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Papillary thyroid Microcarcinoma

MedGen UID:
313563
•Concept ID:
C1709457
•
Neoplastic Process
Synonym: Papillary Thyroid Microcarcinoma
 
Monarch Initiative: MONDO:0011368
OMIM®: 603744

Definition

A papillary carcinoma of the thyroid gland measuring 10mm or less in diameter. The survival rates of patients with this type of carcinoma are the same with those of the normal population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapillary thyroid Microcarcinoma

Professional guidelines

PubMed

Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
What is the best treatment of incidental papillary thyroid microcarcinoma?
Witt RL
Laryngoscope 2016 Oct;126(10):2203-4. Epub 2016 Apr 23 doi: 10.1002/lary.26049. PMID: 27107211
Practice patterns in the surgical treatment of papillary thyroid microcarcinoma.
Nguyen C, Wang M
Thyroid 2014 Dec;24(12):1816-7. doi: 10.1089/thy.2014.0388. PMID: 25232803

Recent clinical studies

Etiology

Microwave Ablation for Papillary Thyroid Microcarcinoma with and without US-detected Capsule Invasion: A Multicenter Prospective Cohort Study.
Zheng L, Dou JP, Han ZY, Liu FY, Yu J, Cheng ZG, Yu XL, Wang H, Cong ZB, Wang SR, Yu MA, Xu ZF, Che Y, Nan B, Liu C, Hao Y, Wang X, Liu Y, Zhou Y, Liang P
Radiology 2023 May;307(3):e220661. Epub 2023 Mar 7 doi: 10.1148/radiol.220661. PMID: 36880949
Active Surveillance of Thyroid Microcarcinomas: a Critical View.
Cernea CR, Matos LL, Eugênio C, Ferreira GM, Cerqueira YS, Leite AKN, Vanderlei FAB, de Carlucci D, Gotoda RN, Hojaij FC, Araújo-Filho VJF
Curr Oncol Rep 2022 Jan;24(1):69-76. Epub 2022 Jan 21 doi: 10.1007/s11912-021-01177-w. PMID: 35061193
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
Active Surveillance of Thyroid Microcarcinoma-Can This Approach Be Safely Implemented Worldwide?
Pollack R, Mazeh H
J Surg Res 2021 Feb;258:145-152. Epub 2020 Sep 30 doi: 10.1016/j.jss.2020.08.061. PMID: 33010560
Low-risk papillary thyroid microcarcinoma: Optimal management toward a more conservative approach.
Ramundo V, Sponziello M, Falcone R, Verrienti A, Filetti S, Durante C, Grani G
J Surg Oncol 2020 May;121(6):958-963. Epub 2020 Mar 18 doi: 10.1002/jso.25848. PMID: 32189352

Diagnosis

Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Low-risk papillary thyroid microcarcinoma: Optimal management toward a more conservative approach.
Ramundo V, Sponziello M, Falcone R, Verrienti A, Filetti S, Durante C, Grani G
J Surg Oncol 2020 May;121(6):958-963. Epub 2020 Mar 18 doi: 10.1002/jso.25848. PMID: 32189352
Thyroid Follicular Microcarcinoma.
Handra-Luca A
Int J Surg Pathol 2018 May;26(3):236-237. Epub 2017 Sep 28 doi: 10.1177/1066896917733102. PMID: 28954568
Current treatment of papillary thyroid microcarcinoma.
Yu XM, Lloyd R, Chen H
Adv Surg 2012;46:191-203. doi: 10.1016/j.yasu.2012.03.002. PMID: 22873040

Therapy

Response to Xiang and Zhang re: "Active Surveillance Outcomes of Patients with Low-Risk Papillary Thyroid Microcarcinoma According to Levothyroxine Treatment Status".
Miyauchi A
Thyroid 2024 Mar;34(3):400-401. Epub 2024 Feb 13 doi: 10.1089/thy.2023.0697. PMID: 38226613
US Predictors of Papillary Thyroid Microcarcinoma Progression at Active Surveillance.
Lee JY, Kim JH, Kim YK, Lee CY, Lee EK, Moon JH, Choi HS, Yul H, Cho SW, Kim SJ, Lee KE, Park DJ, Park YJ
Radiology 2023 Oct;309(1):e230006. doi: 10.1148/radiol.230006. PMID: 37906009
Microwave Ablation for Papillary Thyroid Microcarcinoma with and without US-detected Capsule Invasion: A Multicenter Prospective Cohort Study.
Zheng L, Dou JP, Han ZY, Liu FY, Yu J, Cheng ZG, Yu XL, Wang H, Cong ZB, Wang SR, Yu MA, Xu ZF, Che Y, Nan B, Liu C, Hao Y, Wang X, Liu Y, Zhou Y, Liang P
Radiology 2023 May;307(3):e220661. Epub 2023 Mar 7 doi: 10.1148/radiol.220661. PMID: 36880949
Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Papillary thyroid microcarcinoma: optimal management versus overtreatment.
Walgama E, Sacks WL, Ho AS
Curr Opin Oncol 2020 Jan;32(1):1-6. doi: 10.1097/CCO.0000000000000595. PMID: 31633497

