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Diabetic retinopathy

MedGen UID:
3786
Concept ID:
C0011884
Disease or Syndrome
Synonyms: Diabetic Retinopathies; Diabetic Retinopathy; Retinopathies, Diabetic; Retinopathy, Diabetic
SNOMED CT: Retinal abnormality - diabetes-related (4855003); DR - Diabetic retinopathy (4855003); Retinopathy due to diabetes mellitus (4855003); Diabetic retinopathy (4855003)
 
Monarch Initiative: MONDO:0005266

Definition

A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness. [from NCI]

Professional guidelines

PubMed

Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Browning DJ, Stewart MW, Lee C
Indian J Ophthalmol 2018 Dec;66(12):1736-1750. doi: 10.4103/ijo.IJO_1240_18. PMID: 30451174Free PMC Article
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Liu Y, Wu N
Int J Nanomedicine 2021;16:1391-1403. Epub 2021 Feb 24 doi: 10.2147/IJN.S294807. PMID: 33658779Free PMC Article
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Cheung N, Mitchell P, Wong TY
Lancet 2010 Jul 10;376(9735):124-36. Epub 2010 Jun 26 doi: 10.1016/S0140-6736(09)62124-3. PMID: 20580421
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861

Diagnosis

Fung TH, Patel B, Wilmot EG, Amoaku WM
Clin Med (Lond) 2022 Mar;22(2):112-116. doi: 10.7861/clinmed.2021-0792. PMID: 35304370Free PMC Article
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Cheung N, Mitchell P, Wong TY
Lancet 2010 Jul 10;376(9735):124-36. Epub 2010 Jun 26 doi: 10.1016/S0140-6736(09)62124-3. PMID: 20580421
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article
Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT; Global Diabetic Retinopathy Project Group
Ophthalmology 2003 Sep;110(9):1677-82. doi: 10.1016/S0161-6420(03)00475-5. PMID: 13129861

Therapy

Kapoor I, Sarvepalli SM, D'Alessio D, Grewal DS, Hadziahmetovic M
Surv Ophthalmol 2023 Nov-Dec;68(6):1071-1083. Epub 2023 Jul 16 doi: 10.1016/j.survophthal.2023.07.002. PMID: 37454782
Smits MM, Van Raalte DH
Front Endocrinol (Lausanne) 2021;12:645563. Epub 2021 Jul 7 doi: 10.3389/fendo.2021.645563. PMID: 34305810Free PMC Article
Yin J, Ngiam KY, Teo HH
J Med Internet Res 2021 Apr 22;23(4):e25759. doi: 10.2196/25759. PMID: 33885365Free PMC Article
Knickelbein JE, Abbott AB, Chew EY
Curr Diab Rep 2016 Oct;16(10):90. doi: 10.1007/s11892-016-0786-7. PMID: 27525681Free PMC Article
Diabetes Care 1987 Jan-Feb;10(1):1-19. doi: 10.2337/diacare.10.1.1. PMID: 2882967

Prognosis

Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article
Quinn CJ
Optom Clin 1996;5(1):111-30. PMID: 8963073
Klein R
Annu Rev Public Health 1996;17:137-58. doi: 10.1146/annurev.pu.17.050196.001033. PMID: 8724221

Clinical prediction guides

Kwon S, Lee SR, Choi EK, Ahn HJ, Lee SW, Jung JH, Han KD, Oh S, Lip GYH
Diabetes Care 2023 Dec 1;46(12):2240-2248. doi: 10.2337/dc23-0931. PMID: 37851370
Wang W, Ji Q, Ran X, Li C, Kuang H, Yu X, Fang H, Yang J, Liu J, Xue Y, Feng B, Lei M, Zhu D
Diabetes Metab Res Rev 2023 Nov;39(8):e3702. Epub 2023 Jul 25 doi: 10.1002/dmrr.3702. PMID: 37490047
Robbins CB, Thompson AC, Bhullar PK, Koo HY, Agrawal R, Soundararajan S, Yoon SP, Polascik BW, Scott BL, Grewal DS, Fekrat S
JAMA Ophthalmol 2021 Feb 1;139(2):182-188. doi: 10.1001/jamaophthalmol.2020.5730. PMID: 33355613Free PMC Article
Wan H, Wang Y, Xiang Q, Fang S, Chen Y, Chen C, Zhang W, Zhang H, Xia F, Wang N, Lu Y
Cardiovasc Diabetol 2020 Jul 31;19(1):118. doi: 10.1186/s12933-020-01095-4. PMID: 32736628Free PMC Article
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR
JAMA 2016 Dec 13;316(22):2402-2410. doi: 10.1001/jama.2016.17216. PMID: 27898976

Recent systematic reviews

Teo ZL, Tham YC, Yu M, Chee ML, Rim TH, Cheung N, Bikbov MM, Wang YX, Tang Y, Lu Y, Wong IY, Ting DSW, Tan GSW, Jonas JB, Sabanayagam C, Wong TY, Cheng CY
Ophthalmology 2021 Nov;128(11):1580-1591. Epub 2021 May 1 doi: 10.1016/j.ophtha.2021.04.027. PMID: 33940045
Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E
Ann Intern Med 2020 Aug 18;173(4):278-286. Epub 2020 Jun 30 doi: 10.7326/M20-0864. PMID: 32598218
Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study
Lancet Glob Health 2017 Dec;5(12):e1221-e1234. Epub 2017 Oct 11 doi: 10.1016/S2214-109X(17)30393-5. PMID: 29032195
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y
Ann Med 2017 Mar;49(2):106-116. Epub 2016 Nov 3 doi: 10.1080/07853890.2016.1231932. PMID: 27585063
Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY; Meta-Analysis for Eye Disease (META-EYE) Study Group
Diabetes Care 2012 Mar;35(3):556-64. Epub 2012 Feb 1 doi: 10.2337/dc11-1909. PMID: 22301125Free PMC Article

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