U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Muscle cramps, familial

MedGen UID:
371885
•Concept ID:
C1834708
•
Disease or Syndrome
Synonym: Muscle Cramps, Familial
 
Monarch Initiative: MONDO:0008022
OMIM®: 158400

Clinical features

From HPO
Muscle spasm
MedGen UID:
52431
•Concept ID:
C0037763
•
Sign or Symptom
Sudden and involuntary contractions of one or more muscles.
See: Feature record | Search on this feature
EMG: neuropathic changes
MedGen UID:
867363
•Concept ID:
C4021727
•
Finding
The presence of characteristic findings of denervation on electromyography (fibrillations, positive sharp waves, and giant motor unit potentials).
See: Feature record | Search on this feature
Elevated circulating creatine kinase concentration
MedGen UID:
69128
•Concept ID:
C0241005
•
Finding
An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood. CK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy.
See: Feature record | Search on this feature
Show allHide all

Professional guidelines

PubMed

Rehabilitation treatment of multiple sclerosis.
Duan H, Jing Y, Li Y, Lian Y, Li J, Li Z
Front Immunol 2023;14:1168821. Epub 2023 Apr 6 doi: 10.3389/fimmu.2023.1168821. PMID: 37090712Free PMC Article
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952
Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study.
von Ungern-Sternberg BS, Boda K, Chambers NA, Rebmann C, Johnson C, Sly PD, Habre W
Lancet 2010 Sep 4;376(9743):773-83. doi: 10.1016/S0140-6736(10)61193-2. PMID: 20816545

Recent clinical studies

Etiology

Urinary Catheter Management.
Fletke KJ, Jeong DH, Herrera AV
Am Fam Physician 2024 Sep;110(3):251-258. PMID: 39283848
Statin Intolerance: A Review and Update.
Tsushima Y, Hatipoglu B
Endocr Pract 2023 Jul;29(7):566-571. Epub 2023 Mar 22 doi: 10.1016/j.eprac.2023.03.004. PMID: 36958647
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952
Urinary catheter management.
Cravens DD, Zweig S
Am Fam Physician 2000 Jan 15;61(2):369-76. PMID: 10670503

Diagnosis

Urinary Catheter Management.
Fletke KJ, Jeong DH, Herrera AV
Am Fam Physician 2024 Sep;110(3):251-258. PMID: 39283848
Statin Intolerance: A Review and Update.
Tsushima Y, Hatipoglu B
Endocr Pract 2023 Jul;29(7):566-571. Epub 2023 Mar 22 doi: 10.1016/j.eprac.2023.03.004. PMID: 36958647
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952
Nocturnal leg cramps.
Allen RE, Kirby KA
Am Fam Physician 2012 Aug 15;86(4):350-5. PMID: 22963024
Post-ejaculatory pain syndrome.
Kaplan HS
J Sex Marital Ther 1993 Summer;19(2):91-103. doi: 10.1080/00926239308404893. PMID: 8336348

Therapy

Urinary Catheter Management.
Fletke KJ, Jeong DH, Herrera AV
Am Fam Physician 2024 Sep;110(3):251-258. PMID: 39283848
Does Magnesium Supplementation Treat Nocturnal Leg Cramps?
Kaufman N, White D, Bull J, Radi R, DeSanto K
Am Fam Physician 2023 Dec;108(6):619-620. PMID: 38215424
Statin Intolerance: A Review and Update.
Tsushima Y, Hatipoglu B
Endocr Pract 2023 Jul;29(7):566-571. Epub 2023 Mar 22 doi: 10.1016/j.eprac.2023.03.004. PMID: 36958647
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Nonoperative Management of Cervical Radiculopathy.
Childress MA, Becker BA
Am Fam Physician 2016 May 1;93(9):746-54. PMID: 27175952

