept ID:: C1511098
•: Neoplastic Process

Synonym:

Benign Ovarian Clear Cell Neoplasm

Definition

A non-metastasizing neoplasm that arises from the ovary. It is characterized by a predominance of clear and hobnail benign epithelial cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Ovarian Clear Cell Tumor

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign epithelial neoplasm
        Benign Ovarian Epithelial Tumor
        Benign Ovarian Clear Cell Tumor
        Ovarian clear cell adenofibroma
        Ovarian clear cell cystadenofibroma

Professional guidelines

PubMed

Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.

Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971 Free PMC Article

Ber-EP4 and anti-calretinin antibodies: a useful combination for differential diagnosis of various histological types of ovarian cancer cells and mesothelial cells.

Okamoto S, Ito K, Sasano H, Moriya T, Niikura H, Terada Y, Sato S, Okamura K, Yaegashi N
Tohoku J Exp Med 2005 May;206(1):31-40. doi: 10.1620/tjem.206.31. PMID: 15802873

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.

Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

See all (7)

Recent clinical studies

Etiology

Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance.

Steinbuch SC, Lüß AM, Eltrop S, Götte M, Kiesel L
Int J Mol Sci 2024 Apr 13;25(8) doi: 10.3390/ijms25084306. PMID: 38673891 Free PMC Article

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.

Collins KE, Wang X, Klymenko Y, Davis NB, Martinez MC, Zhang C, So K, Buechlein A, Rusch DB, Creighton CJ, Hawkins SM
Front Endocrinol (Lausanne) 2023;14:1162786. Epub 2023 Aug 9 doi: 10.3389/fendo.2023.1162786. PMID: 37621654 Free PMC Article

Cancer Implications for Patients with Endometriosis.

Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216

The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.

Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190 Free PMC Article

The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.

Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587 Free PMC Article

See all (163)

Diagnosis

MR Imaging of Epithelial Ovarian Neoplasms Part II: Malignant.

Xu L, Lee SI, Kilcoyne A
Magn Reson Imaging Clin N Am 2023 Feb;31(1):53-64. doi: 10.1016/j.mric.2022.07.002. PMID: 36368862

A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology.

Sprooten J, Coosemans A, Garg AD
Oncoimmunology 2022;11(1):2024692. Epub 2022 Jan 10 doi: 10.1080/2162402X.2021.2024692. PMID: 35036075 Free PMC Article

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.

Buza N
Arch Pathol Lab Med 2019 Jan;143(1):47-64. doi: 10.5858/arpa.2018-0289-RA. PMID: 30785337

Pathology of borderline and invasive cancers.

Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307

Cancer Implications for Patients with Endometriosis.

Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216

See all (182)

Therapy

The effect of androgens on the risk of endometriosis sub-phenotypes and ovarian neoplasms: A Mendelian randomization study.

Gjorgoska M, Rizner TL
J Steroid Biochem Mol Biol 2024 May;239:106482. Epub 2024 Feb 17 doi: 10.1016/j.jsbmb.2024.106482. PMID: 38369034

Clear cell carcinoma arising in an ovarian remnant 19 years after oophoerctomy: case report.

Yao TT, Zhao SJ, Zhang B
BMC Womens Health 2023 Oct 27;23(1):559. doi: 10.1186/s12905-023-02695-4. PMID: 37891576 Free PMC Article

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.

Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.

Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043

Endometriosis and the development of malignant tumours of the pelvis. A review of literature.

Van Gorp T, Amant F, Neven P, Vergote I, Moerman P
Best Pract Res Clin Obstet Gynaecol 2004 Apr;18(2):349-71. doi: 10.1016/j.bpobgyn.2003.03.001. PMID: 15157647

See all (29)

Prognosis

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.

A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology.

Sprooten J, Coosemans A, Garg AD
Oncoimmunology 2022;11(1):2024692. Epub 2022 Jan 10 doi: 10.1080/2162402X.2021.2024692. PMID: 35036075 Free PMC Article

Pathology of borderline and invasive cancers.

Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307

Ovarian cancer molecular pathology.

Longuespée R, Boyon C, Desmons A, Vinatier D, Leblanc E, Farré I, Wisztorski M, Ly K, D'Anjou F, Day R, Fournier I, Salzet M
Cancer Metastasis Rev 2012 Dec;31(3-4):713-32. doi: 10.1007/s10555-012-9383-7. PMID: 22729278

Teratomas in childhood.

Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

See all (145)

Clinical prediction guides

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.

Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773 Free PMC Article

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.

Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584

Dysregulated expression of long noncoding RNAs in gynecologic cancers.

Hosseini ES, Meryet-Figuiere M, Sabzalipoor H, Kashani HH, Nikzad H, Asemi Z
Mol Cancer 2017 Jun 21;16(1):107. doi: 10.1186/s12943-017-0671-2. PMID: 28637507 Free PMC Article

Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis.

Kobayashi H
Int J Clin Oncol 2009 Oct;14(5):378-82. Epub 2009 Oct 25 doi: 10.1007/s10147-009-0931-2. PMID: 19856043

See all (121)

Recent systematic reviews

Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review.

Butler H, Saulat O, Guinn BA
Carcinogenesis 2022 Apr 25;43(3):183-189. doi: 10.1093/carcin/bgac012. PMID: 35104328 Free PMC Article

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis.

Huo X, Yao L, Han X, Li W, Liu J, Zhou L, Gou Y, Yang K, Liu H
Arch Gynecol Obstet 2019 Mar;299(3):599-607. Epub 2019 Jan 4 doi: 10.1007/s00404-018-5020-1. PMID: 30607584

A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions.

Heatley MK
Int J Gynecol Pathol 2012 Mar;31(2):111-5. doi: 10.1097/PGP.0b013e318226043b. PMID: 22317865

See all (3)

MedGen

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Benign Ovarian Clear Cell Tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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