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Bulky Disease

MedGen UID:
307316
Concept ID:
C1511341
Finding

Definition

Bulk at a site (other than the mediastinum) where any mass measures 10 cm or more by an imaging study. [from NCI]

Professional guidelines

PubMed

Alarcon Tomas A, Fein JA, Fried S, Flynn JR, Devlin SM, Fingrut WB, Anagnostou T, Alperovich A, Shah N, Fraint E, Lin RJ, Scordo M, Batlevi CL, Besser MJ, Dahi PB, Danylesko I, Giralt S, Imber BS, Jacoby E, Kedmi M, Nagler A, Palomba ML, Roshal M, Salles GA, Sauter C, Shem-Tov N, Shimoni A, Yahalom J, Yerushalmi R, Shah GL, Avigdor A, Perales MA, Shouval R
Leukemia 2023 Jan;37(1):154-163. Epub 2022 Nov 5 doi: 10.1038/s41375-022-01739-2. PMID: 36335261Free PMC Article
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Baehring JM, Batchelor TT
Cancer J 2012 Sep-Oct;18(5):463-8. doi: 10.1097/PPO.0b013e31826c5ad5. PMID: 23006953

Recent clinical studies

Etiology

Yamauchi N, Maruyama D
Eur J Haematol 2024 May;112(5):662-677. Epub 2024 Jan 3 doi: 10.1111/ejh.14166. PMID: 38168033
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551
Pfreundschuh M, Kuhnt E, Trümper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, López-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N; MabThera International Trial (MInT) Group
Lancet Oncol 2011 Oct;12(11):1013-22. Epub 2011 Sep 21 doi: 10.1016/S1470-2045(11)70235-2. PMID: 21940214
Kroon BB, Noorda EM, Vrouenraets BC, van Slooten GW, Nieweg OE
Surg Oncol Clin N Am 2008 Oct;17(4):785-94, viii-ix. doi: 10.1016/j.soc.2008.04.005. PMID: 18722918
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

Diagnosis

Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042
DeAngelis LM, Boutros D
Cancer Invest 2005;23(2):145-54. PMID: 15813508
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

Therapy

Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Parrish-Novak J, Holland EC, Olson JM
Cancer J 2015 May-Jun;21(3):206-12. doi: 10.1097/PPO.0000000000000113. PMID: 26049700Free PMC Article
Pfreundschuh M, Kuhnt E, Trümper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, López-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N; MabThera International Trial (MInT) Group
Lancet Oncol 2011 Oct;12(11):1013-22. Epub 2011 Sep 21 doi: 10.1016/S1470-2045(11)70235-2. PMID: 21940214
Rahemtulla A, Terpos E
BMJ Clin Evid 2009 Jun 15;2009 PMID: 21726488Free PMC Article
Kroon BB, Noorda EM, Vrouenraets BC, van Slooten GW, Nieweg OE
Surg Oncol Clin N Am 2008 Oct;17(4):785-94, viii-ix. doi: 10.1016/j.soc.2008.04.005. PMID: 18722918

Prognosis

Tubin S
Semin Radiat Oncol 2024 Jul;34(3):323-336. doi: 10.1016/j.semradonc.2024.04.005. PMID: 38880541
Pfreundschuh M, Trümper L, Osterborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani PL, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, López-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M; MabThera International Trial Group
Lancet Oncol 2006 May;7(5):379-91. doi: 10.1016/S1470-2045(06)70664-7. PMID: 16648042
DeAngelis LM, Boutros D
Cancer Invest 2005;23(2):145-54. PMID: 15813508
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097
Sutton LN, Phillips PC, Molloy PT
J Neurooncol 1996 Jul;29(1):9-21. doi: 10.1007/BF00165514. PMID: 8817412

Clinical prediction guides

Roddie C, Neill L, Osborne W, Iyengar S, Tholouli E, Irvine D, Chaganti S, Besley C, Bloor A, Jones C, Uttenthal B, Johnson R, Sanderson R, Cheok K, Marzolini M, Townsend W, O'Reilly M, Kirkwood AA, Kuhnl A
Blood Adv 2023 Jun 27;7(12):2872-2883. doi: 10.1182/bloodadvances.2022009019. PMID: 36724512Free PMC Article
Alarcon Tomas A, Fein JA, Fried S, Flynn JR, Devlin SM, Fingrut WB, Anagnostou T, Alperovich A, Shah N, Fraint E, Lin RJ, Scordo M, Batlevi CL, Besser MJ, Dahi PB, Danylesko I, Giralt S, Imber BS, Jacoby E, Kedmi M, Nagler A, Palomba ML, Roshal M, Salles GA, Sauter C, Shem-Tov N, Shimoni A, Yahalom J, Yerushalmi R, Shah GL, Avigdor A, Perales MA, Shouval R
Leukemia 2023 Jan;37(1):154-163. Epub 2022 Nov 5 doi: 10.1038/s41375-022-01739-2. PMID: 36335261Free PMC Article
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA
Crit Rev Oncol Hematol 2013 Aug;87(2):146-71. Epub 2013 Jan 30 doi: 10.1016/j.critrevonc.2012.12.009. PMID: 23375551
Rahemtulla A, Terpos E
BMJ Clin Evid 2009 Jun 15;2009 PMID: 21726488Free PMC Article

Recent systematic reviews

Goldkuhle M, Dimaki M, Gartlehner G, Monsef I, Dahm P, Glossmann JP, Engert A, von Tresckow B, Skoetz N
Cochrane Database Syst Rev 2018 Jul 12;7(7):CD012556. doi: 10.1002/14651858.CD012556.pub2. PMID: 30001476Free PMC Article
Morrison J, Haldar K, Kehoe S, Lawrie TA
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005343. doi: 10.1002/14651858.CD005343.pub3. PMID: 22895947Free PMC Article
Rahemtulla A, Terpos E
BMJ Clin Evid 2009 Jun 15;2009 PMID: 21726488Free PMC Article
Rahemtulla A, Terpos E
BMJ Clin Evid 2006 Nov 1;2006 PMID: 19454045
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518

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