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Osteoblastic osteosarcoma

MedGen UID:
312376
•Concept ID:
C1704328
•
Neoplastic Process
Synonyms: Osteoblastic Osteosarcoma; osteoblastic osteosarcoma
 
Monarch Initiative: MONDO:0020660

Definition

A conventional osteosarcoma characterized by the predominance of osteoid matrix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Osteoblastic osteosarcoma

Professional guidelines

PubMed

KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics.
Jiang L, Liu J, Wei Q, Wang Y
Diagn Pathol 2020 Nov 11;15(1):135. doi: 10.1186/s13000-020-01051-6. PMID: 33176814Free PMC Article
Novel oncologic, surgical, and prosthetic treatment of high-grade surface osteosarcoma, osteoblastic mandible type.
Dhima M, Arce K, Moore EJ, Rieck KL, Salinas TJ
J Oral Maxillofac Surg 2013 May;71(5):e224-31. Epub 2013 Jan 5 doi: 10.1016/j.joms.2012.11.003. PMID: 23298800
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

Recent clinical studies

Etiology

Tumor necrosis drives prognosis in osteosarcoma: No difference in chemotherapy response and survival between chondroblastic and osteoblastic osteosarcoma.
Patel N, Werenski JO, Gonzalez MR, Clunk MJ, McCadden MR, Richard A, Chebib I, Hung YP, Nielsen GP, Lozano-Calderon SA
Surg Oncol 2024 Dec;57:102155. Epub 2024 Oct 11 doi: 10.1016/j.suronc.2024.102155. PMID: 39423470
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Zhang Z, Ji W, Huang J, Zhang Y, Zhou Y, Zhang J, Dong Y, Yuan T, Yang Q, Ding X, Tang L, Li H, Yin J, Wang Y, Ji T, Fei J, Zhang B, Chen P, Hu H
Clin Transl Med 2022 Nov;12(11):e1072. doi: 10.1002/ctm2.1072. PMID: 36305631Free PMC Article
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
Pugi A, Benemei S, Vietri M, Tondo A, Calvani AM, Mugelli A, Vannacci A, Lapi F
J Clin Pharm Ther 2012 Apr;37(2):245-8. Epub 2011 May 13 doi: 10.1111/j.1365-2710.2011.01275.x. PMID: 21569069
Reduced methotrexate clearance and renal impairment in a boy with osteosarcoma and earlier undetected autosomal dominant polycystic kidney disease (ADPKD).
Alberer M, Hoefele J, Bergmann C, Hartrampf S, Hilberath J, Pawlita I, Albert MH, Benz MR, Weber LT, Schmid I
J Pediatr Hematol Oncol 2010 Nov;32(8):e314-6. doi: 10.1097/MPH.0b013e3181e92af4. PMID: 20921908

Diagnosis

A Rare Location of Osteosarcoma in the Cuboid Bone: A Case Report.
Dhillon N, Vijayakumar G, Tepper SC, Braun A, Blank AT
JBJS Case Connect 2023 Jul 1;13(3) Epub 2023 Aug 3 doi: 10.2106/JBJS.CC.22.00690. PMID: 37535761
Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literature review.
Qiu YQ, Chen YL
Osteoporos Int 2021 May;32(5):1007-1012. Epub 2020 Oct 12 doi: 10.1007/s00198-020-05675-8. PMID: 33047193
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887
Osteoblastic osteosarcoma in monostotic Paget's disease.
Calabrò T, Mavrogenis AF, Ruggieri P
Musculoskelet Surg 2011 Apr;95(1):37-40. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0100-4. PMID: 21409504
Gliosarcoma with features of osteoblastic osteosarcoma: a review.
Barresi V, Cerasoli S, Morigi F, Cremonini AM, Volpini M, Tuccari G
Arch Pathol Lab Med 2006 Aug;130(8):1208-11. doi: 10.5858/2006-130-1208-GWFOOO. PMID: 16879025

