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Central nervous system hibernoma

MedGen UID:
317749
•Concept ID:
C1708362
•
Neoplastic Process
Synonyms: Central Nervous System Hibernoma; central nervous system hibernoma; Hibernoma of Central Nervous System; hibernoma of central nervous system; hibernoma of nervous system; Hibernoma of the Central Nervous System; hibernoma of the central nervous system; nervous system hibernoma
 
Monarch Initiative: MONDO:0003943

Definition

A central nervous system benign and slow growing adipose tissue tumor characterized by the presence of polygonal brown fat cells with abundant cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system hibernoma

Professional guidelines

PubMed

Tethered cord syndrome: overview of diagnosis and treatment.
Yamada S, Won DJ, Siddiqi J, Yamada SM
Neurol Res 2004 Oct;26(7):719-21. doi: 10.1179/016164104225017947. PMID: 15494110
Pre-natal diagnosis of occult spinal dysraphism by ultrasonography and post-natal evaluation by MR scanning.
Sattar TS, Bannister CM, Russell SA, Rimmer S
Eur J Pediatr Surg 1998 Dec;8 Suppl 1:31-3. doi: 10.1055/s-2008-1071249. PMID: 9926321
The median cleft face syndrome. Differential diagnosis of cranium bifidum occultum, hypertelorism, and median cleft nose, lip, and palate.
DeMyer W
Neurology 1967 Oct;17(10):961-71. doi: 10.1212/wnl.17.10.961. PMID: 6069608

Recent clinical studies

Etiology

Prevention and treatment of CSF leaks in congenital complex spinal lipomas.
Lim JX, Low SY, Ng LP, Seow WT
Acta Neurochir (Wien) 2022 Apr;164(4):1157-1160. Epub 2022 Jan 11 doi: 10.1007/s00701-021-05095-5. PMID: 35015155
Combined Spinal Arteriovenous Malformation and Spinal Dysraphism.
Islak C, Kandemirli SG, Kizilkilic O, Kocer N, Tuzgen S, Hanci MM
World Neurosurg 2018 Feb;110:407-413. Epub 2017 Dec 6 doi: 10.1016/j.wneu.2017.11.162. PMID: 29223517
Split-cord malformation and accompanying anomalies.
Ozturk E, Sonmez G, Mutlu H, Sildiroglu HO, Velioglu M, Basekim CC, Kizilkaya E
J Neuroradiol 2008 Jul;35(3):150-6. Epub 2008 Feb 21 doi: 10.1016/j.neurad.2007.11.006. PMID: 18206241
Parietal lipomeningocele--case report.
Yamashita S, Kunishio K, Tamiya T, Nakamura T, Ogawa D, Igawa HH, Kuroda Y, Nagao S
Neurol Med Chir (Tokyo) 2005 Feb;45(2):112-5. doi: 10.2176/nmc.45.112. PMID: 15722612
Intradural lipoma.
Schubert F
Australas Radiol 1996 Feb;40(1):61-4. doi: 10.1111/j.1440-1673.1996.tb00347.x. PMID: 8838891

Diagnosis

CLOVE Syndrome.
Kasinathan A, Sankhyan N, Ahuja CK, Singhi P
Indian J Pediatr 2018 Jan;85(1):79-80. Epub 2017 Jul 28 doi: 10.1007/s12098-017-2416-z. PMID: 28752282
Multiple primary liponeurocytoma of the central nervous system.
Konovalov AN, Konovalov NA, Pronin IN, Shishkina LV, Zolotova LI, Yakovlenko YG, Korolishin VA, Onoprienko RA, Timonin SY
Zh Vopr Neirokhir Im N N Burdenko 2015;79(2):87-96. doi: 10.17116/neiro201579287-96. PMID: 26146048
Nonschwannoma tumors of the cerebellopontine angle.
Friedmann DR, Grobelny B, Golfinos JG, Roland JT Jr
Otolaryngol Clin North Am 2015 Jun;48(3):461-75. doi: 10.1016/j.otc.2015.02.006. PMID: 26043142
Exercise-induced headache.
Targett C
Emerg Med J 2014 May;31(5):438. Epub 2013 May 16 doi: 10.1136/emermed-2013-202725. PMID: 23682097
Intracranial lipomas.
Eghwrudjakpor PO, Kurisaka M, Fukuoka M, Mori K
Acta Neurochir (Wien) 1991;110(3-4):124-8. doi: 10.1007/BF01400679. PMID: 1927603

Therapy

Nerve Transfer for Facial Paralysis Under Intravenous Sedation and Local Analgesia for the High Surgical Risk Elderly Patient.
Rubi C, Cardenas Mejia A, Cavadas PC, Thione A, Aramburo Garcia R, Rozen S
World Neurosurg 2016 Jul;91:670.e13-5. Epub 2016 Apr 7 doi: 10.1016/j.wneu.2016.03.091. PMID: 27060514
Corpus callosum lipoma.
Rajan DS, Popescu A
Neurology 2012 Apr 24;78(17):1366. doi: 10.1212/WNL.0b013e318251838b. PMID: 22529205
Sturge-Weber syndrome accompanied with multiple congenital intracranial lesions.
Ergün R, Okten AI, Gezercan Y, Gezici AR
Acta Neurochir (Wien) 2007 Aug;149(8):829-30; discussion 830. Epub 2007 Aug 1 doi: 10.1007/s00701-007-1224-z. PMID: 17660941
The biological resolution of malformations of the central nervous system.
McLone DG
Neurosurgery 1998 Dec;43(6):1375-80; discussion 1380-1. doi: 10.1097/00006123-199812000-00071. PMID: 9848852
Metrizamide in pediatric myelography.
Barry JF, Harwood-Nash DC, Fitz CR, Byrd SE, Boldt DW
Radiology 1977 Aug;124(2):409-18. doi: 10.1148/124.2.409. PMID: 877281

