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Macrofollicular Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
317865
•Concept ID:
C1708851
•
Neoplastic Process

Definition

A morphologic variant of papillary carcinoma of the thyroid gland characterized by the predominance or the exclusive presence of macrofollicles. Some of the malignant follicular cells display the nuclear features that characterize the papillary adenocarcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMacrofollicular Variant Thyroid Gland Papillary Carcinoma

Professional guidelines

PubMed

Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study.
Condello V, Roberts JW, Stenman A, Larsson C, Viswanathan K, Juhlin CC
Virchows Arch 2024 Jul;485(1):105-114. Epub 2024 Apr 19 doi: 10.1007/s00428-024-03802-y. PMID: 38637342Free PMC Article

Recent clinical studies

Etiology

Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma.
Andriescu EC, Căruntu ID, Giuşcă SE, Lozneanu L, Ciobanu Apostol DG
Rom J Morphol Embryol 2018;59(3):721-727. PMID: 30534810
Ultrasonographic features and clinicopathologic characteristics of macrofollicular variant papillary thyroid carcinoma.
Lee YS, Kim SY, Hong SW, Kim SM, Kim BW, Chang HS, Park CS
Medicine (Baltimore) 2018 Mar;97(9):e8105. doi: 10.1097/MD.0000000000008105. PMID: 29489673Free PMC Article
Clinicopathological profile of papillary carcinoma of thyroid: A 10-year experience in a tertiary care institute in North Karnataka, India.
Rao R, Giriyan SS, Rangappa PK
Indian J Cancer 2017 Jul-Sep;54(3):514-518. doi: 10.4103/ijc.IJC_337_17. PMID: 29798949
Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma.
Giusca SE, Amalinei C, Lozneanu L, Ciobanu Apostol D, Andriescu EC, Scripcariu A, Balan R, Avadanei ER, Căruntu ID
Biomed Res Int 2017;2017:8701386. Epub 2017 Dec 25 doi: 10.1155/2017/8701386. PMID: 29435461Free PMC Article
Strong expression of HBME-1 associates with high-risk clinicopathological factors of papillary thyroid carcinoma.
Dencic TM, Savin SB, Selemetjev SA, Paskas SD, Zivaljevic VR, Bozic VD, Cvejic DS
Pathol Oncol Res 2015 Jul;21(3):735-42. Epub 2015 Jan 11 doi: 10.1007/s12253-014-9883-6. PMID: 25577274

Diagnosis

Macrofollicular Architecture in Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Pitfall in Thyroid Practice.
Yadav S, Kandasamy D, Damle N, Goel R, Chumber S, Sharma MC, Boruah M, Agarwal S
Head Neck Pathol 2023 Dec;17(4):899-909. Epub 2023 Sep 29 doi: 10.1007/s12105-023-01584-4. PMID: 37775618Free PMC Article
Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Juhlin CC, Stenman A, Zedenius J
Histopathology 2021 Oct;79(4):661-666. Epub 2021 Aug 3 doi: 10.1111/his.14416. PMID: 34008223
Evergreen influenza - Tackling an old enemy with fresh munitions.
Häfner SJ
Biomed J 2019 Feb;42(1):1-4. doi: 10.1016/j.bj.2019.02.005. PMID: 30987700Free PMC Article
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Macrofollicular variant of papillary thyroid carcinoma with extensive lymph node metastases.
Yeo MK, Bae JS, Oh WJ, Park GS, Jung CK
Endocr Pathol 2014 Sep;25(3):265-72. doi: 10.1007/s12022-014-9306-y. PMID: 24671758

Therapy

Remarkable response to radioiodine therapy in a case of metastatic macrofollicular variant of papillary thyroid carcinoma.
Marques P, Leite V, Bugalho MJ
Clin Nucl Med 2014 Feb;39(2):219-21. doi: 10.1097/RLU.0000000000000322. PMID: 24368535

Prognosis

Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Macrofollicular variant of papillary thyroid carcinoma with extensive lymph node metastases.
Yeo MK, Bae JS, Oh WJ, Park GS, Jung CK
Endocr Pathol 2014 Sep;25(3):265-72. doi: 10.1007/s12022-014-9306-y. PMID: 24671758
Two patients with highly aggressive macrofollicular variant of papillary thyroid carcinoma.
Cardenas MG, Kini S, Wisgerhof M
Thyroid 2009 Apr;19(4):413-6. doi: 10.1089/thy.2008.0178. PMID: 19355832
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576
Macrofollicular variant of papillary thyroid carcinoma with minor insular component.
Albores-Saavedra J, Housini I, Vuitch F, Snyder WH 3rd
Cancer 1997 Sep 15;80(6):1110-6. doi: 10.1002/(sici)1097-0142(19970915)80:6<1110::aid-cncr14>3.0.co;2-b. PMID: 9305712

Clinical prediction guides

Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Juhlin CC, Stenman A, Zedenius J
Histopathology 2021 Oct;79(4):661-666. Epub 2021 Aug 3 doi: 10.1111/his.14416. PMID: 34008223
Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma.
Bongiovanni M, Sykiotis GP, La Rosa S, Bisig B, Trimech M, Missiaglia E, Gremaud M, Salvatori Chappuis V, De Vito C, Sciarra A, Foulkes WD, Pusztaszeri M
Thyroid 2020 Jan;30(1):72-80. Epub 2019 Dec 30 doi: 10.1089/thy.2018.0607. PMID: 31701808
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Strong expression of HBME-1 associates with high-risk clinicopathological factors of papillary thyroid carcinoma.
Dencic TM, Savin SB, Selemetjev SA, Paskas SD, Zivaljevic VR, Bozic VD, Cvejic DS
Pathol Oncol Res 2015 Jul;21(3):735-42. Epub 2015 Jan 11 doi: 10.1007/s12253-014-9883-6. PMID: 25577274
Macrofollicular variant of papillary carcinoma: a potential thyroid FNA pitfall.
Chung D, Ghossein RA, Lin O
Diagn Cytopathol 2007 Sep;35(9):560-4. doi: 10.1002/dc.20702. PMID: 17703452

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