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Antiviral state repressor, regulator of(AVRR)

MedGen UID:
354815
•Concept ID:
C1862714
•
Finding
Synonym: AVRR
 
OMIM®: 107440

Professional guidelines

PubMed

Peripheral Blood Mononuclear Cell Gene Expression Remains Broadly Altered Years after Successful Interferon-Based Hepatitis C Virus Treatment.
Waldron PR, Holodniy M
J Immunol Res 2015;2015:958231. Epub 2015 Oct 19 doi: 10.1155/2015/958231. PMID: 26568966Free PMC Article
Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells.
Cetinkaya C, Hultquist A, Su Y, Wu S, Bahram F, Påhlman S, Guzhova I, Larsson LG
Mol Cancer Ther 2007 Oct;6(10):2634-41. doi: 10.1158/1535-7163.MCT-06-0492. PMID: 17938259
Activation of the jun-D gene during treatment of human myeloid leukemia cells with 1-beta-D-arabinofuranosylcytosine.
Kharbanda S, Huberman E, Kufe D
Biochem Pharmacol 1993 May 25;45(10):2055-61. doi: 10.1016/0006-2952(93)90016-p. PMID: 8512587

Recent clinical studies

Etiology

Identification of Amino Acid Residues Required for Inhibition of Host Gene Expression by Influenza Virus A/Viet Nam/1203/2004 H5N1 PA-X.
Chiem K, López-García D, Ortego J, Martinez-Sobrido L, DeDiego ML, Nogales A
J Virol 2022 Mar 9;96(5):e0040821. Epub 2021 Apr 14 doi: 10.1128/JVI.00408-21. PMID: 33853954Free PMC Article
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, Tian X, Gao Q, Ma X, Yang J, Wu J, Tan S, Xu H, Tang X, Wang Y, Yu Z, Han H, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Fan W, Jin Z, Cao C, Yu M, Xie W, Huang Z, Hu Z, You Z
Antiviral Res 2020 Jun;178:104794. Epub 2020 Apr 14 doi: 10.1016/j.antiviral.2020.104794. PMID: 32298665
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.
Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS
mBio 2014 Dec 23;5(6) doi: 10.1128/mBio.02234-14. PMID: 25538195Free PMC Article
TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.
Singh R, Patel V, Mureithi MW, Naranbhai V, Ramsuran D, Tulsi S, Hiramen K, Werner L, Mlisana K, Altfeld M, Luban J, Kasprowicz V, Dheda K, Abdool Karim SS, Ndung'u T
J Virol 2014 Apr;88(8):4291-303. Epub 2014 Jan 29 doi: 10.1128/JVI.03603-13. PMID: 24478420Free PMC Article
Negative regulation of cytoplasmic RNA-mediated antiviral signaling.
Komuro A, Bamming D, Horvath CM
Cytokine 2008 Sep;43(3):350-8. Epub 2008 Aug 13 doi: 10.1016/j.cyto.2008.07.011. PMID: 18703349Free PMC Article

Diagnosis

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
Marzio A, Kurz E, Sahni JM, Di Feo G, Puccini J, Jiang S, Hirsch CA, Arbini AA, Wu WL, Pass HI, Bar-Sagi D, Papagiannakopoulos T, Pagano M
Cell 2022 Jan 6;185(1):169-183.e19. Epub 2021 Dec 27 doi: 10.1016/j.cell.2021.12.005. PMID: 34963055Free PMC Article
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.
Kawabata KC, Zong H, Meydan C, Wyman S, Wouters BJ, Sugita M, Goswami S, Albert M, Yip W, Roboz GJ, Chen Z, Delwel R, Carroll M, Mason CE, Melnick A, Guzman ML
Blood 2021 Feb 11;137(6):812-825. doi: 10.1182/blood.2019001745. PMID: 32911532Free PMC Article
PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H
J Virol 2020 May 4;94(10) doi: 10.1128/JVI.01923-19. PMID: 32161174Free PMC Article
Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter.
Wang X, Liu H, Ge H, Ajiro M, Sharma NR, Meyers C, Morozov P, Tuschl T, Klar A, Court D, Zheng ZM
mBio 2017 May 30;8(3) doi: 10.1128/mBio.00713-17. PMID: 28559488Free PMC Article
LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.
Bentz GL, Moss CR 2nd, Whitehurst CB, Moody CA, Pagano JS
J Virol 2015 Aug;89(15):7465-77. Epub 2015 May 6 doi: 10.1128/JVI.00711-15. PMID: 25948750Free PMC Article

