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Advanced Adult Hepatocellular Carcinoma

MedGen UID:
312876
Concept ID:
C1706732
Neoplastic Process
Synonym: Advanced Adult Hepatoma

Definition

A hepatocellular carcinoma that occurs during adulthood and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adult Hepatocellular Carcinoma

Professional guidelines

PubMed

European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J
J Hepatol 2022 Mar;76(3):681-693. Epub 2021 Nov 19 doi: 10.1016/j.jhep.2021.11.018. PMID: 34801630Free PMC Article
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article

Recent clinical studies

Etiology

Du J, Huang Z
Sci Rep 2024 Aug 23;14(1):19583. doi: 10.1038/s41598-024-68048-9. PMID: 39179639Free PMC Article
Kim A, Park G, Goh MJ, Song BG, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Sinn DH
Sci Rep 2024 Jul 4;14(1):15418. doi: 10.1038/s41598-024-66253-0. PMID: 38965335Free PMC Article
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article
Yoon SM, Ryoo BY, Lee SJ, Kim JH, Shin JH, An JH, Lee HC, Lim YS
JAMA Oncol 2018 May 1;4(5):661-669. doi: 10.1001/jamaoncol.2017.5847. PMID: 29543938Free PMC Article
Wang Y, Huo X, Cao Z, Xu H, Zhu J, Qian L, Fu H, Xu B
Int J Clin Exp Pathol 2015;8(7):8099-106. Epub 2015 Jul 1 PMID: 26339377Free PMC Article

Diagnosis

Ding J, Wen Z
BMC Cancer 2021 Oct 29;21(1):1157. doi: 10.1186/s12885-021-08904-3. PMID: 34715816Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Qin S, Ren Z, Meng Z, Chen Z, Chai X, Xiong J, Bai Y, Yang L, Zhu H, Fang W, Lin X, Chen X, Li E, Wang L, Chen C, Zou J
Lancet Oncol 2020 Apr;21(4):571-580. Epub 2020 Feb 26 doi: 10.1016/S1470-2045(20)30011-5. PMID: 32112738
Calandri M, Mauri G, Yevich S, Gazzera C, Basile D, Gatti M, Veltri A, Fonio P
Cardiovasc Intervent Radiol 2019 May;42(5):639-647. Epub 2019 Feb 26 doi: 10.1007/s00270-019-02167-z. PMID: 30809699
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article

Therapy

Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Sonbol MB, Riaz IB, Naqvi SAA, Almquist DR, Mina S, Almasri J, Shah S, Almader-Douglas D, Uson Junior PLS, Mahipal A, Ma WW, Jin Z, Mody K, Starr J, Borad MJ, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Dec 1;6(12):e204930. Epub 2020 Dec 10 doi: 10.1001/jamaoncol.2020.4930. PMID: 33090186Free PMC Article
Qin S, Ren Z, Meng Z, Chen Z, Chai X, Xiong J, Bai Y, Yang L, Zhu H, Fang W, Lin X, Chen X, Li E, Wang L, Chen C, Zou J
Lancet Oncol 2020 Apr;21(4):571-580. Epub 2020 Feb 26 doi: 10.1016/S1470-2045(20)30011-5. PMID: 32112738
Duffy AG, Ulahannan SV, Makorova-Rusher O, Rahma O, Wedemeyer H, Pratt D, Davis JL, Hughes MS, Heller T, ElGindi M, Uppala A, Korangy F, Kleiner DE, Figg WD, Venzon D, Steinberg SM, Venkatesan AM, Krishnasamy V, Abi-Jaoudeh N, Levy E, Wood BJ, Greten TF
J Hepatol 2017 Mar;66(3):545-551. Epub 2016 Nov 2 doi: 10.1016/j.jhep.2016.10.029. PMID: 27816492Free PMC Article

