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Flexural Skin Nevus

MedGen UID:
363797
•Concept ID:
C1880790
•
Neoplastic Process
Synonym: Nevus of Flexural Skin

Definition

A benign nevus occurring in the flexural skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlexural Skin Nevus

Professional guidelines

PubMed

A Single-Institution Cohort Study With Nevi of Special Site: Recurrence, Progression to Melanoma, and Patterns of Management.
Elkeeb DM, Hopkins ZH, Bolender CM, Moreno C, Florell SR, Bowen AR, Vitale P, Zussman J, Duffy K, Grossman D, Secrest AM, Wada DA
Am J Dermatopathol 2023 Jan 1;45(1):28-39. Epub 2022 Nov 2 doi: 10.1097/DAD.0000000000002134. PMID: 36484604

Recent clinical studies

Etiology

Incidental Melanocytic Nevi in Hemorrhoidectomy Specimens.
Val-Bernal JF, Mayorga M, Val D
Am J Dermatopathol 2016 Apr;38(4):278-82. doi: 10.1097/DAD.0000000000000419. PMID: 26332535
Atypical umbilical naevi: histopathological analysis of 20 cases.
Arps DP, Fullen DR, Chan MP
Histopathology 2015 Feb;66(3):363-9. Epub 2014 Dec 22 doi: 10.1111/his.12503. PMID: 25109391
Nevi of special sites.
Mason AR, Mohr MR, Koch LH, Hood AF
Clin Lab Med 2011 Jun;31(2):229-42. doi: 10.1016/j.cll.2011.03.001. PMID: 21549237
Precursors to melanoma and their mimics: nevi of special sites.
Elder DE
Mod Pathol 2006 Feb;19 Suppl 2:S4-20. doi: 10.1038/modpathol.3800515. PMID: 16446715
The characteristic histopathologic features of nevi on and around the ear.
Lazova R, Lester B, Glusac EJ, Handerson T, McNiff J
J Cutan Pathol 2005 Jan;32(1):40-4. doi: 10.1111/j.0303-6987.2005.00263.x. PMID: 15660654

Diagnosis

Reasons for rarity of anal melanocytic naevi.
Aljufairi E, Alhilli F
Australas J Dermatol 2017 Nov;58(4):308-311. Epub 2017 Feb 17 doi: 10.1111/ajd.12573. PMID: 28211047
An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots and Freckling. Part II. Other Skin Manifestations Characteristic of NF1. NF1 and Cancer.
Hernández-Martín A, Duat-Rodríguez A
Actas Dermosifiliogr 2016 Jul-Aug;107(6):465-73. Epub 2016 Mar 5 doi: 10.1016/j.ad.2016.01.009. PMID: 26956402
Incidental Melanocytic Nevi in Hemorrhoidectomy Specimens.
Val-Bernal JF, Mayorga M, Val D
Am J Dermatopathol 2016 Apr;38(4):278-82. doi: 10.1097/DAD.0000000000000419. PMID: 26332535
Nevi of special sites.
Mason AR, Mohr MR, Koch LH, Hood AF
Clin Lab Med 2011 Jun;31(2):229-42. doi: 10.1016/j.cll.2011.03.001. PMID: 21549237
Disseminated congenital comedones.
Vano-Galvan S, Hernández-Martín A, Colmenero I, Torrelo A
Pediatr Dermatol 2011 Jan-Feb;28(1):58-9. Epub 2011 Jan 25 doi: 10.1111/j.1525-1470.2010.01358.x. PMID: 21276057

Therapy

Agminated flexural melanocytic nevi: a late sequela of Langerhans cell histiocytosis?
Feldstein S, Funk T, Smith JC, Bruckner AL
Pediatr Dermatol 2015 May-Jun;32(3):e89-91. Epub 2015 Mar 17 doi: 10.1111/pde.12563. PMID: 25787131

Prognosis

A Single-Institution Cohort Study With Nevi of Special Site: Recurrence, Progression to Melanoma, and Patterns of Management.
Elkeeb DM, Hopkins ZH, Bolender CM, Moreno C, Florell SR, Bowen AR, Vitale P, Zussman J, Duffy K, Grossman D, Secrest AM, Wada DA
Am J Dermatopathol 2023 Jan 1;45(1):28-39. Epub 2022 Nov 2 doi: 10.1097/DAD.0000000000002134. PMID: 36484604
Melanocytic Nevi of Special Sites.
Ahn CS, Guerra A, Sangüeza OP
Am J Dermatopathol 2016 Dec;38(12):867-881. doi: 10.1097/DAD.0000000000000568. PMID: 27870726

Clinical prediction guides

A Single-Institution Cohort Study With Nevi of Special Site: Recurrence, Progression to Melanoma, and Patterns of Management.
Elkeeb DM, Hopkins ZH, Bolender CM, Moreno C, Florell SR, Bowen AR, Vitale P, Zussman J, Duffy K, Grossman D, Secrest AM, Wada DA
Am J Dermatopathol 2023 Jan 1;45(1):28-39. Epub 2022 Nov 2 doi: 10.1097/DAD.0000000000002134. PMID: 36484604
An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots and Freckling. Part II. Other Skin Manifestations Characteristic of NF1. NF1 and Cancer.
Hernández-Martín A, Duat-Rodríguez A
Actas Dermosifiliogr 2016 Jul-Aug;107(6):465-73. Epub 2016 Mar 5 doi: 10.1016/j.ad.2016.01.009. PMID: 26956402
Atypical umbilical naevi: histopathological analysis of 20 cases.
Arps DP, Fullen DR, Chan MP
Histopathology 2015 Feb;66(3):363-9. Epub 2014 Dec 22 doi: 10.1111/his.12503. PMID: 25109391
Morphologic and immunohistochemical features of breast nevi.
Nicolau AA, Aşchie M
Rom J Morphol Embryol 2013;54(2):371-5. PMID: 23771084
Melanocytic nevi of the breast: a histologic case-control study.
Rongioletti F, Urso C, Batolo D, Chimenti S, Fanti PA, Filotico R, Gianotti R, Innocenzi D, Lentini M, Tomasini C, Pippione M, Rebora A
J Cutan Pathol 2004 Feb;31(2):137-40. doi: 10.1111/j.0303-6987.2004.00159.x. PMID: 14690457

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