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Appendix Tubular Carcinoid

MedGen UID:
310474
•Concept ID:
C1706835
•
Neoplastic Process
Synonym: Appendix Tubular Carcinoid Tumor

Definition

A neuroendocrine tumor that arises from the appendix. It does not show the morphologic characteristics of typical carcinoid tumors (neoplastic cells forming solid nests). In contrast, the tumor cells form small discrete tubules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Tubular Carcinoid

Recent clinical studies

Etiology

Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall.
Matsukuma KE, Montgomery EA
J Clin Pathol 2012 Jul;65(7):666-8. Epub 2012 Mar 29 doi: 10.1136/jclinpath-2011-200639. PMID: 22461652
If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.
Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568
Neuroendocrine tumors of the appendix.
Carr NJ, Sobin LH
Semin Diagn Pathol 2004 May;21(2):108-19. doi: 10.1053/j.semdp.2004.11.004. PMID: 15807471
Dual carcinoid/epithelial neoplasia of the appendix.
Carr NJ, Remotti H, Sobin LH
Histopathology 1995 Dec;27(6):557-62. doi: 10.1111/j.1365-2559.1995.tb00327.x. PMID: 8838336
Goblet cell carcinoids and related tumors of the vermiform appendix.
Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB
Am J Clin Pathol 1990 Jul;94(1):27-35. doi: 10.1093/ajcp/94.1.27. PMID: 2163192

Diagnosis

Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall.
Matsukuma KE, Montgomery EA
J Clin Pathol 2012 Jul;65(7):666-8. Epub 2012 Mar 29 doi: 10.1136/jclinpath-2011-200639. PMID: 22461652
If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.
Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010
Goblet cell carcinoids and related tumors of the vermiform appendix.
Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB
Am J Clin Pathol 1990 Jul;94(1):27-35. doi: 10.1093/ajcp/94.1.27. PMID: 2163192

Therapy

Embryonal rhabdomyosarcoma of the cervix and appendiceal carcinoid tumor.
Adams BN, Brandt JS, Loukeris K, Holcomb K
Obstet Gynecol 2011 Feb;117(2 Pt 2):482-484. doi: 10.1097/AOG.0b013e3182051dd0. PMID: 21252797

Prognosis

Benign non-carcinoid neoplasms of the cecal appendix: presentation of 36 cases during the last 17 years in a third level hospital.
Trujillo-Díaz JJ, Ruiz-Soriano M, de Solórzano-Aurusa JO, De Andrés-Asenjo B, Corrales-Cruz D, Rentería JPBH
Cir Cir 2019;87(6):630-635. doi: 10.24875/CIRU.18000777. PMID: 31631175
If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.
Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568
Neuroendocrine tumors of the appendix.
Carr NJ, Sobin LH
Semin Diagn Pathol 2004 May;21(2):108-19. doi: 10.1053/j.semdp.2004.11.004. PMID: 15807471
Unusual tumors of the appendix and pseudomyxoma peritonei.
Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609
Goblet cell carcinoids and related tumors of the vermiform appendix.
Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB
Am J Clin Pathol 1990 Jul;94(1):27-35. doi: 10.1093/ajcp/94.1.27. PMID: 2163192

Clinical prediction guides

Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients.
Emre A, Akbulut S, Bozdag Z, Yilmaz M, Kanlioz M, Emre R, Sahin N
Int Surg 2013 Oct-Dec;98(4):354-62. doi: 10.9738/INTSURG-D-13-00098.1. PMID: 24229023Free PMC Article
If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies.
Ma KW, Chia NH, Yeung HW, Cheung MT
Hong Kong Med J 2010 Feb;16(1):12-7. PMID: 20124568
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010
Goblet cell carcinoids and related tumors of the vermiform appendix.
Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB
Am J Clin Pathol 1990 Jul;94(1):27-35. doi: 10.1093/ajcp/94.1.27. PMID: 2163192

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