Prognosis

Kim A, Park G, Goh MJ, Song BG, Kang W, Gwak GY, Paik YH, Choi MS, Lee JH, Sinn DH
Sci Rep 2024 Jul 4;14(1):15418. doi: 10.1038/s41598-024-66253-0. PMID: 38965335Free PMC Article
Mao J, Wang D, Long J, Yang X, Lin J, Song Y, Xie F, Xun Z, Wang Y, Wang Y, Li Y, Sun H, Xue J, Song Y, Zuo B, Zhang J, Bian J, Zhang T, Yang X, Zhang L, Sang X, Zhao H
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003334. PMID: 34873013Free PMC Article
Ding J, Wen Z
BMC Cancer 2021 Oct 29;21(1):1157. doi: 10.1186/s12885-021-08904-3. PMID: 34715816Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Vilar-Gomez E, Calzadilla-Bertot L, Wai-Sun Wong V, Castellanos M, Aller-de la Fuente R, Metwally M, Eslam M, Gonzalez-Fabian L, Alvarez-Quiñones Sanz M, Conde-Martin AF, De Boer B, McLeod D, Hung Chan AW, Chalasani N, George J, Adams LA, Romero-Gomez M
Gastroenterology 2018 Aug;155(2):443-457.e17. Epub 2018 May 5 doi: 10.1053/j.gastro.2018.04.034. PMID: 29733831

Clinical prediction guides

Du J, Huang Z
Sci Rep 2024 Aug 23;14(1):19583. doi: 10.1038/s41598-024-68048-9. PMID: 39179639Free PMC Article
Vibert E, Schwartz M, Olthoff KM
J Hepatol 2020 Feb;72(2):262-276. doi: 10.1016/j.jhep.2019.11.017. PMID: 31954491
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254. Epub 2018 Dec 13 doi: 10.1016/j.ebiom.2018.11.063. PMID: 30555042Free PMC Article
Pinyol R, Montal R, Bassaganyas L, Sia D, Takayama T, Chau GY, Mazzaferro V, Roayaie S, Lee HC, Kokudo N, Zhang Z, Torrecilla S, Moeini A, Rodriguez-Carunchio L, Gane E, Verslype C, Croitoru AE, Cillo U, de la Mata M, Lupo L, Strasser S, Park JW, Camps J, Solé M, Thung SN, Villanueva A, Pena C, Meinhardt G, Bruix J, Llovet JM
Gut 2019 Jun;68(6):1065-1075. Epub 2018 Aug 14 doi: 10.1136/gutjnl-2018-316408. PMID: 30108162Free PMC Article
Yoon SM, Ryoo BY, Lee SJ, Kim JH, Shin JH, An JH, Lee HC, Lim YS
JAMA Oncol 2018 May 1;4(5):661-669. doi: 10.1001/jamaoncol.2017.5847. PMID: 29543938Free PMC Article

Recent systematic reviews

Gryziak M, Woźniak K, Kraj L, Stec R
Crit Rev Oncol Hematol 2021 Jan;157:103179. Epub 2020 Nov 18 doi: 10.1016/j.critrevonc.2020.103179. PMID: 33302158
Sonbol MB, Riaz IB, Naqvi SAA, Almquist DR, Mina S, Almasri J, Shah S, Almader-Douglas D, Uson Junior PLS, Mahipal A, Ma WW, Jin Z, Mody K, Starr J, Borad MJ, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Dec 1;6(12):e204930. Epub 2020 Dec 10 doi: 10.1001/jamaoncol.2020.4930. PMID: 33090186Free PMC Article
Jarvis H, Craig D, Barker R, Spiers G, Stow D, Anstee QM, Hanratty B
PLoS Med 2020 Apr;17(4):e1003100. Epub 2020 Apr 30 doi: 10.1371/journal.pmed.1003100. PMID: 32353039Free PMC Article
Peng JK, Hepgul N, Higginson IJ, Gao W
Palliat Med 2019 Jan;33(1):24-36. Epub 2018 Oct 22 doi: 10.1177/0269216318807051. PMID: 30345878Free PMC Article
Vernon G, Baranova A, Younossi ZM
Aliment Pharmacol Ther 2011 Aug;34(3):274-85. Epub 2011 May 30 doi: 10.1111/j.1365-2036.2011.04724.x. PMID: 21623852

Supplemental Content

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    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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