Therapy

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C
Cell 2021 Jan 21;184(2):352-369.e23. Epub 2020 Dec 23 doi: 10.1016/j.cell.2020.11.042. PMID: 33357448Free PMC Article
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.
Kawabata KC, Zong H, Meydan C, Wyman S, Wouters BJ, Sugita M, Goswami S, Albert M, Yip W, Roboz GJ, Chen Z, Delwel R, Carroll M, Mason CE, Melnick A, Guzman ML
Blood 2021 Feb 11;137(6):812-825. doi: 10.1182/blood.2019001745. PMID: 32911532Free PMC Article
Reduction of Global H3K27me(3) Enhances HER2/ErbB2 Targeted Therapy.
Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ
Cell Rep 2019 Oct 8;29(2):249-257.e8. doi: 10.1016/j.celrep.2019.08.105. PMID: 31597089
Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC
Oncogene 2017 Oct 26;36(43):6006-6019. Epub 2017 Jul 3 doi: 10.1038/onc.2017.205. PMID: 28671669Free PMC Article
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL
J Clin Invest 2014 Jan;124(1):222-36. Epub 2013 Dec 16 doi: 10.1172/JCI66005. PMID: 24334453Free PMC Article

Prognosis

Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance.
James JL, Taylor BC, Axelrod ML, Sun X, Guerin LN, Gonzalez-Ericsson PI, Wang Y, Sanchez V, Fahey CC, Sanders ME, Xu Y, Hodges E, Johnson DB, Balko JM
J Immunother Cancer 2023 Nov 20;11(11) doi: 10.1136/jitc-2023-007736. PMID: 38315170Free PMC Article
The role of tryptophan in Chlamydia trachomatis persistence.
Wang L, Hou Y, Yuan H, Chen H
Front Cell Infect Microbiol 2022;12:931653. Epub 2022 Aug 2 doi: 10.3389/fcimb.2022.931653. PMID: 35982780Free PMC Article
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.
Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG
Cancer Cell 2020 Apr 13;37(4):599-617.e7. Epub 2020 Apr 2 doi: 10.1016/j.ccell.2020.03.005. PMID: 32243837Free PMC Article
Role of ND10 nuclear bodies in the chromatin repression of HSV-1.
Gu H, Zheng Y
Virol J 2016 Apr 5;13:62. doi: 10.1186/s12985-016-0516-4. PMID: 27048561Free PMC Article
PKR, apoptosis and cancer.
Jagus R, Joshi B, Barber GN
Int J Biochem Cell Biol 1999 Jan;31(1):123-38. doi: 10.1016/s1357-2725(98)00136-8. PMID: 10216948

Clinical prediction guides

Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance.
James JL, Taylor BC, Axelrod ML, Sun X, Guerin LN, Gonzalez-Ericsson PI, Wang Y, Sanchez V, Fahey CC, Sanders ME, Xu Y, Hodges E, Johnson DB, Balko JM
J Immunother Cancer 2023 Nov 20;11(11) doi: 10.1136/jitc-2023-007736. PMID: 38315170Free PMC Article
Rb-E2F-HDAC Repressor Complexes Control Interferon-Induced Repression of Adenovirus To Promote Persistent Infection.
Snaider S, Zheng Y, Hearing P
J Virol 2022 Jun 8;96(11):e0044222. Epub 2022 May 12 doi: 10.1128/jvi.00442-22. PMID: 35546119Free PMC Article
Role of ND10 nuclear bodies in the chromatin repression of HSV-1.
Gu H, Zheng Y
Virol J 2016 Apr 5;13:62. doi: 10.1186/s12985-016-0516-4. PMID: 27048561Free PMC Article
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.
Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS
mBio 2014 Dec 23;5(6) doi: 10.1128/mBio.02234-14. PMID: 25538195Free PMC Article
Identification and characterization of a novel repressor of beta-interferon gene expression.
Keller AD, Maniatis T
Genes Dev 1991 May;5(5):868-79. doi: 10.1101/gad.5.5.868. PMID: 1851123

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