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HIV Lipodystrophy

MedGen UID:: 313244
•Concept ID:: C1708272
•: Neoplastic Process

Synonym:

HIV-Lipodystrophy

Definition

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat. It is associated with antiretroviral therapy. Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHIV Lipodystrophy

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of connective tissue
    - Abnormal adipose tissue morphology
      - Lipodystrophy
        HIV Lipodystrophy

Professional guidelines

PubMed

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.

Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345 Free PMC Article

Metreleptin treatment of non-HIV lipodystrophy syndromes.

Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177

Rosiglitazone for treatment of HIV lipodystrophy.

Mikhail N
Ann Intern Med 2004 Nov 2;141(9):739; author reply 739-40. doi: 10.7326/0003-4819-141-9-200411020-00024. PMID: 15520438

See all (16)

Recent clinical studies

Etiology

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.

Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345 Free PMC Article

Metreleptin treatment of non-HIV lipodystrophy syndromes.

Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177

Genetic analysis implicates resistin in HIV lipodystrophy.

Ranade K, Geese WJ, Noor M, Flint O, Tebas P, Mulligan K, Powderly W, Grinspoon SK, Dube MP
AIDS 2008 Aug 20;22(13):1561-8. doi: 10.1097/QAD.0b013e32830a9886. PMID: 18670214 Free PMC Article

Plastic surgical options for HIV-associated lipodystrophy.

Nelson L, Stewart KJ
J Plast Reconstr Aesthet Surg 2008;61(4):359-65. Epub 2007 Dec 21 doi: 10.1016/j.bjps.2007.11.014. PMID: 18155655

Surgical algorithm for management of HIV lipodystrophy.

Davison SP, Timpone J Jr, Hannan CM
Plast Reconstr Surg 2007 Dec;120(7):1843-1858. doi: 10.1097/01.prs.0000267341.14550.a7. PMID: 18090746

See all (78)

Diagnosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.

Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345 Free PMC Article

Dermatological aspects of medicine: highly active antiretroviral therapy and the treatment of human immunodeficiency virus.

Finucane KA, Archer CB
Clin Exp Dermatol 2010 Jan;35(1):107-9. Epub 2009 Sep 15 doi: 10.1111/j.1365-2230.2009.03526.x. PMID: 19758384

HIV lipodystrophy and its metabolic consequences: implications for clinical practice.

Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641

Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.

Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810

HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.

Carr A
AIDS 2003 Apr;17 Suppl 1:S141-8. PMID: 12870540

See all (48)

Therapy

Metreleptin treatment of non-HIV lipodystrophy syndromes.

Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177

Metformin: the hidden chronicles of a magic drug.

Mahmood K, Naeem M, Rahimnajjad NA
Eur J Intern Med 2013 Jan;24(1):20-6. Epub 2012 Nov 21 doi: 10.1016/j.ejim.2012.10.011. PMID: 23177353

Genetic analysis implicates resistin in HIV lipodystrophy.

Ranade K, Geese WJ, Noor M, Flint O, Tebas P, Mulligan K, Powderly W, Grinspoon SK, Dube MP
AIDS 2008 Aug 20;22(13):1561-8. doi: 10.1097/QAD.0b013e32830a9886. PMID: 18670214 Free PMC Article

Plastic surgical options for HIV-associated lipodystrophy.

Nelson L, Stewart KJ
J Plast Reconstr Aesthet Surg 2008;61(4):359-65. Epub 2007 Dec 21 doi: 10.1016/j.bjps.2007.11.014. PMID: 18155655

HIV lipodystrophy etiology and pathogenesis. Body composition and metabolic alterations: etiology and pathogenesis.

Kotler DP
AIDS Read 2003 Apr;13(4 Suppl):S5-9. PMID: 12762287

See all (90)

Prognosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.

Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345 Free PMC Article

HIV lipodystrophy and its metabolic consequences: implications for clinical practice.

Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641

Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy.

Lindegaard B, Larsen LF, Hansen AB, Gerstoft J, Pedersen BK, Reue K
Int J Obes (Lond) 2007 Mar;31(3):449-56. Epub 2006 Jul 18 doi: 10.1038/sj.ijo.0803434. PMID: 16847472

Management of dyslipidemia in patients with complicated metabolic syndrome.

Davidson MH
Am J Cardiol 2005 Aug 22;96(4A):22E-25E. doi: 10.1016/j.amjcard.2005.05.011. PMID: 16098839

HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies.

Koutkia P, Grinspoon S
Annu Rev Med 2004;55:303-17. doi: 10.1146/annurev.med.55.091902.104412. PMID: 14746523

See all (24)

Clinical prediction guides

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.

Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345 Free PMC Article

Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy.

Domingo P, Giralt M, Gavaldà-Navarro A, Blasco-Roset A, Delgado-Anglés A, Gallego-Escuredo JM, Gutiérrez MDM, Mateo MG, Cereijo R, Domingo JC, Villarroya F, Villarroya J
Adipocyte 2022 Dec;11(1):143-152. doi: 10.1080/21623945.2022.2042962. PMID: 35300561 Free PMC Article

Metformin: the hidden chronicles of a magic drug.

Mahmood K, Naeem M, Rahimnajjad NA
Eur J Intern Med 2013 Jan;24(1):20-6. Epub 2012 Nov 21 doi: 10.1016/j.ejim.2012.10.011. PMID: 23177353

The association of lipodystrophy and oxidative stress biomarkers in HIV-infected men.

Vassimon HS, Deminice R, Machado AA, Monteiro JP, Jordao AA
Curr HIV Res 2010 Jul;8(5):364-9. doi: 10.2174/157016210791330347. PMID: 20353389

Cardiovascular complications in the acquired immunodeficiency syndrome.

Barbaro G, Silva EF
Rev Assoc Med Bras (1992) 2009 Sep-Oct;55(5):621-30. doi: 10.1590/s0104-42302009000500031. PMID: 19918668

See all (43)