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Salivary Gland Adenocarcinoma, Not Otherwise Specified

MedGen UID:
364730
•Concept ID:
C1882970
•
Neoplastic Process
Synonym: Salivary Gland Adenocarcinoma, NOS

Definition

An adenocarcinoma that arises from the salivary glands. It exhibits ductal differentiation but lacks any of the morphologic features that characterize the other well-defined primary adenocarcinomas of the salivary glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Adenocarcinoma, Not Otherwise Specified

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649
Laryngeal adenocarcinoma not otherwise specified: A population-based perspective.
Spinazzi EF, Abboud MT, Dubal PM, Verma SP, Park RC, Baredes S, Eloy JA
Laryngoscope 2017 Feb;127(2):424-429. Epub 2016 May 2 doi: 10.1002/lary.26055. PMID: 27140822
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Fonseca FP, Sena Filho M, Altemani A, Speight PM, Vargas PA
J Oral Pathol Med 2016 Feb;45(2):101-10. Epub 2015 May 20 doi: 10.1111/jop.12329. PMID: 25990369

Diagnosis

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Intrathyroid salivary adenocarcinoma not otherwise specified and parathyroid adenoma in multinodular goiter.
Gómez Rodríguez S, Guijarro de Armas G, Modroño Móstoles N, Pérez Blanco C, Martín Hita AM
Endocrinol Nutr 2016 Jun-Jul;63(6):304-6. Epub 2016 Apr 4 doi: 10.1016/j.endonu.2016.02.003. PMID: 27055746
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Fonseca FP, Sena Filho M, Altemani A, Speight PM, Vargas PA
J Oral Pathol Med 2016 Feb;45(2):101-10. Epub 2015 May 20 doi: 10.1111/jop.12329. PMID: 25990369
Salivary adenocarcinoma, not otherwise specified: a collection of orphans.
Li J, Wang BY, Nelson M, Li L, Hu Y, Urken ML, Brandwein-Gensler M
Arch Pathol Lab Med 2004 Dec;128(12):1385-94. doi: 10.5858/2004-128-1385-SANOSA. PMID: 15578883

Therapy

Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer.
Nagatani Y, Kiyota N, Imamura Y, Koyama T, Funakoshi Y, Komatsu M, Itoh T, Teshima M, Nibu KI, Sakai K, Nishio K, Shimomura M, Nakatsura T, Ikarashi D, Nakayama T, Kitano S, Minami H
Asia Pac J Clin Oncol 2024 Dec;20(6):779-788. Epub 2024 Sep 4 doi: 10.1111/ajco.14108. PMID: 39233454
Complete Response to Nivolumab of Resected Adenocarcinoma NOS With Parotid Gland Origin and Lung Metastasis.
Negishi Y, Okamoto I, Ueda Y, Sato H, Tanigawa M, Nagao T, Tsukahara K
In Vivo 2022 Nov-Dec;36(6):2840-2843. doi: 10.21873/invivo.13023. PMID: 36309400Free PMC Article
Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649
A phase II study of sorafenib in recurrent and/or metastatic salivary gland carcinomas: Translational analyses and clinical impact.
Locati LD, Perrone F, Cortelazzi B, Bergamini C, Bossi P, Civelli E, Morosi C, Lo Vullo S, Imbimbo M, Quattrone P, Dagrada GP, Granata R, Resteghini C, Mirabile A, Alfieri S, Orlandi E, Mariani L, Saibene G, Pilotti S, Licitra L
Eur J Cancer 2016 Dec;69:158-165. Epub 2016 Nov 5 doi: 10.1016/j.ejca.2016.09.022. PMID: 27821319
Cyclophosphamide, doxorubicin, and cisplatin in advanced salivary gland cancer.
Debaere D, Vander Poorten V, Nuyts S, Hauben E, Schoenaers J, Schöffski P, Clement PM
B-ENT 2011;7(1):1-6. PMID: 21563549

Prognosis

Update of newly-recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance.
Wolk RA, Cipriani NA
Histopathology 2025 Jan;86(2):183-198. Epub 2024 Aug 7 doi: 10.1111/his.15289. PMID: 39108216Free PMC Article
Molecular characterisation of tumours of the lacrimal apparatus.
Vibert R, Cyrta J, Girard E, Vacher S, Dupain C, Antonio S, Wong J, Baulande S, De Sousa JMF, Vincent-Salomon A, Masliah-Planchon J, Girard N, Le Tourneau C, Kamal M, Bièche I
Histopathology 2023 Dec;83(6):925-935. Epub 2023 Sep 14 doi: 10.1111/his.15040. PMID: 37706251
High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.
Skalova A, Leivo I, Hellquist H, Agaimy A, Simpson RHW, Stenman G, Vander Poorten V, Bishop JA, Franchi A, Hernandez-Prera JC, Slouka D, Willems SM, Olsen KD, Ferlito A
Adv Anat Pathol 2021 May 1;28(3):107-118. doi: 10.1097/PAP.0000000000000298. PMID: 33825717
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Fonseca FP, Sena Filho M, Altemani A, Speight PM, Vargas PA
J Oral Pathol Med 2016 Feb;45(2):101-10. Epub 2015 May 20 doi: 10.1111/jop.12329. PMID: 25990369

Clinical prediction guides

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Major Salivary Gland Cancer With Distant Metastasis Upon Presentation: Patterns, Outcomes, and Imaging Implications.
Benchetrit L, Mehra S, Mahajan A, Rahmati RW, Judson BL, Edwards HA
Otolaryngol Head Neck Surg 2022 Aug;167(2):305-315. Epub 2021 Nov 16 doi: 10.1177/01945998211058354. PMID: 34784258
Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
Alfieri S, Granata R, Bergamini C, Resteghini C, Bossi P, Licitra LF, Locati LD
Oral Oncol 2017 Mar;66:58-63. Epub 2017 Jan 19 doi: 10.1016/j.oraloncology.2016.12.016. PMID: 28249649
Immunohistochemical and molecular profile of salivary gland cancer in children.
Locati LD, Collini P, Imbimbo M, Barisella M, Testi A, Licitra LF, Löning T, Tiemann K, Quattrone P, Bimbatti E, Chiaravalli S, Casanova M, Tamborini E, Carta R, Gasparini P, Guzzo M, Massimino M, Ferrari A
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Jan 31 doi: 10.1002/pbc.26468. PMID: 28139061
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Fonseca FP, Sena Filho M, Altemani A, Speight PM, Vargas PA
J Oral Pathol Med 2016 Feb;45(2):101-10. Epub 2015 May 20 doi: 10.1111/jop.12329. PMID: 25990369

Recent systematic reviews

Systemic treatments in recurrent or metastatic salivary gland cancer: a systematic review.
Prost D, Iseas S, Gatineau M, Adam J, Cavalieri S, Bergamini C, Licitra L, Raymond É
ESMO Open 2024 Oct;9(10):103722. Epub 2024 Oct 4 doi: 10.1016/j.esmoop.2024.103722. PMID: 39368417Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

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