Prognosis

Unilateral periocular spasm.
Walker C
JAAPA 2024 Feb 1;37(2):1-4. doi: 10.1097/01.JAA.0000995640.85221.b0. PMID: 38270661
Spinocerebellar ataxia type 23 (SCA23): a review.
Wu F, Wang X, Li X, Teng H, Tian T, Bai J
J Neurol 2021 Dec;268(12):4630-4645. Epub 2020 Nov 11 doi: 10.1007/s00415-020-10297-5. PMID: 33175256
Individualized prediction of late-onset dysphagia in head and neck cancer survivors.
Aylward A, Park J, Abdelaziz S, Hunt JP, Buchmann LO, Cannon RB, Rowe K, Snyder J, Deshmukh V, Newman M, Wan Y, Fraser A, Smith K, Lloyd S, Hitchcock Y, Hashibe M, Monroe MM
Head Neck 2020 Apr;42(4):708-718. Epub 2020 Feb 7 doi: 10.1002/hed.26039. PMID: 32031294
Two siblings with cortical dysplasia: Clinico-electroencephalographic features.
Fukasawa T, Kubota T, Negoro T, Maruyama S, Honda R, Saito Y, Itoh M, Kakita A, Sugai K, Otsuki T, Kato M, Natsume J, Watanabe K
Pediatr Int 2015 Jun;57(3):472-5. Epub 2015 May 27 doi: 10.1111/ped.12509. PMID: 26012518
Hereditary spastic paraplegia.
Dennis SC, Green NE
J Pediatr Orthop 1988 Jul-Aug;8(4):413-7. doi: 10.1097/01241398-198807000-00006. PMID: 3392192

Clinical prediction guides

Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures.
Glass HC, Soul JS, Chang T, Wusthoff CJ, Chu CJ, Massey SL, Abend NS, Lemmon M, Thomas C, Numis AL, Guillet R, Sturza J, McNamara NA, Rogers EE, Franck LS, McCulloch CE, Shellhaas RA
JAMA Neurol 2021 Jul 1;78(7):817-825. doi: 10.1001/jamaneurol.2021.1437. PMID: 34028496Free PMC Article
Kounis syndrome. Apropos of a clinical case.
Duarte P, Costa J, Serena C, Almeida C, Gouveia S, Lourenço C, Costa H, Paiva C
Rev Bras Ter Intensiva 2020 Mar;32(1):149-152. Epub 2020 May 8 doi: 10.5935/0103-507x.20200021. PMID: 32401974Free PMC Article
Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.
Peng JK, Hepgul N, Higginson IJ, Gao W
Palliat Med 2019 Jan;33(1):24-36. Epub 2018 Oct 22 doi: 10.1177/0269216318807051. PMID: 30345878Free PMC Article
Exercise-induced asthma.
Tan RA, Spector SL
Sports Med 1998 Jan;25(1):1-6. doi: 10.2165/00007256-199825010-00001. PMID: 9458523
Idiopathic protrusio acetabuli in juveniles.
Shore A, Macauley D, Ansell BM
Rheumatol Rehabil 1981 Feb 1;20(1):1-10. doi: 10.1093/rheumatology/20.1.1. PMID: 7221394

Recent systematic reviews

Omega-3 fatty acid supplementation for depression in children and adolescents.
Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, Korczak D
Cochrane Database Syst Rev 2024 Nov 20;11(11):CD014803. doi: 10.1002/14651858.CD014803.pub2. PMID: 39564892Free PMC Article
Movement disorders associated with neuronal antibodies: a data-driven approach.
Sturchio A, Dwivedi AK, Gastaldi M, Grimberg MB, Businaro P, Duque KR, Vizcarra JA, Abdelghany E, Balint B, Marsili L, Espay AJ
J Neurol 2022 Jul;269(7):3511-3521. Epub 2022 Jan 13 doi: 10.1007/s00415-021-10934-7. PMID: 35024921Free PMC Article
Defining idiopathic ventricular fibrillation: A systematic review of diagnostic testing yield in apparently unexplained cardiac arrest.
Alqarawi W, Dewidar O, Tadros R, Roberts JD, Steinberg C, MacIntyre CJ, Laksman ZWM, Green MS, Nair G, Wells G, Krahn AD
Heart Rhythm 2021 Jul;18(7):1178-1185. Epub 2021 Mar 26 doi: 10.1016/j.hrthm.2021.03.030. PMID: 33781978
Magnesium for skeletal muscle cramps.
Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, Sekhon RK, Dugré N
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD009402. doi: 10.1002/14651858.CD009402.pub3. PMID: 32956536Free PMC Article
Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis.
Peng JK, Hepgul N, Higginson IJ, Gao W
Palliat Med 2019 Jan;33(1):24-36. Epub 2018 Oct 22 doi: 10.1177/0269216318807051. PMID: 30345878Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...