Prognosis

Prenatal Diagnosis of Diastematomyelia: a Case Report and Literature Review.
Arbelo-Pérez P, de Ganzo-Suárez T, de Luis-Escudero JF
Reprod Sci 2023 Dec;30(12):3563-3567. Epub 2023 Jul 25 doi: 10.1007/s43032-023-01307-8. PMID: 37491555
Trigeminal neuralgia associated with cerebellopontine angle lipoma in childhood.
Egemen E, Börcek AÖ, Karaaslan B, Baykaner MK
Pediatr Neurosurg 2012;48(5):306-9. Epub 2013 Jun 21 doi: 10.1159/000351550. PMID: 23796885
Split-cord malformation and accompanying anomalies.
Ozturk E, Sonmez G, Mutlu H, Sildiroglu HO, Velioglu M, Basekim CC, Kizilkaya E
J Neuroradiol 2008 Jul;35(3):150-6. Epub 2008 Feb 21 doi: 10.1016/j.neurad.2007.11.006. PMID: 18206241
Parietal lipomeningocele--case report.
Yamashita S, Kunishio K, Tamiya T, Nakamura T, Ogawa D, Igawa HH, Kuroda Y, Nagao S
Neurol Med Chir (Tokyo) 2005 Feb;45(2):112-5. doi: 10.2176/nmc.45.112. PMID: 15722612
Intradural lipoma.
Schubert F
Australas Radiol 1996 Feb;40(1):61-4. doi: 10.1111/j.1440-1673.1996.tb00347.x. PMID: 8838891

Clinical prediction guides

Liponeurocytoma: Systematic Review of a Rare Entity.
Gembruch O, Junker A, Mönninghoff C, Ahmadipour Y, Darkwah Oppong M, Sure U, El Hindy N, Lemonas E
World Neurosurg 2018 Dec;120:214-233. Epub 2018 Sep 8 doi: 10.1016/j.wneu.2018.09.001. PMID: 30205225
Should incidental findings in diagnostic imaging be reported?
Panelli Santos KC, Fujita M, Oliveira JX, Yanagi Y, Asaumi J
Minerva Stomatol 2017 Apr;66(2):75-80. Epub 2016 Dec 14 doi: 10.23736/S0026-4970.17.03971-1. PMID: 27973465
Intracranial lipomas: clinical appearances on neuroimaging and clinical significance.
Jabot G, Stoquart-Elsankari S, Saliou G, Toussaint P, Deramond H, Lehmann P
J Neurol 2009 Jun;256(6):851-5. Epub 2009 Mar 12 doi: 10.1007/s00415-009-5087-5. PMID: 19280105
Spectrum of corpus callosum agenesis.
Sztriha L
Pediatr Neurol 2005 Feb;32(2):94-101. doi: 10.1016/j.pediatrneurol.2004.09.007. PMID: 15664768
Lipomas of the corpus callosum and epilepsy.
Gastaut H, Regis H, Gastaut JL, Yermenos E, Low MD
Neurology 1980 Feb;30(2):132-8. doi: 10.1212/wnl.30.2.132. PMID: 7188793

Recent systematic reviews

Diprosopus: A Rare Case of Craniofacial Duplication and a Systematic Review of the Literature.
Trevisani V, Balestri E, Napoli M, Caraffi SG, Baroni MC, Peluso F, Colonna A, Iughetti L, Gargano G, Superti-Furga A, Garavelli L
Genes (Basel) 2023 Aug 31;14(9) doi: 10.3390/genes14091745. PMID: 37761885Free PMC Article
Lateral ventricular liponeurocytoma: Review of literature and case illustration.
Al-Umran MR, Al-Umran SR, Arab AF, Dababo MA, Alotaibi FA
Neurochirurgie 2021 Nov;67(6):579-586. Epub 2021 Mar 22 doi: 10.1016/j.neuchi.2021.03.004. PMID: 33766564
Cerebellopontine Angle and Internal Auditory Canal Lipomas: Case Series and Systematic Review.
Totten DJ, Manzoor NF, Perkins EL, Labadie RF, Bennett ML, Haynes DS
Laryngoscope 2021 Sep;131(9):2081-2087. Epub 2021 Feb 10 doi: 10.1002/lary.29434. PMID: 33567134
Liponeurocytoma: Systematic Review of a Rare Entity.
Gembruch O, Junker A, Mönninghoff C, Ahmadipour Y, Darkwah Oppong M, Sure U, El Hindy N, Lemonas E
World Neurosurg 2018 Dec;120:214-233. Epub 2018 Sep 8 doi: 10.1016/j.wneu.2018.09.001. PMID: 30205225
Central nervous system anomalies in craniofacial microsomia: a systematic review.
Renkema RW, Caron CJJM, Wolvius EB, Dunaway DJ, Forrest CR, Padwa BL, Koudstaal MJ
Int J Oral Maxillofac Surg 2018 Jan;47(1):27-34. Epub 2017 Jul 20 doi: 10.1016/j.ijom.2017.06.009. PMID: 28736116

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