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Trisomy 3

MedGen UID:
311372
•Concept ID:
C1519652
•
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 3 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 3

Professional guidelines

PubMed

Primary central nervous system marginal zone lymphoma.
Flospergher E, Marino F, Calimeri T, Cangi MG, Ferreri AJM, Ponzoni M, Bongiovanni L
Br J Haematol 2024 Jan;204(1):31-44. Epub 2023 Dec 6 doi: 10.1111/bjh.19238. PMID: 38054330
Prenatal diagnosis of trisomy 21, 18 and 13 by quantitative pyrosequencing of segmental duplications.
Tong H, Jin Y, Xu Y, Zou B, Ye H, Wu H, Kumar S, Pitman JL, Zhou G, Song Q
Clin Genet 2016 Nov;90(5):451-455. Epub 2016 Apr 8 doi: 10.1111/cge.12772. PMID: 26948280
Prenatal diagnosis of trisomy 3 mosaicism.
Zaslav AL, Pierno G, Davis J, Fougner A, Jacob J, Kazi R, Blumenthal D, Sturim S, Shaham M, Fox J
Prenat Diagn 2004 Sep;24(9):693-6. doi: 10.1002/pd.963. PMID: 15386452

Recent clinical studies

Etiology

Primary central nervous system marginal zone lymphoma.
Flospergher E, Marino F, Calimeri T, Cangi MG, Ferreri AJM, Ponzoni M, Bongiovanni L
Br J Haematol 2024 Jan;204(1):31-44. Epub 2023 Dec 6 doi: 10.1111/bjh.19238. PMID: 38054330
Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Influence of Overlapping Genetic Abnormalities on Treatment Outcomes of Multiple Myeloma.
Srour SA, Saliba RM, Bashir Q, Popat UR, Ahmed S, Mehta RS, Delgado R, Rondon G, Parmar S, Kebriaei P, Hosing C, Manasanch EE, Lee HC, Patel KK, Orlowski RZ, Shpall E, Champlin RE, Qazilbash MH, Nieto Y
Transplant Cell Ther 2021 Mar;27(3):243.e1-243.e6. Epub 2020 Dec 20 doi: 10.1016/j.jtct.2020.10.021. PMID: 33781521
Gastric MALT lymphoma: from aetiology to treatment.
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529
Mucosa-associated lymphoid tissue lymphomas.
Gospodarowicz M, Tsang R
Curr Oncol Rep 2000 Mar;2(2):192-8. doi: 10.1007/s11912-000-0093-x. PMID: 11122843

Diagnosis

Primary central nervous system marginal zone lymphoma.
Flospergher E, Marino F, Calimeri T, Cangi MG, Ferreri AJM, Ponzoni M, Bongiovanni L
Br J Haematol 2024 Jan;204(1):31-44. Epub 2023 Dec 6 doi: 10.1111/bjh.19238. PMID: 38054330
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report.
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, Barrie E
Genes Chromosomes Cancer 2022 Aug;61(8):491-496. Epub 2022 Mar 30 doi: 10.1002/gcc.23039. PMID: 35294081Free PMC Article
Prenatal diagnosis of low-level trisomy 3 mosaicism.
Tang W, Wu Y, Liu J, Ren W
Taiwan J Obstet Gynecol 2017 Feb;56(1):114-115. doi: 10.1016/j.tjog.2016.12.008. PMID: 28254212
Trisomy 3 mosaicism in a 5-year-old boy with multiple anomalies: A very rare case.
Yang YJ, Yao X, Guo J, Zhao L, Tu M, Qiou J, Zhao R, Luo Y, Zhu YM
Am J Med Genet A 2016 Jun;170(6):1590-4. Epub 2016 Mar 23 doi: 10.1002/ajmg.a.37618. PMID: 27004455
Prenatal diagnosis of trisomy 3 mosaicism.
Zaslav AL, Pierno G, Davis J, Fougner A, Jacob J, Kazi R, Blumenthal D, Sturim S, Shaham M, Fox J
Prenat Diagn 2004 Sep;24(9):693-6. doi: 10.1002/pd.963. PMID: 15386452

Therapy

Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy.
Taji S, Nomura K, Matsumoto Y, Sakabe H, Yoshida N, Mitsufuji S, Nishida K, Horiike S, Nakamura S, Morita M, Taniwaki M
World J Gastroenterol 2005 Jan 7;11(1):89-93. doi: 10.3748/wjg.v11.i1.89. PMID: 15609403Free PMC Article
Mucosa-associated lymphoid tissue lymphomas.
Gospodarowicz M, Tsang R
Curr Oncol Rep 2000 Mar;2(2):192-8. doi: 10.1007/s11912-000-0093-x. PMID: 11122843
Distinct chromosome 3 abnormalities in persistent polyclonal B-cell lymphocytosis.
Callet-Bauchu E, Gazzo S, Poncet C, Pagès J, Morel D, Alliot C, Coiffier B, Coeur P, Salles G, Felman P
Genes Chromosomes Cancer 1999 Nov;26(3):221-8. doi: 10.1002/(sici)1098-2264(199911)26:3<221::aid-gcc6>3.0.co;2-9. PMID: 10502320
Chromosome aberrations in metastatic ovarian cancer: relationship with abnormalities in primary tumors.
Bello MJ, Rey JA
Int J Cancer 1990 Jan 15;45(1):50-4. doi: 10.1002/ijc.2910450111. PMID: 2298505

Prognosis

Primary central nervous system marginal zone lymphoma.
Flospergher E, Marino F, Calimeri T, Cangi MG, Ferreri AJM, Ponzoni M, Bongiovanni L
Br J Haematol 2024 Jan;204(1):31-44. Epub 2023 Dec 6 doi: 10.1111/bjh.19238. PMID: 38054330
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report.
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, Barrie E
Genes Chromosomes Cancer 2022 Aug;61(8):491-496. Epub 2022 Mar 30 doi: 10.1002/gcc.23039. PMID: 35294081Free PMC Article
Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Gastric MALT lymphoma: from aetiology to treatment.
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529
Mucosa-associated lymphoid tissue lymphomas.
Gospodarowicz M, Tsang R
Curr Oncol Rep 2000 Mar;2(2):192-8. doi: 10.1007/s11912-000-0093-x. PMID: 11122843

Clinical prediction guides

Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report.
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, Barrie E
Genes Chromosomes Cancer 2022 Aug;61(8):491-496. Epub 2022 Mar 30 doi: 10.1002/gcc.23039. PMID: 35294081Free PMC Article
Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: A retrospective single-center analysis of 72 cases.
Zhang C, Xia R, Gu T, Wang L, Tian Z, Zhu L, Han J, Hu Y, Wang Y, Sun J, Li J
J Oral Pathol Med 2021 Aug;50(7):723-730. Epub 2021 Mar 29 doi: 10.1111/jop.13168. PMID: 33730431
Mucosa-associated lymphoid tissue lymphomas.
Gospodarowicz M, Tsang R
Curr Oncol Rep 2000 Mar;2(2):192-8. doi: 10.1007/s11912-000-0093-x. PMID: 11122843
Cytogenetics of non-Hodgkin's lymphoma.
Levine EG, Bloomfield CD
J Natl Cancer Inst Monogr 1990;(10):7-12. PMID: 2189479

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