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Vaginal Undifferentiated Carcinoma

MedGen UID:
311448
Concept ID:
C1519934
Neoplastic Process

Definition

A carcinoma that arises from the vagina and is characterized by the lack of specific cellular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Undifferentiated Carcinoma

Professional guidelines

PubMed

Jhingran A
Int J Gynecol Cancer 2022 Mar;32(3):344-351. doi: 10.1136/ijgc-2021-002517. PMID: 35256422Free PMC Article
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Wortman BG, Creutzberg CL, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LCHW, van der Steen-Banasik EM, Mens JWM, Slot A, Kroese MCS, van Triest B, Nijman HW, Stelloo E, Bosse T, de Boer SM, van Putten WLJ, Smit VTHBM, Nout RA; PORTEC Study Group
Br J Cancer 2018 Oct;119(9):1067-1074. Epub 2018 Oct 25 doi: 10.1038/s41416-018-0310-8. PMID: 30356126Free PMC Article
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Klein JR
Pediatr Clin North Am 1980 Feb;27(1):141-52. doi: 10.1016/s0031-3955(16)33825-1. PMID: 6990360
Keirse MJ
Postgrad Med J 1973 May;49(571):344-8. doi: 10.1136/pgmj.49.571.344. PMID: 4804457Free PMC Article

Diagnosis

Wei KX, Hoang LN
Surg Pathol Clin 2022 Jun;15(2):389-405. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.011. PMID: 35715167
Jhingran A
Int J Gynecol Cancer 2022 Mar;32(3):344-351. doi: 10.1136/ijgc-2021-002517. PMID: 35256422Free PMC Article
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Othman NH, Ismail AN
Eur J Obstet Gynecol Reprod Biol 1993 Dec 15;52(2):135-7. doi: 10.1016/0028-2243(93)90240-d. PMID: 8157142

Therapy

van den Heerik ASVM, Horeweg N, Nout RA, Lutgens LCHW, van der Steen-Banasik EM, Westerveld GH, van den Berg HA, Slot A, Koppe FLA, Kommoss S, Mens JWM, Nowee ME, Bijmolt S, Cibula D, Stam TC, Jurgenliemk-Schulz IM, Snyers A, Hamann M, Zwanenburg AG, Coen VLMA, Vandecasteele K, Gillham C, Chargari C, Verhoeven-Adema KW, Putter H, van den Hout WB, Wortman BG, Nijman HW, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2020 Dec;30(12):2002-2007. Epub 2020 Oct 12 doi: 10.1136/ijgc-2020-001929. PMID: 33046573Free PMC Article
Randall ME, Filiaci V, McMeekin DS, von Gruenigen V, Huang H, Yashar CM, Mannel RS, Kim JW, Salani R, DiSilvestro PA, Burke JJ, Rutherford T, Spirtos NM, Terada K, Anderson PR, Brewster WR, Small W, Aghajanian CA, Miller DS
J Clin Oncol 2019 Jul 20;37(21):1810-1818. Epub 2019 Apr 17 doi: 10.1200/JCO.18.01575. PMID: 30995174Free PMC Article
Wortman BG, Creutzberg CL, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LCHW, van der Steen-Banasik EM, Mens JWM, Slot A, Kroese MCS, van Triest B, Nijman HW, Stelloo E, Bosse T, de Boer SM, van Putten WLJ, Smit VTHBM, Nout RA; PORTEC Study Group
Br J Cancer 2018 Oct;119(9):1067-1074. Epub 2018 Oct 25 doi: 10.1038/s41416-018-0310-8. PMID: 30356126Free PMC Article
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Klein JR
Pediatr Clin North Am 1980 Feb;27(1):141-52. doi: 10.1016/s0031-3955(16)33825-1. PMID: 6990360

