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Radiation-Recall Dermatitis

MedGen UID:
328379
•Concept ID:
C1720798
•
Disease or Syndrome
Synonyms: Dermatitides, Radiation Recall; Dermatitis, Radiation Recall; Radiation Recall Dermatitides; Radiation Recall Dermatitis; Radiation Recall Reaction; Radiation Recall Reactions; Reaction, Radiation Recall; Reactions, Radiation Recall; Recall Reaction, Radiation; Recall Reactions, Radiation

Definition

Acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmacologic agent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation-Recall Dermatitis

Professional guidelines

PubMed

Radiation-induced skin injury: pathogenesis, treatment, and management.
Yang X, Ren H, Guo X, Hu C, Fu J
Aging (Albany NY) 2020 Nov 16;12(22):23379-23393. doi: 10.18632/aging.103932. PMID: 33202382Free PMC Article
Radiation-Induced Skin Fibrosis: Pathogenesis, Current Treatment Options, and Emerging Therapeutics.
Borrelli MR, Shen AH, Lee GK, Momeni A, Longaker MT, Wan DC
Ann Plast Surg 2019 Oct;83(4S Suppl 1):S59-S64. doi: 10.1097/SAP.0000000000002098. PMID: 31513068Free PMC Article
Management of acute radiation dermatitis: A review of the literature and proposal for treatment algorithm.
Rosenthal A, Israilevich R, Moy R
J Am Acad Dermatol 2019 Aug;81(2):558-567. Epub 2019 Feb 22 doi: 10.1016/j.jaad.2019.02.047. PMID: 30802561

Recent clinical studies

Etiology

Radiation recall dermatitis induced by COVID-19 vaccination in breast cancer patients treated with postoperative radiation therapy.
Vinante L, Caroli A, Revelant A, Bertini F, Giroldi A, Marson M, Franchin G, Muraro E, Brisotto G, Steffan A, Baboci L
Breast 2022 Oct;65:49-54. Epub 2022 Jul 2 doi: 10.1016/j.breast.2022.06.008. PMID: 35816893Free PMC Article
Radiation recall with vinorelbine and cisplatin.
Zhu ZF, Fan M, Fu XL
Onkologie 2010;33(3):107-9. Epub 2010 Feb 22 doi: 10.1159/000277672. PMID: 20215801
Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy -- case report and review of literature.
Putnik K, Stadler P, Schäfer C, Koelbl O
Radiat Oncol 2006 Sep 1;1:32. doi: 10.1186/1748-717X-1-32. PMID: 16948841Free PMC Article
Radiation recall dermatitis with pemetrexed.
Hureaux J, Le Guen Y, Tuchais C, Savary L, Urban T
Lung Cancer 2005 Nov;50(2):255-8. Epub 2005 Aug 18 doi: 10.1016/j.lungcan.2005.06.006. PMID: 16111784
Characterizing the phenomenon of radiation recall dermatitis.
Camidge R, Price A
Radiother Oncol 2001 Jun;59(3):237-45. doi: 10.1016/s0167-8140(01)00328-0. PMID: 11369064

Diagnosis

Radiation recall dermatitis: A review of the literature.
Bhangoo RS, Cheng TW, Petersen MM, Thorpe CS, DeWees TA, Anderson JD, Vargas CE, Patel SH, Halyard MY, Schild SE, Wong WW
Semin Oncol 2022 Apr;49(2):152-159. Epub 2022 Apr 29 doi: 10.1053/j.seminoncol.2022.04.001. PMID: 35585004
Ceftriaxone-induced radiation recall dermatitis.
Patel NV, Samuels M, Elsayyad N
Head Neck 2020 Aug;42(8):E8-E11. Epub 2020 Apr 9 doi: 10.1002/hed.26154. PMID: 32270528
Tamoxifen-induced radiation recall dermatitis.
Bourgeois A, Grisoli SB, Soine EJ, Rosen LB
Dermatol Online J 2017 Feb 15;23(2) PMID: 28329490
Chlorambucil-Induced Radiation Recall Dermatitis.
Clark E, Boffa MJ, Magri C, Muscat V
Skinmed 2015 Jul-Aug;13(4):317-9. Epub 2015 Aug 1 PMID: 26861434
Radiation recall dermatitis.
Ristić B
Int J Dermatol 2004 Sep;43(9):627-31. doi: 10.1111/j.1365-4632.2004.02406.x. PMID: 15357739

