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Abnormalities, Drug-Induced

MedGen UID:
35
•Concept ID:
C0000771
•
Congenital Abnormality
Synonyms: Abnormalities, Drug Induced; Abnormality, Drug-Induced; Drug Induced Abnormalities; Drug-Induced Abnormalities; Drug-Induced Abnormality

Definition

Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormalities, Drug-Induced

Professional guidelines

PubMed

ECCO Topical Review on Clinicopathological Spectrum and Differential Diagnosis of Inflammatory Bowel Disease.
Feakins R, Torres J, Borralho-Nunes P, Burisch J, Cúrdia Gonçalves T, De Ridder L, Driessen A, Lobatón T, Menchén L, Mookhoek A, Noor N, Svrcek M, Villanacci V, Zidar N, Tripathi M
J Crohns Colitis 2022 Mar 14;16(3):343-368. doi: 10.1093/ecco-jcc/jjab141. PMID: 34346490
The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists.
Yonkers KA, Wisner KL, Stewart DE, Oberlander TF, Dell DL, Stotland N, Ramin S, Chaudron L, Lockwood C
Gen Hosp Psychiatry 2009 Sep-Oct;31(5):403-13. doi: 10.1016/j.genhosppsych.2009.04.003. PMID: 19703633Free PMC Article
The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists.
Yonkers KA, Wisner KL, Stewart DE, Oberlander TF, Dell DL, Stotland N, Ramin S, Chaudron L, Lockwood C
Obstet Gynecol 2009 Sep;114(3):703-713. doi: 10.1097/AOG.0b013e3181ba0632. PMID: 19701065Free PMC Article

Recent clinical studies

Etiology

Teratogenicity of antiepileptic drugs.
Tomson T, Battino D, Perucca E
Curr Opin Neurol 2019 Apr;32(2):246-252. doi: 10.1097/WCO.0000000000000659. PMID: 30664067
Pregnancy, epilepsy, and anticonvulsants.
Steinhoff BJ
Dialogues Clin Neurosci 2008;10(1):63-75. doi: 10.31887/DCNS.2008.10.1/bjsteinhoff. PMID: 18472485Free PMC Article
Epilepsy in pregnancy.
Tomson T, Hiilesmaa V
BMJ 2007 Oct 13;335(7623):769-73. doi: 10.1136/bmj.39266.473113.BE. PMID: 17932208Free PMC Article
Epilepsy and pregnancy.
Oguni M, Osawa M
Epilepsia 2004;45 Suppl 8:37-41. doi: 10.1111/j.0013-9580.2004.458008.x. PMID: 15610193
Workplace reproductive problems.
Frazier LM
Prim Care 2000 Dec;27(4):1039-56. doi: 10.1016/s0095-4543(05)70188-3. PMID: 11072298

Diagnosis

Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations.
Huybrechts KF, Hernández-Díaz S, Patorno E, Desai RJ, Mogun H, Dejene SZ, Cohen JM, Panchaud A, Cohen L, Bateman BT
JAMA Psychiatry 2016 Sep 1;73(9):938-46. doi: 10.1001/jamapsychiatry.2016.1520. PMID: 27540849Free PMC Article
Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation.
Butler DC, Heller MM, Murase JE
J Am Acad Dermatol 2014 Mar;70(3):417.e1-10; quiz 427. doi: 10.1016/j.jaad.2013.09.009. PMID: 24528912
Ovulatory dysfunction.
Lunenfeld B, Azem F
Curr Opin Obstet Gynecol 1991 Apr;3(2):176-81. PMID: 1912348
Leukemia in pregnancy.
McLain CR Jr
Clin Obstet Gynecol 1974 Dec;17(4):185-94. doi: 10.1097/00003081-197412000-00013. PMID: 4615858
Colchicine.
Wallace SL
Semin Arthritis Rheum 1974 Summer;3(4):369-81. doi: 10.1016/0049-0172(74)90006-7. PMID: 4598037

Therapy

Daclizumab in multiple sclerosis.
Perez-Miralles FC
Rev Neurol 2018 Apr 16;66(8):271-282. PMID: 29645071
Epilepsy in pregnancy.
Kinney MO, Morrow J
BMJ 2016 Jun 2;353:i2880. doi: 10.1136/bmj.i2880. PMID: 27255543
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
Circulation 2016 Mar 15;133(11):1115-24. doi: 10.1161/CIRCULATIONAHA.115.018622. PMID: 26976916Free PMC Article
Isotretinoin and teratogenicity.
Strauss JS, Cunningham WJ, Leyden JJ, Pochi PE, Shalita AR
J Am Acad Dermatol 1988 Aug;19(2 Pt 1):353-4. doi: 10.1016/s0190-9622(88)80249-4. PMID: 3170797
Valproate and malformations.
Lancet 1982 Dec 11;2(8311):1313-4. PMID: 6128602

