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Alzheimer disease 14(AD14)

MedGen UID:
369666
Concept ID:
C1970144
Disease or Syndrome
Synonym: Alzheimer Disease 14
 
Monarch Initiative: MONDO:0012631
OMIM®: 611154

Definition

An Alzheimer's disease that is characterized by an associated with variation in the region 1q25. [from MONDO]

Professional guidelines

PubMed

Park J, Simpson C, Patel K
Ann Pharmacother 2024 Oct;58(10):1045-1053. Epub 2023 Dec 14 doi: 10.1177/10600280231218253. PMID: 38095619

Recent clinical studies

Etiology

Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
Stefaniak O, Dobrzyńska M, Drzymała-Czyż S, Przysławski J
Nutrients 2022 Oct 30;14(21) doi: 10.3390/nu14214564. PMID: 36364826Free PMC Article
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors
Alzheimers Dement 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. PMID: 29653606Free PMC Article
Mantzavinos V, Alexiou A
Curr Alzheimer Res 2017;14(11):1149-1154. doi: 10.2174/1567205014666170203125942. PMID: 28164766Free PMC Article

Diagnosis

Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M
Int J Nanomedicine 2019;14:5541-5554. Epub 2019 Jul 19 doi: 10.2147/IJN.S200490. PMID: 31410002Free PMC Article
Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors
Alzheimers Dement 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. PMID: 29653606Free PMC Article
Mantzavinos V, Alexiou A
Curr Alzheimer Res 2017;14(11):1149-1154. doi: 10.2174/1567205014666170203125942. PMID: 28164766Free PMC Article
Alzheimer's Association
Alzheimers Dement 2016 Apr;12(4):459-509. doi: 10.1016/j.jalz.2016.03.001. PMID: 27570871

Therapy

Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
McDade E, Cummings JL, Dhadda S, Swanson CJ, Reyderman L, Kanekiyo M, Koyama A, Irizarry M, Kramer LD, Bateman RJ
Alzheimers Res Ther 2022 Dec 21;14(1):191. doi: 10.1186/s13195-022-01124-2. PMID: 36544184Free PMC Article
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Jia RX, Liang JH, Xu Y, Wang YQ
BMC Geriatr 2019 Jul 2;19(1):181. doi: 10.1186/s12877-019-1175-2. PMID: 31266451Free PMC Article
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP
Lancet Neurol 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. PMID: 25792098Free PMC Article

Prognosis

Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Cai H, Pang Y, Fu X, Ren Z, Jia L
Nat Commun 2023 Oct 24;14(1):6747. doi: 10.1038/s41467-023-42596-6. PMID: 37875471Free PMC Article
Niu H, Álvarez-Álvarez I, Guillén-Grima F, Aguinaga-Ontoso I
Neurologia 2017 Oct;32(8):523-532. Epub 2016 Apr 26 doi: 10.1016/j.nrl.2016.02.016. PMID: 27130306
Guétin S, Portet F, Picot MC, Pommié C, Messaoudi M, Djabelkir L, Olsen AL, Cano MM, Lecourt E, Touchon J
Dement Geriatr Cogn Disord 2009;28(1):36-46. Epub 2009 Jul 23 doi: 10.1159/000229024. PMID: 19628939
Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, Tang Y, Bennett DA
Arch Gen Psychiatry 2007 Feb;64(2):234-40. doi: 10.1001/archpsyc.64.2.234. PMID: 17283291

Clinical prediction guides

Park J, Simpson C, Patel K
Ann Pharmacother 2024 Oct;58(10):1045-1053. Epub 2023 Dec 14 doi: 10.1177/10600280231218253. PMID: 38095619
Cai H, Pang Y, Fu X, Ren Z, Jia L
Nat Commun 2023 Oct 24;14(1):6747. doi: 10.1038/s41467-023-42596-6. PMID: 37875471Free PMC Article
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
Honig LS, Vellas B, Woodward M, Boada M, Bullock R, Borrie M, Hager K, Andreasen N, Scarpini E, Liu-Seifert H, Case M, Dean RA, Hake A, Sundell K, Poole Hoffmann V, Carlson C, Khanna R, Mintun M, DeMattos R, Selzler KJ, Siemers E
N Engl J Med 2018 Jan 25;378(4):321-330. doi: 10.1056/NEJMoa1705971. PMID: 29365294
Bryson HM, Benfield P
Drugs Aging 1997 Mar;10(3):234-9; discussion 240-1. doi: 10.2165/00002512-199710030-00007. PMID: 9108896

Recent systematic reviews

Johansson H, Folkerts AK, Hammarström I, Kalbe E, Leavy B
J Neurol 2023 Jun;270(6):2890-2907. Epub 2023 Feb 23 doi: 10.1007/s00415-023-11610-8. PMID: 36820916Free PMC Article
Casagrande M, Forte G, Favieri F, Corbo I
Int J Environ Res Public Health 2022 Jul 11;19(14) doi: 10.3390/ijerph19148457. PMID: 35886309Free PMC Article
Naomi R, Embong H, Othman F, Ghazi HF, Maruthey N, Bahari H
Nutrients 2021 Dec 22;14(1) doi: 10.3390/nu14010020. PMID: 35010895Free PMC Article
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, Gronseth GS, Marson D, Pringsheim T, Day GS, Sager M, Stevens J, Rae-Grant A
Neurology 2018 Jan 16;90(3):126-135. Epub 2017 Dec 27 doi: 10.1212/WNL.0000000000004826. PMID: 29282327Free PMC Article

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