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Reduced leukocyte alkaline phosphatase

MedGen UID:
338120
•Concept ID:
C1850780
•
Finding
Synonym: Low leukocyte alkaline phosphatase
 
HPO: HP:0004852

Definition

Decreased alkaline phosphatase measured within leukocytes. [from HPO]

Conditions with this feature

Chronic myelogenous leukemia, BCR-ABL1 positive
MedGen UID:
75993
•Concept ID:
C0279543
•
Neoplastic Process
A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate.
See: Condition Record
Myeloproliferative disease, autosomal recessive
MedGen UID:
338119
•Concept ID:
C1850779
•
Disease or Syndrome
See: Condition Record
Chronic myelogenous leukemia, BCR-ABL1 positive
Myeloproliferative disease, autosomal recessive

Professional guidelines

PubMed

Hydroxyurea in the treatment of polycythemia vera: a prospective study of 100 patients over a 20-year period.
West WO
South Med J 1987 Mar;80(3):323-7. doi: 10.1097/00007611-198703000-00012. PMID: 3824016

Recent clinical studies

Etiology

Association between Plasma HLA-DR+ Placental Vesicles and Preeclampsia: A Pilot Longitudinal Cohort Study.
Onori M, Franco R, Lucchetti D, Tartaglia S, Buongiorno S, Beneduce G, Sannino F, Baroni S, Urbani A, Lanzone A, Scambia G, Di Simone N, Tersigni C
Cells 2024 Jan 20;13(2) doi: 10.3390/cells13020196. PMID: 38275821Free PMC Article
Association between dietary antioxidant levels and chronic obstructive pulmonary disease: a mediation analysis of inflammatory factors.
Liu Z, Li J, Chen T, Zhao X, Chen Q, Xiao L, Peng Z, Zhang H
Front Immunol 2023;14:1310399. Epub 2024 Jan 8 doi: 10.3389/fimmu.2023.1310399. PMID: 38259449Free PMC Article
Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms.
Reeves BN, Beckman JD
Curr Hematol Malig Rep 2021 Jun;16(3):304-313. Epub 2021 Apr 19 doi: 10.1007/s11899-021-00630-8. PMID: 33876389Free PMC Article
Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure.
Engelmann C, Adebayo D, Oria M, De Chiara F, Novelli S, Habtesion A, Davies N, Andreola F, Jalan R
Sci Rep 2020 Jan 15;10(1):389. doi: 10.1038/s41598-019-57284-z. PMID: 31942020Free PMC Article
Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation.
Huizinga R, Kreft KL, Onderwater S, Boonstra JG, Brands R, Hintzen RQ, Laman JD
J Neuroinflammation 2012 Dec 11;9:266. doi: 10.1186/1742-2094-9-266. PMID: 23231745Free PMC Article

Diagnosis

Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms.
Reeves BN, Beckman JD
Curr Hematol Malig Rep 2021 Jun;16(3):304-313. Epub 2021 Apr 19 doi: 10.1007/s11899-021-00630-8. PMID: 33876389Free PMC Article
Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure.
Engelmann C, Adebayo D, Oria M, De Chiara F, Novelli S, Habtesion A, Davies N, Andreola F, Jalan R
Sci Rep 2020 Jan 15;10(1):389. doi: 10.1038/s41598-019-57284-z. PMID: 31942020Free PMC Article
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
Herat L, Rudnicka C, Okada Y, Mochizuki S, Schlaich M, Matthews V
Int J Mol Sci 2017 Apr 21;18(4) doi: 10.3390/ijms18040884. PMID: 28430139Free PMC Article
UK NEQAS for leucocyte immunophenotyping: the first 10 years.
Reilly JT, Barnett D
J Clin Pathol 2001 Jul;54(7):508-11. doi: 10.1136/jcp.54.7.508. PMID: 11429420Free PMC Article
Polycythemia vera.
Murphy S
Dis Mon 1992 Mar;38(3):153-212. doi: 10.1016/0011-5029(92)90002-7. PMID: 1587207

Therapy

Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms.
Reeves BN, Beckman JD
Curr Hematol Malig Rep 2021 Jun;16(3):304-313. Epub 2021 Apr 19 doi: 10.1007/s11899-021-00630-8. PMID: 33876389Free PMC Article
Reduced glutathione ameliorates liver function, oxidative stress and inflammation after interventional therapy for hepatocellular carcinoma.
Ke Y, Wu T, Lei X, Zhang C, Zhou J, Li J, Zhang H, Chen X, Wang J, Wang L
J BUON 2020 May-Jun;25(3):1361-1367. PMID: 32862577
Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure.
Engelmann C, Adebayo D, Oria M, De Chiara F, Novelli S, Habtesion A, Davies N, Andreola F, Jalan R
Sci Rep 2020 Jan 15;10(1):389. doi: 10.1038/s41598-019-57284-z. PMID: 31942020Free PMC Article
A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma.
Fricker M, Gibson PG, Powell H, Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Baines KJ
J Allergy Clin Immunol 2019 Jul;144(1):51-60.e11. Epub 2019 Jan 22 doi: 10.1016/j.jaci.2018.12.1020. PMID: 30682452
Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation.
Huizinga R, Kreft KL, Onderwater S, Boonstra JG, Brands R, Hintzen RQ, Laman JD
J Neuroinflammation 2012 Dec 11;9:266. doi: 10.1186/1742-2094-9-266. PMID: 23231745Free PMC Article

