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Magnocellular nevus

MedGen UID:
384467
•Concept ID:
C2004458
•
Neoplastic Process
Synonyms: Magnocellular Nevus; Melanocytoma; Melanocytoma of Eyeball; Melanocytoma of the eyeball; Melanocytoma of the Eyeball; Optic Disc Melanocytoma
SNOMED CT: Melanocytoma (26325004); Magnocellular nevus (26325004); Melanocytoma of the eyeball (26325004)

Definition

A usually benign neoplasm that arises from the sun-exposed skin, eye, and meninges. It is composed of spindle and/or epithelioid melanocytes and melanophages. It rarely progresses to melanoma. [from NCI]

Recent clinical studies

Etiology

Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345
The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group.
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM
Am J Ophthalmol 1990 Nov 15;110(5):527-34. doi: 10.1016/s0002-9394(14)77877-8. PMID: 1700611

Diagnosis

Melanocytoma (hyperpigmented magnocellular nevus) of the uveal tract: the 34th G. Victor Simpson lecture.
Shields JA, Shields CL, Eagle RC Jr
Retina 2007 Jul-Aug;27(6):730-9. doi: 10.1097/IAE.0b013e318030e81e. PMID: 17621182
Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345
Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS report no. 1.
Arch Ophthalmol 1990 Sep;108(9):1268-73. doi: 10.1001/archopht.1990.01070110084030. PMID: 2205183
Melanocytoma: nomenclature, pathogenesis, natural history and treatment.
Reidy JJ, Apple DJ, Steinmetz RL, Craythorn JM, Loftfield K, Gieser SC, Brady SE
Surv Ophthalmol 1985 Mar-Apr;29(5):319-27. doi: 10.1016/0039-6257(85)90107-9. PMID: 3992470

Therapy

The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group.
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM
Am J Ophthalmol 1990 Nov 15;110(5):527-34. doi: 10.1016/s0002-9394(14)77877-8. PMID: 1700611

Prognosis

Melanocytoma (hyperpigmented magnocellular nevus) of the uveal tract: the 34th G. Victor Simpson lecture.
Shields JA, Shields CL, Eagle RC Jr
Retina 2007 Jul-Aug;27(6):730-9. doi: 10.1097/IAE.0b013e318030e81e. PMID: 17621182
The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group.
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM
Am J Ophthalmol 1990 Nov 15;110(5):527-34. doi: 10.1016/s0002-9394(14)77877-8. PMID: 1700611

Clinical prediction guides

Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345
Melanocytoma: nomenclature, pathogenesis, natural history and treatment.
Reidy JJ, Apple DJ, Steinmetz RL, Craythorn JM, Loftfield K, Gieser SC, Brady SE
Surv Ophthalmol 1985 Mar-Apr;29(5):319-27. doi: 10.1016/0039-6257(85)90107-9. PMID: 3992470

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