Prognosis

Arakawa A, Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, Hirabayashi S, Hasegawa D, Manabe A, Ono K, Matsuoka M, Arai Y, Togashi Y, Shibata T, Nishikawa H, Aoki K, Yamamoto N, Kohno T, Ogawa C
N Engl J Med 2021 Jan 7;384(1):42-50. doi: 10.1056/NEJMoa2030391. PMID: 33406329
Benhayoune K, El Fatemi H, El Ghaouti M, Bannani A, Melhouf A, Harmouch T
Pan Afr Med J 2015;20:124. Epub 2015 Feb 12 doi: 10.11604/pamj.2015.20.124.5927. PMID: 26097628Free PMC Article
Gadducci A, Fabrini MG, Lanfredini N, Sergiampietri C
Crit Rev Oncol Hematol 2015 Mar;93(3):211-24. Epub 2014 Oct 5 doi: 10.1016/j.critrevonc.2014.09.002. PMID: 25476235
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777
Creasman WT
Curr Opin Obstet Gynecol 2005 Feb;17(1):71-6. doi: 10.1097/00001703-200502000-00013. PMID: 15711415

Clinical prediction guides

Lorentzen GM, Łaniewski P, Cui H, Mahnert ND, Mourad J, Borst MP, Willmott L, Chase DM, Roe DJ, Herbst-Kralovetz MM
Clin Cancer Res 2024 Jul 15;30(14):3073-3087. doi: 10.1158/1078-0432.CCR-23-2934. PMID: 38687603Free PMC Article
Salem H, El-Mazny A
J Obstet Gynaecol 2012 Aug;32(6):590-3. doi: 10.3109/01443615.2012.693980. PMID: 22779969
Baltzer J, Zander J
Gynecol Oncol 1989 Oct;35(1):99-103. doi: 10.1016/0090-8258(89)90021-8. PMID: 2676753
Welch WR, Robboy SJ, Kaufman RH, Townsend D, Noller KL, Gundersen J, Lawrence WD, Richart RM, O'Brien P, McGorray S
Gynecol Oncol 1985 Jul;21(3):277-86. doi: 10.1016/0090-8258(85)90264-1. PMID: 4007608
Gupta S, Gupta YN, Sanyal B
J Surg Oncol 1982 Feb;19(2):71-3. doi: 10.1002/jso.2930190204. PMID: 7057651

Recent systematic reviews

Frigerio M, Inzoli A, Barba M
Int J Gynaecol Obstet 2022 Nov;159(2):365-371. Epub 2022 Feb 28 doi: 10.1002/ijgo.14137. PMID: 35167139
Inayama Y, Yamanishi Y, Nakatani E, Aratake J, Sasagasako N, Yamada K, Gou R, Kawamura A, Yamanishi M, Kosaka K
Gynecol Oncol 2021 Jan;160(1):140-147. Epub 2020 Oct 1 doi: 10.1016/j.ygyno.2020.09.031. PMID: 33010966
Frias-Gomez J, Benavente Y, Ponce J, Brunet J, Ibáñez R, Peremiquel-Trillas P, Baixeras N, Zanca A, Piulats JM, Aytés Á, Matias-Guiu X, Bosch FX, de Sanjosé S, Alemany L, Costas L; Screenwide Team
Cancer Cytopathol 2020 Nov;128(11):792-802. Epub 2020 Mar 23 doi: 10.1002/cncy.22266. PMID: 32202704
Guerri S, Perrone AM, Buwenge M, Ferioli M, Macchia G, Tagliaferri L, Ferrandina G, Galuppi A, Andrulli AD, Frakulli R, Cammelli S, Arcelli A, De Iaco P, Morganti AG
Oncologist 2019 Jan;24(1):132-141. Epub 2018 Aug 23 doi: 10.1634/theoncologist.2017-0546. PMID: 30139838Free PMC Article
Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H
Clin Infect Dis 2006 Jul 15;43(2):223-33. Epub 2006 Jun 7 doi: 10.1086/505219. PMID: 16779751

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