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Radiation Sickness Syndrome

MedGen UID:
311198
Concept ID:
C1709833
Disease or Syndrome

Definition

The complex of symptoms characterizing the disease known as radiation injury, resulting from excessive exposure (greater than 200 rads or 2 gray) of the whole body (or large part) to ionizing radiation. The earliest of these symptoms are nausea, fatigue, vomiting, and diarrhea, which may be followed by epilation, hemorrhage, inflammation of the mouth and throat, and general loss of energy. In severe cases, where the radiation exposure has been approximately 1000 Rad (10 gray) or more, death may occur within two to four weeks. Those who survive six weeks after the receipt of a single large dose of radiation to the whole body may generally be expected to recover. (U.S. Nuclear Regulatory Commission). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation Sickness Syndrome

Professional guidelines

PubMed

Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
Adler Y, Charron P, Imazio M, Badano L, Barón-Esquivias G, Bogaert J, Brucato A, Gueret P, Klingel K, Lionis C, Maisch B, Mayosi B, Pavie A, Ristic AD, Sabaté Tenas M, Seferovic P, Swedberg K, Tomkowski W; ESC Scientific Document Group
Eur Heart J 2015 Nov 7;36(42):2921-2964. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv318. PMID: 26320112Free PMC Article

Recent clinical studies

Etiology

le Polain de Waroux O, Cohuet S, Bishop L, Johnson S, Shaw K, Maguire H, Charlett A, Fraser G
Infect Control Hosp Epidemiol 2011 Oct;32(10):1010-5. Epub 2011 Aug 19 doi: 10.1086/661913. PMID: 21931252
Johnson Liakouris AG
Arch Environ Health 1998 May-Jun;53(3):236-8. doi: 10.1080/00039899809605701. PMID: 9814721

Diagnosis

le Polain de Waroux O, Cohuet S, Bishop L, Johnson S, Shaw K, Maguire H, Charlett A, Fraser G
Infect Control Hosp Epidemiol 2011 Oct;32(10):1010-5. Epub 2011 Aug 19 doi: 10.1086/661913. PMID: 21931252
Johnson Liakouris AG
Arch Environ Health 1998 May-Jun;53(3):236-8. doi: 10.1080/00039899809605701. PMID: 9814721

Therapy

le Polain de Waroux O, Cohuet S, Bishop L, Johnson S, Shaw K, Maguire H, Charlett A, Fraser G
Infect Control Hosp Epidemiol 2011 Oct;32(10):1010-5. Epub 2011 Aug 19 doi: 10.1086/661913. PMID: 21931252

Prognosis

le Polain de Waroux O, Cohuet S, Bishop L, Johnson S, Shaw K, Maguire H, Charlett A, Fraser G
Infect Control Hosp Epidemiol 2011 Oct;32(10):1010-5. Epub 2011 Aug 19 doi: 10.1086/661913. PMID: 21931252

Supplemental Content

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    Practice guidelines

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