Prognosis

Risk prediction for <1 cm lateral lymph node metastasis in papillary thyroid microcarcinoma.
Zhang C, Fu S, Liu H, Xue S
Front Endocrinol (Lausanne) 2023;14:1235354. Epub 2023 Nov 13 doi: 10.3389/fendo.2023.1235354. PMID: 38027093Free PMC Article
Long-Term Outcomes of Active Surveillance and Immediate Surgery for Adult Patients with Low-Risk Papillary Thyroid Microcarcinoma: 30-Year Experience.
Miyauchi A, Ito Y, Fujishima M, Miya A, Onoda N, Kihara M, Higashiyama T, Masuoka H, Kawano S, Sasaki T, Nishikawa M, Fukata S, Akamizu T, Ito M, Nishihara E, Hisakado M, Kosaka K, Hirokawa M, Hayashi T
Thyroid 2023 Jul;33(7):817-825. Epub 2023 May 29 doi: 10.1089/thy.2023.0076. PMID: 37166389Free PMC Article
Active Surveillance of Thyroid Microcarcinomas: a Critical View.
Cernea CR, Matos LL, Eugênio C, Ferreira GM, Cerqueira YS, Leite AKN, Vanderlei FAB, de Carlucci D, Gotoda RN, Hojaij FC, Araújo-Filho VJF
Curr Oncol Rep 2022 Jan;24(1):69-76. Epub 2022 Jan 21 doi: 10.1007/s11912-021-01177-w. PMID: 35061193
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
Insights and clinical questions about the active surveillance of low-risk papillary thyroid microcarcinomas [Review].
Ito Y, Oda H, Miyauchi A
Endocr J 2016 Apr 25;63(4):323-8. Epub 2015 Dec 2 doi: 10.1507/endocrj.EJ15-0637. PMID: 26632168

Clinical prediction guides

US Predictors of Papillary Thyroid Microcarcinoma Progression at Active Surveillance.
Lee JY, Kim JH, Kim YK, Lee CY, Lee EK, Moon JH, Choi HS, Yul H, Cho SW, Kim SJ, Lee KE, Park DJ, Park YJ
Radiology 2023 Oct;309(1):e230006. doi: 10.1148/radiol.230006. PMID: 37906009
Long-Term Outcomes of Active Surveillance and Immediate Surgery for Adult Patients with Low-Risk Papillary Thyroid Microcarcinoma: 30-Year Experience.
Miyauchi A, Ito Y, Fujishima M, Miya A, Onoda N, Kihara M, Higashiyama T, Masuoka H, Kawano S, Sasaki T, Nishikawa M, Fukata S, Akamizu T, Ito M, Nishihara E, Hisakado M, Kosaka K, Hirokawa M, Hayashi T
Thyroid 2023 Jul;33(7):817-825. Epub 2023 May 29 doi: 10.1089/thy.2023.0076. PMID: 37166389Free PMC Article
Microwave Ablation for Papillary Thyroid Microcarcinoma with and without US-detected Capsule Invasion: A Multicenter Prospective Cohort Study.
Zheng L, Dou JP, Han ZY, Liu FY, Yu J, Cheng ZG, Yu XL, Wang H, Cong ZB, Wang SR, Yu MA, Xu ZF, Che Y, Nan B, Liu C, Hao Y, Wang X, Liu Y, Zhou Y, Liang P
Radiology 2023 May;307(3):e220661. Epub 2023 Mar 7 doi: 10.1148/radiol.220661. PMID: 36880949
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm.
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364

Recent systematic reviews

Risk factors for tumor enlargement in low-risk papillary thyroid microcarcinoma patients: a systematic review and meta-analysis.
Luo N, Shi X, Xia Y, Gao L, Li X, Jiang Y
Endocrine 2024 Sep;85(3):1041-1049. Epub 2024 Apr 10 doi: 10.1007/s12020-024-03812-5. PMID: 38600392
Thermal ablation for multifocal papillary thyroid microcarcinoma: a systematic review and meta-analysis.
Zhang J, Liu J, Yi W, Liu Y, Liu Y, Xu J
Endocrine 2024 Jul;85(1):35-43. Epub 2024 Feb 6 doi: 10.1007/s12020-024-03710-w. PMID: 38319587
Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma: A systematic review.
Chen Z, Zhang W, He W
Clin Endocrinol (Oxf) 2023 Mar;98(3):296-305. Epub 2022 Dec 12 doi: 10.1111/cen.14857. PMID: 36471482
Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis.
Lincango-Naranjo E, Solis-Pazmino P, El Kawkgi O, Salazar-Vega J, Garcia C, Ledesma T, Rojas T, Alvarado-Mafla B, Young G, Dy B, Ponce OJ, Brito JP
Endocrine 2021 Jun;72(3):644-659. Epub 2021 Jan 29 doi: 10.1007/s12020-020-02588-8. PMID: 33512656

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