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Secondary Glioblastoma

MedGen UID:
311266
•Concept ID:
C1519214
•
Neoplastic Process

Definition

A glioblastoma arising from a lower grade astrocytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Glioblastoma

Professional guidelines

PubMed

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Impact of treatment on survival of patients with secondary glioblastoma.
Hamisch C, Ruge M, Kellermann S, Kohl AC, Duval I, Goldbrunner R, Grau SJ
J Neurooncol 2017 Jun;133(2):309-313. Epub 2017 May 30 doi: 10.1007/s11060-017-2415-y. PMID: 28560660
Thalidomide as palliative treatment in patients with advanced secondary glioblastoma.
Hassler MR, Sax C, Flechl B, Ackerl M, Preusser M, Hainfellner JA, Woehrer A, Dieckmann KU, Rössler K, Prayer D, Marosi C
Oncology 2015;88(3):173-9. doi: 10.1159/000368903. PMID: 25427949

Recent clinical studies

Etiology

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Impact of treatment on survival of patients with secondary glioblastoma.
Hamisch C, Ruge M, Kellermann S, Kohl AC, Duval I, Goldbrunner R, Grau SJ
J Neurooncol 2017 Jun;133(2):309-313. Epub 2017 May 30 doi: 10.1007/s11060-017-2415-y. PMID: 28560660
Glioblastoma.
Wirsching HG, Galanis E, Weller M
Handb Clin Neurol 2016;134:381-97. doi: 10.1016/B978-0-12-802997-8.00023-2. PMID: 26948367
Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?
van Lith SA, Navis AC, Verrijp K, Niclou SP, Bjerkvig R, Wesseling P, Tops B, Molenaar R, van Noorden CJ, Leenders WP
Biochim Biophys Acta 2014 Aug;1846(1):66-74. Epub 2014 Apr 18 doi: 10.1016/j.bbcan.2014.04.004. PMID: 24747768
Advances in the genetics of glioblastoma: are we reaching critical mass?
Purow B, Schiff D
Nat Rev Neurol 2009 Aug;5(8):419-26. Epub 2009 Jul 14 doi: 10.1038/nrneurol.2009.96. PMID: 19597514Free PMC Article

Diagnosis

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution.
Bao Z, Wang Y, Wang Q, Fang S, Shan X, Wang J, Jiang T
Front Med 2021 Aug;15(4):551-561. Epub 2021 Apr 24 doi: 10.1007/s11684-020-0760-2. PMID: 33893983
New Molecular Considerations for Glioma: IDH, ATRX, BRAF, TERT, H3 K27M.
Karsy M, Guan J, Cohen AL, Jensen RL, Colman H
Curr Neurol Neurosci Rep 2017 Feb;17(2):19. doi: 10.1007/s11910-017-0722-5. PMID: 28271343
Glioblastoma.
Wirsching HG, Galanis E, Weller M
Handb Clin Neurol 2016;134:381-97. doi: 10.1016/B978-0-12-802997-8.00023-2. PMID: 26948367
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033
Genetic pathways to primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Am J Pathol 2007 May;170(5):1445-53. doi: 10.2353/ajpath.2007.070011. PMID: 17456751Free PMC Article

Therapy

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development.
Dang L, Su SM
Annu Rev Biochem 2017 Jun 20;86:305-331. Epub 2017 Apr 3 doi: 10.1146/annurev-biochem-061516-044732. PMID: 28375741
Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?
van Lith SA, Navis AC, Verrijp K, Niclou SP, Bjerkvig R, Wesseling P, Tops B, Molenaar R, van Noorden CJ, Leenders WP
Biochim Biophys Acta 2014 Aug;1846(1):66-74. Epub 2014 Apr 18 doi: 10.1016/j.bbcan.2014.04.004. PMID: 24747768
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.
SongTao Q, Lei Y, Si G, YanQing D, HuiXia H, XueLin Z, LanXiao W, Fei Y
Cancer Sci 2012 Feb;103(2):269-73. Epub 2011 Nov 28 doi: 10.1111/j.1349-7006.2011.02134.x. PMID: 22034964

Prognosis

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Targeting gene fusions in glioma.
Kim PL
Curr Opin Neurol 2021 Dec 1;34(6):840-847. doi: 10.1097/WCO.0000000000000991. PMID: 34766555
Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor.
Hu H, Mu Q, Bao Z, Chen Y, Liu Y, Chen J, Wang K, Wang Z, Nam Y, Jiang B, Sa JK, Cho HJ, Her NG, Zhang C, Zhao Z, Zhang Y, Zeng F, Wu F, Kang X, Liu Y, Qian Z, Wang Z, Huang R, Wang Q, Zhang W, Qiu X, Li W, Nam DH, Fan X, Wang J, Jiang T
Cell 2018 Nov 29;175(6):1665-1678.e18. Epub 2018 Oct 18 doi: 10.1016/j.cell.2018.09.038. PMID: 30343896
Glioblastoma.
Wirsching HG, Galanis E, Weller M
Handb Clin Neurol 2016;134:381-97. doi: 10.1016/B978-0-12-802997-8.00023-2. PMID: 26948367
The definition of primary and secondary glioblastoma.
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Clinical prediction guides

Targeting gene fusions in glioma.
Kim PL
Curr Opin Neurol 2021 Dec 1;34(6):840-847. doi: 10.1097/WCO.0000000000000991. PMID: 34766555
Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development.
Dang L, Su SM
Annu Rev Biochem 2017 Jun 20;86:305-331. Epub 2017 Apr 3 doi: 10.1146/annurev-biochem-061516-044732. PMID: 28375741
Glioblastoma.
Wirsching HG, Galanis E, Weller M
Handb Clin Neurol 2016;134:381-97. doi: 10.1016/B978-0-12-802997-8.00023-2. PMID: 26948367
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.
SongTao Q, Lei Y, Si G, YanQing D, HuiXia H, XueLin Z, LanXiao W, Fei Y
Cancer Sci 2012 Feb;103(2):269-73. Epub 2011 Nov 28 doi: 10.1111/j.1349-7006.2011.02134.x. PMID: 22034964
Primary glioblastomas express mesenchymal stem-like properties.
Tso CL, Shintaku P, Chen J, Liu Q, Liu J, Chen Z, Yoshimoto K, Mischel PS, Cloughesy TF, Liau LM, Nelson SF
Mol Cancer Res 2006 Sep;4(9):607-19. doi: 10.1158/1541-7786.MCR-06-0005. PMID: 16966431

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