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Pulmonary type ovarian small cell carcinoma

MedGen UID:
309517
•Concept ID:
C1518737
•
Neoplastic Process
Synonyms: ovarian small cell carcinoma, pulmonary type; Ovarian Small Cell Carcinoma, Pulmonary-Type; Ovarian Small Cell NEC; Ovarian Small Cell Neuroendocrine Carcinoma; pulmonary type ovarian small cell carcinoma
 
Monarch Initiative: MONDO:0004318

Definition

An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary type ovarian small cell carcinoma

Professional guidelines

PubMed

ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Roskoski R Jr
Pharmacol Res 2017 Jul;121:202-212. Epub 2017 Apr 30 doi: 10.1016/j.phrs.2017.04.022. PMID: 28465216
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Recent clinical studies

Etiology

Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Ling ZN, Hong LL, Wu J, Ling ZQ
Sci Rep 2024 Feb 6;14(1):3030. doi: 10.1038/s41598-024-53489-z. PMID: 38321173Free PMC Article
Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Diagnosis

Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Ling ZN, Hong LL, Wu J, Ling ZQ
Sci Rep 2024 Feb 6;14(1):3030. doi: 10.1038/s41598-024-53489-z. PMID: 38321173Free PMC Article
Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Ovarian pulmonary-type small cell carcinoma diagnosed by means of ascitic fluid cytology: A case report with immunocytochemical analysis.
Ishikawa A, Fujisawa H, Yasumura N, Kuraoka K, Zaitsu J, Saito A, Kan A, Iwahiro K, Kimura F, Nakamura H, Mizunoe T, Taniyama K
Cytopathology 2021 Mar;32(2):250-252. Epub 2020 Nov 20 doi: 10.1111/cyt.12918. PMID: 32989845
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Report of a Bilateral Case in a Teenager Associated with SMARCA4 Germline Mutation.
Lavrut PM, Le Loarer F, Normand C, Grosos C, Dubois R, Buenerd A, Conter C, Dijoud F, Blay JY, Collardeau-Frachon S
Pediatr Dev Pathol 2016 Jan-Feb;19(1):56-60. Epub 2015 Jul 31 doi: 10.2350/15-04-1624-CR.1. PMID: 26230154

Therapy

Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
Primary ovarian small cell carcinoma of pulmonary type with coexisting endometrial carcinoma in a breast cancer patient receiving tamoxifen: A case report and literature review.
Yin L, Li J, Wei Y, Ma D, Sun Y, Sun Y
Medicine (Baltimore) 2018 Jun;97(23):e10900. doi: 10.1097/MD.0000000000010900. PMID: 29879027Free PMC Article
Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
Kurasaki A, Sakurai N, Yamamoto Y, Taoka H, Takahashi K, Kubushiro K
Int J Gynecol Pathol 2013 Sep;32(5):464-70. doi: 10.1097/PGP.0b013e31826d7ea8. PMID: 23896708
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Clinical relevance of non-neuronal auto-antibodies in patients with anti-Hu or anti-Yo paraneoplastic diseases.
Aguirre-Cruz L, Charuel JL, Carpentier AF, Benyahia B, Delattre JY, Musset L
J Neurooncol 2005 Jan;71(1):39-41. doi: 10.1007/s11060-004-4536-3. PMID: 15719273

Prognosis

Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Ling ZN, Hong LL, Wu J, Ling ZQ
Sci Rep 2024 Feb 6;14(1):3030. doi: 10.1038/s41598-024-53489-z. PMID: 38321173Free PMC Article
Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Report of a Bilateral Case in a Teenager Associated with SMARCA4 Germline Mutation.
Lavrut PM, Le Loarer F, Normand C, Grosos C, Dubois R, Buenerd A, Conter C, Dijoud F, Blay JY, Collardeau-Frachon S
Pediatr Dev Pathol 2016 Jan-Feb;19(1):56-60. Epub 2015 Jul 31 doi: 10.2350/15-04-1624-CR.1. PMID: 26230154

Clinical prediction guides

Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Report of a Bilateral Case in a Teenager Associated with SMARCA4 Germline Mutation.
Lavrut PM, Le Loarer F, Normand C, Grosos C, Dubois R, Buenerd A, Conter C, Dijoud F, Blay JY, Collardeau-Frachon S
Pediatr Dev Pathol 2016 Jan-Feb;19(1):56-60. Epub 2015 Jul 31 doi: 10.2350/15-04-1624-CR.1. PMID: 26230154
Effect of ABCG2 genotype on the oral bioavailability of topotecan.
Sparreboom A, Loos WJ, Burger H, Sissung TM, Verweij J, Figg WD, Nooter K, Gelderblom H
Cancer Biol Ther 2005 Jun;4(6):650-8. Epub 2005 Jun 11 doi: 10.4161/cbt.4.6.1731. PMID: 15908806
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

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