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Vulvar keratinizing squamous cell carcinoma

MedGen UID:
378346
Concept ID:
C2109334
Neoplastic Process
Synonyms: Vulvar Keratinizing Squamous Cell Carcinoma; vulvar keratinizing squamous cell carcinoma
 
Monarch Initiative: MONDO:0004199

Definition

A squamous cell carcinoma that arises from the vulva and is characterized by the presence of keratin pearls. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar keratinizing squamous cell carcinoma

Professional guidelines

PubMed

Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, Preti M; ISSVD Difficult Pathologic Diagnoses Committee
J Low Genit Tract Dis 2021 Jan 1;25(1):57-70. doi: 10.1097/LGT.0000000000000572. PMID: 33105449Free PMC Article
Krupp P, Bohm JW, Lee FY, Collins JH
Cancer 1976 Jul;38(1 SUPPL):587-95. doi: 10.1002/1097-0142(197607)38:1<587::aid-cncr2820380183>3.0.co;2-d. PMID: 1277110
Haffner WH, Frick HC 2nd
Cancer 1970 Oct;26(4):812-5. doi: 10.1002/1097-0142(197010)26:4<812::aid-cncr2820260412>3.0.co;2-5. PMID: 5506605

Recent clinical studies

Etiology

Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, Preti M; ISSVD Difficult Pathologic Diagnoses Committee
J Low Genit Tract Dis 2021 Jan 1;25(1):57-70. doi: 10.1097/LGT.0000000000000572. PMID: 33105449Free PMC Article
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Ramos-e-Silva M, Jacques Cd, Carneiro SC
Clin Dermatol 2010 Sep-Oct;28(5):563-7. doi: 10.1016/j.clindermatol.2010.04.001. PMID: 20797520

Diagnosis

Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Day T, Marzol A, Pagano R, Jaaback K, Scurry J
J Low Genit Tract Dis 2020 Oct;24(4):392-398. doi: 10.1097/LGT.0000000000000569. PMID: 32976294Free PMC Article
Ozkan F, Bilgiç R, Cesur S
APMIS 2006 Jul-Aug;114(7-8):562-5. doi: 10.1111/j.1600-0463.2006.apm_326.x. PMID: 16907863
GREEN TH Jr, ULFELDER H, MEIGS JV
Am J Obstet Gynecol 1958 Apr;75(4):834-47. doi: 10.1016/0002-9378(58)90666-5. PMID: 13508774

Therapy

Fiset PO, Wou K, Arseneau J, Gilbert L
J Low Genit Tract Dis 2014 Jul;18(3):e74-9. doi: 10.1097/LGT.0b013e3182a82115. PMID: 24556613
Antosz Z, Poręba R, Jez W, Sioma-Markowska U
Neuro Endocrinol Lett 2011;32(4):425-7. PMID: 21876498
Dixon RS, Mikhail GR
J Am Acad Dermatol 1981 Feb;4(2):160-5. doi: 10.1016/s0190-9622(81)70019-7. PMID: 7217386
Choo YC, Morley GW
Gynecol Oncol 1980 Jun;9(3):324-33. doi: 10.1016/0090-8258(80)90044-x. PMID: 6991376
Haffner WH, Frick HC 2nd
Cancer 1970 Oct;26(4):812-5. doi: 10.1002/1097-0142(197010)26:4<812::aid-cncr2820260412>3.0.co;2-5. PMID: 5506605

Prognosis

Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Del Pino M, Rodriguez-Carunchio L, Ordi J
Histopathology 2013 Jan;62(1):161-75. Epub 2012 Nov 27 doi: 10.1111/his.12034. PMID: 23190170
SCHUELLER EF
Am J Obstet Gynecol 1965 Sep 15;93:199-208. doi: 10.1016/0002-9378(65)90659-9. PMID: 14336649

Clinical prediction guides

Stolnicu S, Allison D, Praiss AM, Tessier-Cloutier B, Momeni Boroujeni A, Flynn J, Iasonos A, Serrette R, Hoang L, Patrichi A, Terinte C, Pesci A, Mateoiu C, Lastra RR, Kiyokawa T, Ali-Fehmi R, Kheil M, Oliva E, Devins KM, Abu-Rustum NR, Soslow RA
Am J Surg Pathol 2023 Dec 1;47(12):1376-1389. Epub 2023 Sep 13 doi: 10.1097/PAS.0000000000002122. PMID: 37702216Free PMC Article
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Kim E, Chung M, Jeong HS, Baek CH, Cho J
Hum Pathol 2022 Aug;126:45-54. Epub 2022 May 18 doi: 10.1016/j.humpath.2022.05.010. PMID: 35597368
Milliken S, May J, Sanderson PA, Congiu MA, D'Oria O, Golia D'Augè T, Caruso G, DI Donato V, Benedetti Panici P, Giannini A
Minerva Obstet Gynecol 2021 Apr;73(2):160-165. Epub 2020 Dec 11 doi: 10.23736/S2724-606X.20.04743-7. PMID: 33306289
Day T, Marzol A, Pagano R, Jaaback K, Scurry J
J Low Genit Tract Dis 2020 Oct;24(4):392-398. doi: 10.1097/LGT.0000000000000569. PMID: 32976294Free PMC Article

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