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Glipizide response

MedGen UID:
322023
Concept ID:
C1832730
Finding
Synonym: Glipizide poor metabolizer
Drug:
Glipizide
MedGen UID:
4900
Concept ID:
C0017642
Pharmacologic Substance
A short-acting, second-generation sulfonylurea with hypoglycemic activity. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine. [from NCI]
 
Gene (location): G6PD (Xq28)
 
OMIM®: 601130

Professional guidelines

PubMed

Tomlinson B, Li YH, Chan P
Expert Opin Pharmacother 2022 Dec;23(17):1869-1877. Epub 2022 Nov 10 doi: 10.1080/14656566.2022.2141108. PMID: 36300277
Gianchandani RY, Neupane S, Iyengar JJ, Heung M
Endocr Pract 2017 Mar;23(3):353-362. Epub 2016 Dec 14 doi: 10.4158/EP161471.RA. PMID: 27967230
Choy M, Lam S
Cardiol Rev 2007 Sep-Oct;15(5):264-71. doi: 10.1097/CRD.0b013e318123f771. PMID: 17700385

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

DailyMed Drug Label, glipizide, 2022

DailyMed Drug Label, GLIPIZIDE, 2019

Recent clinical studies

Etiology

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A; MAGIC Investigators; Diabetes Prevention Program (DPP) Research Group, Udler MS, Leong A, Mercader JM, Florez JC
Diabetologia 2023 Jul;66(7):1260-1272. Epub 2023 May 26 doi: 10.1007/s00125-023-05922-7. PMID: 37233759Free PMC Article
Abdul-Ghani T, Puckett C, Migahid O, Abdelgani S, Migahed A, Adams J, Triplitt C, DeFronzo R, Jayyousi A, Abdul-Ghani M
Diabetes Obes Metab 2022 Sep;24(9):1810-1818. Epub 2022 Jun 29 doi: 10.1111/dom.14767. PMID: 35581905
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Melander A
Diabet Med 1996 Sep;13(9 Suppl 6):S143-7. PMID: 8894498
Melander A
Metabolism 1987 Feb;36(2 Suppl 1):12-6. doi: 10.1016/0026-0495(87)90195-8. PMID: 3543616

Diagnosis

Abdul-Ghani T, Puckett C, Migahid O, Abdelgani S, Migahed A, Adams J, Triplitt C, DeFronzo R, Jayyousi A, Abdul-Ghani M
Diabetes Obes Metab 2022 Sep;24(9):1810-1818. Epub 2022 Jun 29 doi: 10.1111/dom.14767. PMID: 35581905
Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
J Clin Endocrinol Metab 2021 Nov 19;106(12):3497-3504. doi: 10.1210/clinem/dgab403. PMID: 34343296Free PMC Article
Rendell M
Drugs 2004;64(12):1339-58. doi: 10.2165/00003495-200464120-00006. PMID: 15200348
Melander A
Diabet Med 1996 Sep;13(9 Suppl 6):S143-7. PMID: 8894498
Groop L, Wåhlin-Boll E, Groop PH, Tötterman KJ, Melander A, Tolppanen EM, Fyhrqvist F
Eur J Clin Pharmacol 1985;28(6):697-704. doi: 10.1007/BF00607919. PMID: 3933984

Therapy

Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A; MAGIC Investigators; Diabetes Prevention Program (DPP) Research Group, Udler MS, Leong A, Mercader JM, Florez JC
Diabetologia 2023 Jul;66(7):1260-1272. Epub 2023 May 26 doi: 10.1007/s00125-023-05922-7. PMID: 37233759Free PMC Article
Abdul-Ghani T, Puckett C, Migahid O, Abdelgani S, Migahed A, Adams J, Triplitt C, DeFronzo R, Jayyousi A, Abdul-Ghani M
Diabetes Obes Metab 2022 Sep;24(9):1810-1818. Epub 2022 Jun 29 doi: 10.1111/dom.14767. PMID: 35581905
Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGen Plus, for the DIRECT Consortium; MetGen Plus investigators:
Diabetes Care 2021 Dec;44(12):2673-2682. Epub 2021 Oct 4 doi: 10.2337/dc21-1152. PMID: 34607834Free PMC Article
Lyseng-Williamson KA
Drugs 2007;67(4):587-97. doi: 10.2165/00003495-200767040-00007. PMID: 17352516
Shuman CR
Am J Med 1983 Nov 30;75(5B):55-9. doi: 10.1016/0002-9343(83)90254-1. PMID: 6369968

Prognosis

Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
J Clin Endocrinol Metab 2021 Nov 19;106(12):3497-3504. doi: 10.1210/clinem/dgab403. PMID: 34343296Free PMC Article
Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
Diabetes Obes Metab 2021 Jul;23(7):1631-1639. Epub 2021 May 6 doi: 10.1111/dom.14383. PMID: 33852204Free PMC Article
Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J, Draviam VM
PLoS One 2015;10(10):e0139446. Epub 2015 Oct 9 doi: 10.1371/journal.pone.0139446. PMID: 26452147Free PMC Article
Abraira C, Henderson WG, Colwell JA, Nuttall FQ, Comstock JP, Emanuele NV, Levin SR, Sawin CT, Silbert CK
Diabetes Care 1998 Apr;21(4):574-9. doi: 10.2337/diacare.21.4.574. PMID: 9571345
Almér LO, Johansson E, Melander A, Wåhlin-Boll E
Eur J Clin Pharmacol 1982;22(1):27-32. doi: 10.1007/BF00606421. PMID: 7047169

Clinical prediction guides

Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGen Plus, for the DIRECT Consortium; MetGen Plus investigators:
Diabetes Care 2021 Dec;44(12):2673-2682. Epub 2021 Oct 4 doi: 10.2337/dc21-1152. PMID: 34607834Free PMC Article
Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
J Clin Endocrinol Metab 2021 Nov 19;106(12):3497-3504. doi: 10.1210/clinem/dgab403. PMID: 34343296Free PMC Article
Urbanova J, Andel M, Potockova J, Klima J, Macek J, Ptacek P, Mat'oska V, Kumstyrova T, Heneberg P
Curr Pharm Des 2015;21(39):5736-48. doi: 10.2174/1381612821666151008124036. PMID: 26446475
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Shuman CR
Am J Med 1983 Nov 30;75(5B):55-9. doi: 10.1016/0002-9343(83)90254-1. PMID: 6369968

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2022
      DailyMed Drug Label, glipizide, 2022
    • DailyMed Drug Label, 2019
      DailyMed Drug Label, GLIPIZIDE, 2019

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