Prognosis

Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations.
Huybrechts KF, Hernandez-Diaz S, Straub L, Gray KJ, Zhu Y, Mogun H, Bateman BT
JAMA 2020 Jan 28;323(4):372-374. doi: 10.1001/jama.2019.18587. PMID: 31730152Free PMC Article
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F; EURAP Study Group
Lancet Neurol 2018 Jun;17(6):530-538. Epub 2018 Apr 18 doi: 10.1016/S1474-4422(18)30107-8. PMID: 29680205
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
Hubers SA, Brown NJ
Circulation 2016 Mar 15;133(11):1115-24. doi: 10.1161/CIRCULATIONAHA.115.018622. PMID: 26976916Free PMC Article
Retinoids as teratogens.
Soprano DR, Soprano KJ
Annu Rev Nutr 1995;15:111-32. doi: 10.1146/annurev.nu.15.070195.000551. PMID: 8527214
CANADIAN THALIDOMIDE EXPERIENCE.
WEBB JF
Can Med Assoc J 1963 Nov 9;89(19):987-92. PMID: 14076167Free PMC Article

Clinical prediction guides

Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US.
Huybrechts KF, Straub L, Karlsson P, Pazzagli L, Furu K, Gissler M, Hernandez-Diaz S, Nørgaard M, Zoega H, Bateman BT, Cesta CE, Cohen JM, Leinonen MK, Reutfors J, Selmer RM, Suarez EA, Ulrichsen SP, Kieler H
JAMA Psychiatry 2023 Feb 1;80(2):156-166. doi: 10.1001/jamapsychiatry.2022.4109. PMID: 36477338Free PMC Article
Thalidomide and neurotrophism.
Soper JR, Bonar SF, O'Sullivan DJ, McCredie J, Willert HG
Skeletal Radiol 2019 Apr;48(4):517-525. Epub 2018 Oct 19 doi: 10.1007/s00256-018-3086-2. PMID: 30341712Free PMC Article
Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births.
Gao SY, Wu QJ, Sun C, Zhang TN, Shen ZQ, Liu CX, Gong TT, Xu X, Ji C, Huang DH, Chang Q, Zhao YH
BMC Med 2018 Nov 12;16(1):205. doi: 10.1186/s12916-018-1193-5. PMID: 30415641Free PMC Article
Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations.
Huybrechts KF, Hernández-Díaz S, Patorno E, Desai RJ, Mogun H, Dejene SZ, Cohen JM, Panchaud A, Cohen L, Bateman BT
JAMA Psychiatry 2016 Sep 1;73(9):938-46. doi: 10.1001/jamapsychiatry.2016.1520. PMID: 27540849Free PMC Article
Teratogenic potential of cocaine.
Buehler BA, Conover B, Andres RL
Semin Perinatol 1996 Apr;20(2):93-8. doi: 10.1016/s0146-0005(96)80076-0. PMID: 8857694

Recent systematic reviews

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births.
Gao SY, Wu QJ, Sun C, Zhang TN, Shen ZQ, Liu CX, Gong TT, Xu X, Ji C, Huang DH, Chang Q, Zhao YH
BMC Med 2018 Nov 12;16(1):205. doi: 10.1186/s12916-018-1193-5. PMID: 30415641Free PMC Article
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes.
Veroniki AA, Cogo E, Rios P, Straus SE, Finkelstein Y, Kealey R, Reynen E, Soobiah C, Thavorn K, Hutton B, Hemmelgarn BR, Yazdi F, D'Souza J, MacDonald H, Tricco AC
BMC Med 2017 May 5;15(1):95. doi: 10.1186/s12916-017-0845-1. PMID: 28472982Free PMC Article
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
Weston J, Bromley R, Jackson CF, Adab N, Clayton-Smith J, Greenhalgh J, Hounsome J, McKay AJ, Tudur Smith C, Marson AG
Cochrane Database Syst Rev 2016 Nov 7;11(11):CD010224. doi: 10.1002/14651858.CD010224.pub2. PMID: 27819746Free PMC Article
The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation.
Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, da Silva J, Nelson-Piercy C, Cetin I, Costedoat-Chalumeau N, Dolhain R, Förger F, Khamashta M, Ruiz-Irastorza G, Zink A, Vencovsky J, Cutolo M, Caeyers N, Zumbühl C, Østensen M
Ann Rheum Dis 2016 May;75(5):795-810. Epub 2016 Feb 17 doi: 10.1136/annrheumdis-2015-208840. PMID: 26888948

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