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Malignant Lymphoma, Large Cell Type

MedGen UID:: 309381
•Concept ID:: C1518189
•: Neoplastic Process

Definition

An antiquated term that refers to a morphologic variant of non-Hodgkin lymphoma which is composed predominantly or exclusively of large neoplastic lymphocytes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Lymphoma, Large Cell Type

Neoplasm
- Neoplasm by Special Category
  - Neoplasm by Obsolete Classification
    - Hematopoietic and Lymphoid Neoplasm (Antiquated)
      - Lymphoma by Working Formulation (Antiquated)
        Malignant Lymphoma by Cell Type (Working Formulation)
        Malignant Lymphoma, Large Cell Type
        Adult Diffuse Large Cell Lymphoma
        Recurrent Adult Diffuse Large Cell Lymphoma
        Stage I Adult Diffuse Large Cell Lymphoma
        Stage II Adult Diffuse Large Cell Lymphoma
        Stage II Contiguous Adult Diffuse Large Cell Lymphoma
        Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma
        Stage III Adult Diffuse Large Cell Lymphoma
        Stage IV Adult Diffuse Large Cell Lymphoma
        AIDS-Related Diffuse Large Cell Lymphoma
        Childhood Large Cell Lymphoma
        Childhood Diffuse Large Cell Lymphoma
        Recurrent Childhood Large Cell Lymphoma
        Stage I Childhood Large Cell Lymphoma
        Stage II Childhood Large Cell Lymphoma
        Stage III Childhood Large Cell Lymphoma
        Stage IV Childhood Large Cell Lymphoma
        Malignant Lymphoma, Histiocytic, Diffuse
        Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved

Professional guidelines

PubMed

Primary central nervous system lymphoma.

Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012 Free PMC Article

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).

Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107

See all (771)

Recent clinical studies

Etiology

Extranodal T- and NK-cell lymphomas.

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765 Free PMC Article

Classification and diagnostic evaluation of nodal T- and NK-cell lymphomas.

Feldman AL, Laurent C, Narbaitz M, Nakamura S, Chan WC, de Leval L, Gaulard P
Virchows Arch 2023 Jan;482(1):265-279. Epub 2022 Oct 10 doi: 10.1007/s00428-022-03412-6. PMID: 36210383

Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.

Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131

Advances in Diagnosis and Management of Diffuse Large B-cell Lymphoma.

Cabanillas F, Shah B
Clin Lymphoma Myeloma Leuk 2017 Dec;17(12):783-796. Epub 2017 Nov 7 doi: 10.1016/j.clml.2017.10.007. PMID: 29126866

International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes.

Vose J, Armitage J, Weisenburger D; International T-Cell Lymphoma Project
J Clin Oncol 2008 Sep 1;26(25):4124-30. Epub 2008 Jul 14 doi: 10.1200/JCO.2008.16.4558. PMID: 18626005

See all (5298)

Diagnosis

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.

Heming M, Haessner S, Wolbert J, Lu IN, Li X, Brokinkel B, Müther M, Holling M, Stummer W, Thomas C, Schulte-Mecklenbeck A, de Faria F, Stoeckius M, Hailfinger S, Lenz G, Kerl K, Wiendl H, Meyer Zu Hörste G, Grauer OM
Genome Med 2022 Sep 24;14(1):109. doi: 10.1186/s13073-022-01110-1. PMID: 36153593 Free PMC Article

Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment.

van der Horst HJ, de Jonge AV, Hiemstra IH, Gelderloos AT, Berry DRAI, Hijmering NJ, van Essen HF, de Jong D, Chamuleau MED, Zweegman S, Breij ECW, Roemer MGM, Mutis T
Blood Cancer J 2021 Feb 18;11(2):38. doi: 10.1038/s41408-021-00430-6. PMID: 33602901 Free PMC Article

The role of inflammation in lymphoma.

Carbone A, Tripodo C, Carlo-Stella C, Santoro A, Gloghini A
Adv Exp Med Biol 2014;816:315-33. doi: 10.1007/978-3-0348-0837-8_12. PMID: 24818728

Malignant lymphomas.

Tindle BH
Am J Pathol 1984 Jul;116(1):119-74. PMID: 6377907 Free PMC Article

Malignant lymphoma, reticulum cell type. Ultrastructural and cytological demonstration of Lutzner cells.

Petrozzi JW, Raque CJ, Goldschmidt H
Arch Dermatol 1971 Jul;104(1):38-44. PMID: 4941073

See all (8143)

Therapy

Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma.

Corcoran SR, Phelan JD, Choi J, Shevchenko G, Fenner RE, Yu X, Scheich S, Hsiao T, Morris VM, Papachristou EK, Kishore K, D'Santos CS, Ji Y, Pittaluga S, Wright GW, Urlaub H, Pan KT, Oellerich T, Muppidi J, Hodson DJ, Staudt LM
Cancer Discov 2024 Sep 4;14(9):1653-1674. doi: 10.1158/2159-8290.CD-23-0802. PMID: 38683128

Primary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.

