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Colorectal medullary carcinoma

MedGen UID:
317525
•Concept ID:
C1707438
•
Neoplastic Process
Synonyms: Colorectal Medullary Carcinoma; colorectal medullary carcinoma
 
Monarch Initiative: MONDO:0020794

Definition

A rare, invasive colorectal adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal medullary carcinoma

Professional guidelines

PubMed

Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.
Inaguma S, Lasota J, Wang Z, Felisiak-Golabek A, Ikeda H, Miettinen M
Mod Pathol 2017 Feb;30(2):278-285. Epub 2016 Nov 4 doi: 10.1038/modpathol.2016.185. PMID: 27813511Free PMC Article
Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer.
Rowe CW, Bendinelli C, McGrath S
Clin Endocrinol (Oxf) 2016 Sep;85(3):340-3. Epub 2016 Jun 29 doi: 10.1111/cen.13114. PMID: 27230389

Recent clinical studies

Etiology

Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.
Lee LH, Yantiss RK, Sadot E, Ren B, Calvacanti MS, Hechtman JF, Ivelja S, Huynh B, Xue Y, Shitilbans T, Guend H, Stadler ZK, Weiser MR, Vakiani E, Gönen M, Klimstra DS, Shia J
Hum Pathol 2017 Apr;62:74-82. Epub 2016 Dec 26 doi: 10.1016/j.humpath.2016.12.013. PMID: 28034727Free PMC Article

Diagnosis

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.
Kaneko M, Nakashima M, Sugiura K, Ishida N, Tamura S, Tani S, Yamade M, Hamaya Y, Osawa S, Tatsuta K, Kurachi K, Baba S, Iwashita Y, Arai T, Sugimura H, Maekawa M, Sugimoto K, Iwaizumi M
Medicine (Baltimore) 2023 Sep 22;102(38):e35022. doi: 10.1097/MD.0000000000035022. PMID: 37746995Free PMC Article
Colorectal medullary carcinoma: heterogeneous presentations of a rare clinico-pathological entity. Report of two cases.
Romanzi A, Centonze G, Sabella G, Cattaneo L, Battiston C, Lorenzo ND, Milanesi M, Putortì A, Rossi F, Scolaro R, Zanardo M, Vignati B, Vannelli A
Tumori 2022 Dec;108(6):NP20-NP25. Epub 2022 Mar 20 doi: 10.1177/03008916221082996. PMID: 35311395
Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.
Lee LH, Yantiss RK, Sadot E, Ren B, Calvacanti MS, Hechtman JF, Ivelja S, Huynh B, Xue Y, Shitilbans T, Guend H, Stadler ZK, Weiser MR, Vakiani E, Gönen M, Klimstra DS, Shia J
Hum Pathol 2017 Apr;62:74-82. Epub 2016 Dec 26 doi: 10.1016/j.humpath.2016.12.013. PMID: 28034727Free PMC Article

Therapy

Colorectal medullary carcinoma: a pathological subtype with intense immune response and potential to benefit from immune checkpoint inhibitors.
Zou H, Liu C, Ruan Y, Fang L, Wu T, Han S, Dang T, Meng H, Zhang Y
Expert Rev Clin Immunol 2024 Aug;20(8):997-1008. Epub 2024 Mar 13 doi: 10.1080/1744666X.2024.2328746. PMID: 38459764

Prognosis

Colorectal medullary carcinoma: heterogeneous presentations of a rare clinico-pathological entity. Report of two cases.
Romanzi A, Centonze G, Sabella G, Cattaneo L, Battiston C, Lorenzo ND, Milanesi M, Putortì A, Rossi F, Scolaro R, Zanardo M, Vignati B, Vannelli A
Tumori 2022 Dec;108(6):NP20-NP25. Epub 2022 Mar 20 doi: 10.1177/03008916221082996. PMID: 35311395
Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.
Lee LH, Yantiss RK, Sadot E, Ren B, Calvacanti MS, Hechtman JF, Ivelja S, Huynh B, Xue Y, Shitilbans T, Guend H, Stadler ZK, Weiser MR, Vakiani E, Gönen M, Klimstra DS, Shia J
Hum Pathol 2017 Apr;62:74-82. Epub 2016 Dec 26 doi: 10.1016/j.humpath.2016.12.013. PMID: 28034727Free PMC Article

Clinical prediction guides

Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study.
Kaneko M, Nakashima M, Sugiura K, Ishida N, Tamura S, Tani S, Yamade M, Hamaya Y, Osawa S, Tatsuta K, Kurachi K, Baba S, Iwashita Y, Arai T, Sugimura H, Maekawa M, Sugimoto K, Iwaizumi M
Medicine (Baltimore) 2023 Sep 22;102(38):e35022. doi: 10.1097/MD.0000000000035022. PMID: 37746995Free PMC Article
Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.
Lee LH, Yantiss RK, Sadot E, Ren B, Calvacanti MS, Hechtman JF, Ivelja S, Huynh B, Xue Y, Shitilbans T, Guend H, Stadler ZK, Weiser MR, Vakiani E, Gönen M, Klimstra DS, Shia J
Hum Pathol 2017 Apr;62:74-82. Epub 2016 Dec 26 doi: 10.1016/j.humpath.2016.12.013. PMID: 28034727Free PMC Article

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