Therapy

Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-EDTMP and radium-223.
Anderson PM, Subbiah V, Rohren E
Adv Exp Med Biol 2014;804:291-304. doi: 10.1007/978-3-319-04843-7_16. PMID: 24924181
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
Pugi A, Benemei S, Vietri M, Tondo A, Calvani AM, Mugelli A, Vannacci A, Lapi F
J Clin Pharm Ther 2012 Apr;37(2):245-8. Epub 2011 May 13 doi: 10.1111/j.1365-2710.2011.01275.x. PMID: 21569069
Osteoblastic osteosarcoma in monostotic Paget's disease.
Calabrò T, Mavrogenis AF, Ruggieri P
Musculoskelet Surg 2011 Apr;95(1):37-40. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0100-4. PMID: 21409504
Red clover extracts stimulate differentiation of human osteoblastic osteosarcoma HOS58 cells.
Wende K, Krenn L, Unterrieder I, Lindequist U
Planta Med 2004 Oct;70(10):1003-5. doi: 10.1055/s-2004-832629. PMID: 15490331
Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells.
Zhang W, Dziak R
Prostaglandins Leukot Essent Fatty Acids 1996 Jun;54(6):427-31. doi: 10.1016/s0952-3278(96)90026-5. PMID: 8888354

Prognosis

A Rare Location of Osteosarcoma in the Cuboid Bone: A Case Report.
Dhillon N, Vijayakumar G, Tepper SC, Braun A, Blank AT
JBJS Case Connect 2023 Jul 1;13(3) Epub 2023 Aug 3 doi: 10.2106/JBJS.CC.22.00690. PMID: 37535761
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Zhang Z, Ji W, Huang J, Zhang Y, Zhou Y, Zhang J, Dong Y, Yuan T, Yang Q, Ding X, Tang L, Li H, Yin J, Wang Y, Ji T, Fei J, Zhang B, Chen P, Hu H
Clin Transl Med 2022 Nov;12(11):e1072. doi: 10.1002/ctm2.1072. PMID: 36305631Free PMC Article
Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literature review.
Qiu YQ, Chen YL
Osteoporos Int 2021 May;32(5):1007-1012. Epub 2020 Oct 12 doi: 10.1007/s00198-020-05675-8. PMID: 33047193
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
Pugi A, Benemei S, Vietri M, Tondo A, Calvani AM, Mugelli A, Vannacci A, Lapi F
J Clin Pharm Ther 2012 Apr;37(2):245-8. Epub 2011 May 13 doi: 10.1111/j.1365-2710.2011.01275.x. PMID: 21569069

Clinical prediction guides

Tumor necrosis drives prognosis in osteosarcoma: No difference in chemotherapy response and survival between chondroblastic and osteoblastic osteosarcoma.
Patel N, Werenski JO, Gonzalez MR, Clunk MJ, McCadden MR, Richard A, Chebib I, Hung YP, Nielsen GP, Lozano-Calderon SA
Surg Oncol 2024 Dec;57:102155. Epub 2024 Oct 11 doi: 10.1016/j.suronc.2024.102155. PMID: 39423470
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
Intraoral Anastomosis of Deep Circumflex Iliac Artery Perforator Flap for Maxillary Reconstruction.
Wu WJ, Lv XM, Zhang JG, Zheng L
J Craniofac Surg 2018 Oct;29(7):e695-e697. doi: 10.1097/SCS.0000000000004941. PMID: 30192289
Bone environment is essential for osteosarcoma development from transformed mesenchymal stem cells.
Rubio R, Abarrategi A, Garcia-Castro J, Martinez-Cruzado L, Suarez C, Tornin J, Santos L, Astudillo A, Colmenero I, Mulero F, Rosu-Myles M, Menendez P, Rodriguez R
Stem Cells 2014 May;32(5):1136-48. doi: 10.1002/stem.1647. PMID: 24446210
Osteoblastic osteosarcoma in monostotic Paget's disease.
Calabrò T, Mavrogenis AF, Ruggieri P
Musculoskelet Surg 2011 Apr;95(1):37-40. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0100-4. PMID: 21409504

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

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