Olsen EA, Whittaker S, Willemze R, Pinter-Brown L, Foss F, Geskin L, Schwartz L, Horwitz S, Guitart J, Zic J, Kim YH, Wood GS, Duvic M, Ai W, Girardi M, Gru A, Guenova E, Hodak E, Hoppe R, Kempf W, Kim E, Lechowicz MJ, Ortiz-Romero P, Papadavid E, Quaglino P, Pittelkow M, Prince HM, Sanches JA, Sugaya M, Vermeer M, Zain J, Knobler R, Stadler R, Bagot M, Scarisbrick J
Blood 2022 Aug 4;140(5):419-437. doi: 10.1182/blood.2021012057. PMID: 34758074 Free PMC Article

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Anti-CD19 CAR T-Cell Therapy for B-Cell Non-Hodgkin Lymphoma.

Abramson JS
Transfus Med Rev 2020 Jan;34(1):29-33. Epub 2019 Aug 29 doi: 10.1016/j.tmrv.2019.08.003. PMID: 31677848

Blinatumomab: a historical perspective.

Nagorsen D, Kufer P, Baeuerle PA, Bargou R
Pharmacol Ther 2012 Dec;136(3):334-42. Epub 2012 Aug 24 doi: 10.1016/j.pharmthera.2012.07.013. PMID: 22940266

See all (4757)

Prognosis

Comparison of 2-year outcomes with CAR T cells (ZUMA-1) vs salvage chemotherapy in refractory large B-cell lymphoma.

Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Reagan PM, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Crump M, Kuruvilla J, Van Den Neste E, Farooq U, Navale L, DePuy V, Kim JJ, Gisselbrecht C
Blood Adv 2021 Oct 26;5(20):4149-4155. doi: 10.1182/bloodadvances.2020003848. PMID: 34478487 Free PMC Article

Diffuse large B-cell lymphoma.

Li S, Young KH, Medeiros LJ
Pathology 2018 Jan;50(1):74-87. Epub 2017 Nov 20 doi: 10.1016/j.pathol.2017.09.006. PMID: 29167021

Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin.

Goodlad JR
Surg Pathol Clin 2017 Jun;10(2):429-453. Epub 2017 Mar 18 doi: 10.1016/j.path.2017.01.001. PMID: 28477890

T-cell-rich B-cell lymphoma.

Rodriguez J, Pugh WC, Cabanillas F
Blood 1993 Sep 1;82(5):1586-9. PMID: 8364208

CLUMPING OF WHITE BLOOD CELLS IN MALIGNANT LYMPHOMA AND LEUKEMIA.

HOCHMAN A, ROBINSON E
Oncol 1965;19:71-7. doi: 10.1159/000224286. PMID: 14285016

See all (6396)

Clinical prediction guides

EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2024 update on the diagnosis, risk-stratification, and management.

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2024 Oct;99(10):2002-2015. Epub 2024 Jul 3 doi: 10.1002/ajh.27430. PMID: 38957951

The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice.

Zheng B, Xi Z, Liu R, Yin W, Sui Z, Ren B, Miller H, Gong Q, Liu C
Front Immunol 2018;9:936. Epub 2018 Apr 30 doi: 10.3389/fimmu.2018.00936. PMID: 29760712 Free PMC Article

Neutrophil-rich anaplastic large cell lymphoma expressing interleukin-8.

Miyagawa T, Sugaya M, Okada A, Asano Y, Kadono T, Sato S
Acta Derm Venereol 2014 Nov;94(6):741-2. doi: 10.2340/00015555-1849. PMID: 24676630

Proportions of bone marrow lymphocyte subsets at diagnosis may predict survival in patients with newly diagnosed diffuse large B-cell lymphoma independently of the international prognostic index.

Zurbriggen LD, Gundrum JD, Policepatil SM, Pingali SR, Zeng GG, Go RS
Am J Hematol 2011 Jul;86(7):622-4. doi: 10.1002/ajh.22036. PMID: 21681786

Diffuse aggressive B-cell lymphomas.

Said J
Adv Anat Pathol 2009 Jul;16(4):216-35. doi: 10.1097/PAP.0b013e3181a9d5d2. PMID: 19546610

See all (4942)

Recent systematic reviews

Real-World Outcomes with Chimeric Antigen Receptor T Cell Therapies in Large B Cell Lymphoma: A Systematic Review and Meta-Analysis.

Jacobson CA, Munoz J, Sun F, Kanters S, Limbrick-Oldfield EH, Spooner C, Mignone K, Ayuk F, Sanderson R, Whitmore J, Wang Y, Xu H, Dickinson M
Transplant Cell Ther 2024 Jan;30(1):77.e1-77.e15. Epub 2023 Oct 27 doi: 10.1016/j.jtct.2023.10.017. PMID: 37890589

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.

Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592

Toxicity and efficacy of CAR T-cell therapy in primary and secondary CNS lymphoma: a meta-analysis of 128 patients.

Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735 Free PMC Article

Prognostic Significance of CD30 in Transformed Mycosis Fungoides.

Travaglino A, Russo D, Varricchio S, Pignatiello S, Baldo A, Picardi M, Pane F, Mascolo M
Am J Clin Pathol 2021 Aug 4;156(3):350-355. doi: 10.1093/ajcp/aqaa261. PMID: 33769436

Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.

Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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