Therapy

Radiation recall dermatitis: A review of the literature.
Bhangoo RS, Cheng TW, Petersen MM, Thorpe CS, DeWees TA, Anderson JD, Vargas CE, Patel SH, Halyard MY, Schild SE, Wong WW
Semin Oncol 2022 Apr;49(2):152-159. Epub 2022 Apr 29 doi: 10.1053/j.seminoncol.2022.04.001. PMID: 35585004
Ceftriaxone-induced radiation recall dermatitis.
Patel NV, Samuels M, Elsayyad N
Head Neck 2020 Aug;42(8):E8-E11. Epub 2020 Apr 9 doi: 10.1002/hed.26154. PMID: 32270528
Tamoxifen-induced radiation recall dermatitis.
Bourgeois A, Grisoli SB, Soine EJ, Rosen LB
Dermatol Online J 2017 Feb 15;23(2) PMID: 28329490
Chlorambucil-Induced Radiation Recall Dermatitis.
Clark E, Boffa MJ, Magri C, Muscat V
Skinmed 2015 Jul-Aug;13(4):317-9. Epub 2015 Aug 1 PMID: 26861434
Radiation recall dermatitis.
Guarneri C, Guarneri B
CMAJ 2010 Feb 23;182(3):E150. Epub 2009 Dec 21 doi: 10.1503/cmaj.090320. PMID: 20026631Free PMC Article

Prognosis

Radiation recall dermatitis induced by COVID-19 vaccination in breast cancer patients treated with postoperative radiation therapy.
Vinante L, Caroli A, Revelant A, Bertini F, Giroldi A, Marson M, Franchin G, Muraro E, Brisotto G, Steffan A, Baboci L
Breast 2022 Oct;65:49-54. Epub 2022 Jul 2 doi: 10.1016/j.breast.2022.06.008. PMID: 35816893Free PMC Article
Radiation recall dermatitis after docetaxel chemotherapy. Treatment by antioxidant ointment.
Duncker-Rohr V, Freund U, Momm F
Strahlenther Onkol 2014 May;190(5):491-3. Epub 2014 Mar 11 doi: 10.1007/s00066-014-0609-1. PMID: 24615187
Radiation recall dermatitis induced by pazopanib.
Azad A, Maddison C, Stewart J
Onkologie 2013;36(11):674-6. Epub 2013 Oct 14 doi: 10.1159/000355649. PMID: 24192773
Gemcitabine-induced radiation recall dermatitis following whole pelvic radiation therapy.
Schwartz BM, Khuntia D, Kennedy AW, Markman M
Gynecol Oncol 2003 Nov;91(2):421-2. doi: 10.1016/s0090-8258(03)00404-9. PMID: 14599876
Characterizing the phenomenon of radiation recall dermatitis.
Camidge R, Price A
Radiother Oncol 2001 Jun;59(3):237-45. doi: 10.1016/s0167-8140(01)00328-0. PMID: 11369064

Clinical prediction guides

Radiation recall dermatitis induced by COVID-19 vaccination in breast cancer patients treated with postoperative radiation therapy.
Vinante L, Caroli A, Revelant A, Bertini F, Giroldi A, Marson M, Franchin G, Muraro E, Brisotto G, Steffan A, Baboci L
Breast 2022 Oct;65:49-54. Epub 2022 Jul 2 doi: 10.1016/j.breast.2022.06.008. PMID: 35816893Free PMC Article
Vemurafenib-induced radiation recall dermatitis: case report and review of the literature.
Conen K, Mosna-Firlejczyk K, Rochlitz C, Wicki A, Itin P, Arnold AW, Gross M, Zimmermann F, Zippelius A
Dermatology 2015;230(1):1-4. Epub 2014 Nov 29 doi: 10.1159/000365918. PMID: 25472806
Radiation recall dermatitis after docetaxel chemotherapy. Treatment by antioxidant ointment.
Duncker-Rohr V, Freund U, Momm F
Strahlenther Onkol 2014 May;190(5):491-3. Epub 2014 Mar 11 doi: 10.1007/s00066-014-0609-1. PMID: 24615187
Vemurafenib and radiosensitization.
Boussemart L, Boivin C, Claveau J, Tao YG, Tomasic G, Routier E, Mateus C, Deutsch E, Robert C
JAMA Dermatol 2013 Jul;149(7):855-7. doi: 10.1001/jamadermatol.2013.4200. PMID: 23699661
Radiation recall dermatitis with pemetrexed.
Hureaux J, Le Guen Y, Tuchais C, Savary L, Urban T
Lung Cancer 2005 Nov;50(2):255-8. Epub 2005 Aug 18 doi: 10.1016/j.lungcan.2005.06.006. PMID: 16111784

Recent systematic reviews

Chemotherapy-Induced Pseudocellulitis Without Prior Radiation Exposure: A Systematic Review.
Kovacs LD, O'Donoghue M, Cogen AL
JAMA Dermatol 2023 Aug 1;159(8):870-874. doi: 10.1001/jamadermatol.2023.1735. PMID: 37379014
Recognizing cisplatin as a potential radiation recall trigger: case report and focused systematic review.
Tamaskovics B, Haussmann J, Karimi K, Daum-Marzian M, Gerber PA, Knapp F, Scheckenbach K, Bölke E, Matuschek C, Budach W
Strahlenther Onkol 2023 Jul;199(7):611-620. Epub 2023 Mar 15 doi: 10.1007/s00066-023-02059-9. PMID: 36920507Free PMC Article

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