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Oncocytic Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
311067
•Concept ID:
C1709312
•
Neoplastic Process
Synonym: Oxyphilic Variant Thyroid Gland Papillary Carcinoma

Definition

A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of papillary or follicular structures, containing malignant follicular cells with abundant granular eosinophilic cytoplasm. These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOncocytic Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland.
Bankir M, Abayli C, Acibucu F
Arch Endocrinol Metab 2021 Nov 1;64(6):772-778. Epub 2020 Oct 9 doi: 10.20945/2359-3997000000293. PMID: 33049129Free PMC Article

Recent clinical studies

Etiology

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Classification of Thyroid Tumors Based on DNA Methylation Patterns.
Marczyk VR, Recamonde-Mendoza M, Maia AL, Goemann IM
Thyroid 2023 Sep;33(9):1090-1099. Epub 2023 Aug 10 doi: 10.1089/thy.2023.0074. PMID: 37392021
The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841

Diagnosis

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Papillary thyroid carcinoma variants.
Lloyd RV, Buehler D, Khanafshar E
Head Neck Pathol 2011 Mar;5(1):51-6. Epub 2011 Jan 8 doi: 10.1007/s12105-010-0236-9. PMID: 21221869Free PMC Article

Therapy

Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Long-term outcome of rare oncocytic papillary (Hürthle cell) thyroid carcinoma following (adjuvant) initial radioiodine therapy.
Wenter V, Jellinek A, Unterrainer M, Ahmaddy F, Lehner S, Albert NL, Bartenstein P, Knösel T, Spitzweg C, Ilhan H, Todica A
Eur J Nucl Med Mol Imaging 2019 Nov;46(12):2526-2535. Epub 2019 Aug 13 doi: 10.1007/s00259-019-04456-8. PMID: 31410542
Characteristics of young adults of Belarus with post-Chernobyl papillary thyroid carcinoma: a long-term follow-up of patients with early exposure to radiation at the 30th anniversary of the accident.
Fridman M, Lam AK, Krasko O
Clin Endocrinol (Oxf) 2016 Dec;85(6):971-978. Epub 2016 Jul 21 doi: 10.1111/cen.13137. PMID: 27314225
Clinicopathological features of recurrent papillary thyroid cancer.
Zhu J, Wang X, Zhang X, Li P, Hou H
Diagn Pathol 2015 Jul 14;10:96. doi: 10.1186/s13000-015-0346-5. PMID: 26168921Free PMC Article
Can the tall cell variant of papillary thyroid carcinoma be distinguished from the conventional type in fine needle aspirates? A cytomorphologic study with assessment of diagnostic accuracy.
Guan H, Vandenbussche CJ, Erozan YS, Rosenthal DL, Tatsas AD, Olson MT, Zheng R, Auger M, Ali SZ
Acta Cytol 2013;57(5):534-42. Epub 2013 Sep 7 doi: 10.1159/000353823. PMID: 24021475

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Variants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimens.
Canberk S, Montezuma D, Ince U, Tastekin E, Soares P, Bongiovanni M, Schmitt FC
Acta Cytol 2020;64(4):288-298. Epub 2019 Oct 21 doi: 10.1159/000503576. PMID: 31634886
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934

Clinical prediction guides

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
PD-L1 and thyroid cytology: A possible diagnostic and prognostic marker.
Dell'Aquila M, Granitto A, Martini M, Capodimonti S, Cocomazzi A, Musarra T, Fiorentino V, Pontecorvi A, Lombardi CP, Fadda G, Pantanowitz L, Larocca LM, Rossi ED
Cancer Cytopathol 2020 Mar;128(3):177-189. Epub 2019 Dec 10 doi: 10.1002/cncy.22224. PMID: 31821747
Papillary thyroid cancer stroma - histological and immunohistochemical study.
Radu TG, Ciurea ME, Mogoantă SŞ, Busuioc CJ, Grosu F, Ţenovici M, Petrescu IO, Vladu IM
Rom J Morphol Embryol 2016;57(2 Suppl):801-809. PMID: 27833974
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review.
Montone KT, Baloch ZW, LiVolsi VA
Arch Pathol Lab Med 2008 Aug;132(8):1241-50. doi: 10.5858/2008-132-1241-TTHOCA. PMID: 18684023

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