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Colon signet ring cell adenocarcinoma

MedGen UID:
313039
•Concept ID:
C1707436
•
Neoplastic Process
Synonyms: colon signet ring adenocarcinoma; Colon Signet Ring Cell Adenocarcinoma; colon signet ring cell adenocarcinoma; colon signet Ring cell adenocarcinoma; Colon Signet-Ring Cell Adenocarcinoma; colonic signet Ring adenocarcinoma; Colonic Signet Ring Cell Adenocarcinoma; colonic signet Ring cell adenocarcinoma; Signet Ring Cell Adenocarcinoma of Colon; signet Ring cell adenocarcinoma of colon; Signet Ring Cell Adenocarcinoma of the Colon; signet Ring cell adenocarcinoma of the colon; Signet Ring Cell Colon Adenocarcinoma; signet Ring cell colon adenocarcinoma
 
Monarch Initiative: MONDO:0002495

Definition

An invasive adenocarcinoma of the colon characterized by the presence of malignant glandular epithelial cells which contain prominent intracytoplasmic mucin (signet ring cells). The signet ring cells constitute more than 50% of the malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon signet ring cell adenocarcinoma

Professional guidelines

PubMed

Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes.
Franko J, Le VH, Tee MC, Lin M, Sedinkin J, Raman S, Frankova D
Cancer Treat Res Commun 2021;29:100475. Epub 2021 Oct 11 doi: 10.1016/j.ctarc.2021.100475. PMID: 34655861
Signet ring cell carcinoma in urine cytology: cytomorphologic findings and differential diagnosis.
Guan H, Tatsas AD, Ali SZ
Acta Cytol 2012;56(2):177-82. Epub 2012 Feb 17 doi: 10.1159/000335118. PMID: 22378081

Recent clinical studies

Etiology

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Metastatic signet ring colon cancer in a Caribbean young adult and review of the literature.
Koczka CP, Goodman A
Eur J Gastroenterol Hepatol 2012 Jun;24(6):731-4. doi: 10.1097/MEG.0b013e328352819d. PMID: 22422005
Metastatic factors for Krukenberg tumor: a clinical study on 102 cases.
Qiu L, Yang T, Shan XH, Hu MB, Li Y
Med Oncol 2011 Dec;28(4):1514-9. Epub 2010 Jul 7 doi: 10.1007/s12032-010-9610-4. PMID: 20607456

Diagnosis

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Undiagnosed Case of Signet Ring Cell Colorectal Carcinoma: A Case Report and Review of the Literature.
Henry M, Delavari N, Webber J
Clin Colorectal Cancer 2020 Sep;19(3):e83-e86. Epub 2020 May 8 doi: 10.1016/j.clcc.2020.04.005. PMID: 32586730
Esophageal Pneumatosis and Signet Ring Cell Colon Carcinoma.
Shojamanesh H, Melgoza F, Pan D
Am J Gastroenterol 2019 Sep;114(9):1415. doi: 10.14309/ajg.0000000000000263. PMID: 31082872
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Therapy

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Undiagnosed Case of Signet Ring Cell Colorectal Carcinoma: A Case Report and Review of the Literature.
Henry M, Delavari N, Webber J
Clin Colorectal Cancer 2020 Sep;19(3):e83-e86. Epub 2020 May 8 doi: 10.1016/j.clcc.2020.04.005. PMID: 32586730
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Irinotecan use during pregnancy.
Taylor J, Amanze A, Di Federico E, Verschraegen C
Obstet Gynecol 2009 Aug;114(2 Pt 2):451-452. doi: 10.1097/AOG.0b013e3181a1d478. PMID: 19622957

Prognosis

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Primary signet ring cell carcinoma of the colon and rectum.
Arifi S, Elmesbahi O, Amarti Riffi A
Bull Cancer 2015 Oct;102(10):880-8. Epub 2015 Sep 26 doi: 10.1016/j.bulcan.2015.07.005. PMID: 26412710
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article

Clinical prediction guides

Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682
Ulcerative colitis-associated colorectal cancer.
Yashiro M
World J Gastroenterol 2014 Nov 28;20(44):16389-97. doi: 10.3748/wjg.v20.i44.16389. PMID: 25469007Free PMC Article
Metastatic factors for Krukenberg tumor: a clinical study on 102 cases.
Qiu L, Yang T, Shan XH, Hu MB, Li Y
Med Oncol 2011 Dec;28(4):1514-9. Epub 2010 Jul 7 doi: 10.1007/s12032-010-9610-4. PMID: 20607456

Recent systematic reviews

Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review.
Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A
JAMA Netw Open 2022 May 2;5(5):e2213588. doi: 10.1001/jamanetworkopen.2022.13588. PMID: 35608860Free PMC Article
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature.
Kodama M, Moeini A, Machida H, Blake EA, Grubbs BH, Matsuo K
Arch Gynecol Obstet 2016 Sep;294(3):589-98. Epub 2016 Feb 20 doi: 10.1007/s00404-016-4048-3. PMID: 26897498
Fifty-three years of reporting colorectal cancer in Nigerians--a systematic review of the published literature.
Rotimi O, Abdulkareem FB
Niger Postgrad Med J 2014 Mar;21(1):68-73. PMID: 24956622

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