U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreatic carcinoma with mixed differentiation

MedGen UID:
353935
•Concept ID:
C1709050
•
Neoplastic Process
Synonyms: MiNEN of pancreas; Mixed Exocrine-Endocrine Carcinoma of the Pancreas; mixed exocrine-endocrine carcinoma of the pancreas; Mixed neuroendocrine and non-neuroendocrine neoplasm of pancreas; mixed neuroendocrine-nonneuroendocrine neoplasm of pancreas; Pancreatic Carcinoma with Mixed Differentiation; pancreatic carcinoma with mixed differentiation; Pancreatic MiNEN; pancreatic MiNEN; Pancreatic Mixed Adenoneuroendocrine Carcinoma; Pancreatic Mixed Neuroendocrine-Non-Neuroendocrine Carcinoma; Pancreatic mixed neuroendocrine-nonneuroendocrine neoplasm; pancreatic mixed neuroendocrine-nonneuroendocrine neoplasm
 
Monarch Initiative: MONDO:0044727
Orphanet: ORPHA506112

Definition

A rare neuroendocrine neoplasm of pancreas characterized by morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting at least 30% of the tumor volume. Based on histopathology, mixed ductal- and mixed acinar-neuroendocrine carcinomas are distinguished. Patients usually present with unspecific symptoms related to tumor growth and/or metastasis, although occurrence of Zollinger-Ellison syndrome has been reported. Resectability of the tumor is the most important prognostic factor. [from ORDO]

Professional guidelines

PubMed

Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H
Cells 2023 Feb 11;12(4) doi: 10.3390/cells12040587. PMID: 36831254Free PMC Article
An Update on the Management of Mixed Neuroendocrine-Non-neuroendocrine Neoplasms (MiNEN).
Jacob A, Raj R, Allison DB, Soares HP, Chauhan A
Curr Treat Options Oncol 2022 May;23(5):721-735. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00968-y. PMID: 35347561
Current status on the diagnosis and management of pancreatic cysts in the Asia-Pacific region: role of endoscopic ultrasound.
Lim LG, Itoi T, Lim WC, Mesenas SJ, Seo DW, Tan J, Wang HP, Akaraviputh T, Lakhtakia S, Omar S, Rantachu T, Sachitanandan S, Yasuda K, Varadarajulu S, Wong J, Dhir V, Ho KY; Asian Consortium of EUS
J Gastroenterol Hepatol 2011 Dec;26(12):1702-8. doi: 10.1111/j.1440-1746.2011.06884.x. PMID: 21871024

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the pancreas: diagnosis and pitfalls.
Konukiewitz B, Jesinghaus M, Kasajima A, Klöppel G
Virchows Arch 2022 Feb;480(2):247-257. Epub 2021 Oct 13 doi: 10.1007/s00428-021-03211-5. PMID: 34647171Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Serous pancreatic neoplasia, data and review.
Dietrich CF, Dong Y, Jenssen C, Ciaravino V, Hocke M, Wang WP, Burmester E, Moeller K, Atkinson NS, Capelli P, D'Onofrio M
World J Gastroenterol 2017 Aug 14;23(30):5567-5578. doi: 10.3748/wjg.v23.i30.5567. PMID: 28852316Free PMC Article

Diagnosis

Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms.
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Neuroendocrine neoplasms of the pancreas: diagnosis and pitfalls.
Konukiewitz B, Jesinghaus M, Kasajima A, Klöppel G
Virchows Arch 2022 Feb;480(2):247-257. Epub 2021 Oct 13 doi: 10.1007/s00428-021-03211-5. PMID: 34647171Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Malignant epithelial/exocrine tumors of the pancreas.
Luchini C, Grillo F, Fassan M, Vanoli A, Capelli P, Paolino G, Ingravallo G, Renzulli G, Doglioni C, D'Amuri A, Mattiolo P, Pecori S, Parente P, Florena AM, Zamboni G, Scarpa A
Pathologica 2020 Sep;112(3):210-226. doi: 10.32074/1591-951X-167. PMID: 33179623Free PMC Article
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article

Therapy

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design.
Groarke JD, Crawford J, Collins SM, Lubaczewski SL, Breen DM, Harrington MA, Jacobs I, Qiu R, Revkin J, Rossulek MI, Saxena AR
J Cachexia Sarcopenia Muscle 2024 Jun;15(3):1054-1061. Epub 2024 Mar 18 doi: 10.1002/jcsm.13435. PMID: 38500292Free PMC Article
Roles and Regulations of TET Enzymes in Solid Tumors.
Bray JK, Dawlaty MM, Verma A, Maitra A
Trends Cancer 2021 Jul;7(7):635-646. Epub 2021 Jan 16 doi: 10.1016/j.trecan.2020.12.011. PMID: 33468438
Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.
Li L, Bi Z, Wadgaonkar P, Lu Y, Zhang Q, Fu Y, Thakur C, Wang L, Chen F
Semin Cancer Biol 2019 Aug;57:10-18. Epub 2019 Apr 19 doi: 10.1016/j.semcancer.2019.04.003. PMID: 31009762Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Serous pancreatic neoplasia, data and review.
Dietrich CF, Dong Y, Jenssen C, Ciaravino V, Hocke M, Wang WP, Burmester E, Moeller K, Atkinson NS, Capelli P, D'Onofrio M
World J Gastroenterol 2017 Aug 14;23(30):5567-5578. doi: 10.3748/wjg.v23.i30.5567. PMID: 28852316Free PMC Article

Prognosis

Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.
Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G
Cancer Cell 2024 Apr 8;42(4):662-681.e10. Epub 2024 Mar 21 doi: 10.1016/j.ccell.2024.02.017. PMID: 38518775
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Clinical prediction guides

Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.
Di Chiaro P, Nacci L, Arco F, Brandini S, Polletti S, Palamidessi A, Donati B, Soriani C, Gualdrini F, Frigè G, Mazzarella L, Ciarrocchi A, Zerbi A, Spaggiari P, Scita G, Rodighiero S, Barozzi I, Diaferia GR, Natoli G
Cancer Cell 2024 Apr 8;42(4):662-681.e10. Epub 2024 Mar 21 doi: 10.1016/j.ccell.2024.02.017. PMID: 38518775
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Intraductal papillary mucinous neoplasms of the pancreas--a surgical disease.
Werner J, Fritz S, Büchler MW
Nat Rev Gastroenterol Hepatol 2012 Mar 6;9(5):253-9. doi: 10.1038/nrgastro.2012.31. PMID: 22392299

Recent systematic reviews

Synchronous or metachronous presentation of pancreatic neuroendocrine tumor versus secondary lesion to pancreas in patients affected by renal cell carcinoma. Systematic review.
Persano I, Parlagreco E, La Salvia A, Audisio M, Volante M, Buttigliero C, Scagliotti GV, Brizzi MP
Semin Oncol 2022 Dec;49(6):476-481. Epub 2023 Feb 2 doi: 10.1053/j.seminoncol.2023.01.007. PMID: 36759234
Escalated-dose somatostatin analogues for antiproliferative effect in GEPNETS: a systematic review.
Chan DL, Ferone D, Albertelli M, Pavlakis N, Segelov E, Singh S
Endocrine 2017 Sep;57(3):366-375. Epub 2017 Jul 19 doi: 10.1007/s12020-017-1360-z. PMID: 28726183
Unraveling molecular pathways of poorly differentiated neuroendocrine carcinomas of the gastroenteropancreatic system: A systematic review.
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...