Prognosis

Baseline liver function tests and full blood count indices and their association with progression of chronic kidney disease and renal outcomes in Aboriginal and Torres Strait Islander people: the eGFR follow- up study.
Majoni SW, Barzi F, Hoy W, MacIsaac RJ, Cass A, Maple-Brown L, Hughes JT
BMC Nephrol 2020 Dec 1;21(1):523. doi: 10.1186/s12882-020-02185-x. PMID: 33261565Free PMC Article
Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis.
Deng C, Li W, Fei Y, Wang L, Chen Y, Zeng X, Zhang F, Li Y
Front Immunol 2020;11:1619. Epub 2020 Jul 24 doi: 10.3389/fimmu.2020.01619. PMID: 32793241Free PMC Article
Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice.
Bella LM, Fieri I, Tessaro FHG, Nolasco EL, Nunes FPB, Ferreira SS, Azevedo CB, Martins JO
Biomed Res Int 2017;2017:7651815. Epub 2017 Apr 19 doi: 10.1155/2017/7651815. PMID: 28503574Free PMC Article
Clinical significance of CYP2C9-status guided valproic acid therapy in children.
Bűdi T, Tóth K, Nagy A, Szever Z, Kiss Á, Temesvári M, Háfra E, Garami M, Tapodi A, Monostory K
Epilepsia 2015 Jun;56(6):849-55. Epub 2015 May 13 doi: 10.1111/epi.13011. PMID: 25967074
UK NEQAS for leucocyte immunophenotyping: the first 10 years.
Reilly JT, Barnett D
J Clin Pathol 2001 Jul;54(7):508-11. doi: 10.1136/jcp.54.7.508. PMID: 11429420Free PMC Article

Clinical prediction guides

Association between Plasma HLA-DR+ Placental Vesicles and Preeclampsia: A Pilot Longitudinal Cohort Study.
Onori M, Franco R, Lucchetti D, Tartaglia S, Buongiorno S, Beneduce G, Sannino F, Baroni S, Urbani A, Lanzone A, Scambia G, Di Simone N, Tersigni C
Cells 2024 Jan 20;13(2) doi: 10.3390/cells13020196. PMID: 38275821Free PMC Article
Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2.
Homen-Fernandez JR, Valls A, García A, Cabello N, Ortega I, Orviz E, Foncubierta C, Martínez M, Estrada V
Front Immunol 2023;14:1267991. Epub 2023 Oct 16 doi: 10.3389/fimmu.2023.1267991. PMID: 37908351Free PMC Article
Biofabrication of anin-vitrobone model for Gaucher disease.
Banerjee D, Ivanova MM, Celik N, Kim MH, Derman ID, Limgala RP, Ozbolat IT, Goker-Alpan O
Biofabrication 2023 Sep 22;15(4) doi: 10.1088/1758-5090/acf95a. PMID: 37703870Free PMC Article
The Inhibition of Osteoblast Viability by Monosodium Urate Crystal-Stimulated Neutrophil-Derived Exosomes.
Jia E, Zhu H, Geng H, Zhong L, Qiu X, Xie J, Xiao Y, Jiang Y, Xiao M, Zhang Y, Wei J, Tang D, Zhang J
Front Immunol 2022;13:809586. Epub 2022 May 17 doi: 10.3389/fimmu.2022.809586. PMID: 35655781Free PMC Article
Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis.
Preuße C, Paesler B, Nelke C, Cengiz D, Müntefering T, Roos A, Amelin D, Allenbach Y, Uruha A, Dittmayer C, Hentschel A, Pawlitzki M, Hoffmann S, Timm S, Louis SL, Dengler NF, Wiendl H, Lünemann JD, Sickmann A, Hervier B, Meuth SG, Schneider U, Schänzer A, Krause S, Tomaras S, Feist E, Hasseli R, Goebel HH, Gallay L, Streichenberger N, Benveniste O, Stenzel W, Ruck T
Acta Neuropathol 2022 Aug;144(2):353-372. Epub 2022 May 25 doi: 10.1007/s00401-022-02438-z. PMID: 35612662Free PMC Article

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