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Arbovirus hemorrhagic fever

MedGen UID:: 388
•Concept ID:: C0003721
•: Disease or Syndrome

Synonyms:	Arboviral hemorrhagic fever; Arthropod-Borne Hemorrhagic Fever; Arthropod-borne hemorrhagic fever
SNOMED CT:	Arboviral hemorrhagic fever (16766000); Arbovirus hemorrhagic fever (16766000); Arthropod-borne hemorrhagic fever (16766000)

Definition

A group of viral illnesses that are vectored by arthropods, and that are characterized by increased susceptibility to bleeding diatheses. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVArbovirus hemorrhagic fever

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal homeostasis
    - Abnormality of temperature regulation
      - Fever
        Viral hemorrhagic fever
        Arbovirus hemorrhagic fever

Professional guidelines

PubMed

History and classification of Aigai virus (formerly Crimean-Congo haemorrhagic fever virus genotype VI).

Papa A, Marklewitz M, Paraskevopoulou S, Garrison AR, Alkhovsky SV, Avšič-Županc T, Bente DA, Bergeron É, Burt F, Di Paola N, Ergünay K, Hewson R, Mirazimi A, Sall AA, Spengler JR, Postler TS, Palacios G, Kuhn JH
J Gen Virol 2022 Apr;103(4) doi: 10.1099/jgv.0.001734. PMID: 35412967 Free PMC Article

Early Genomic Detection of Cosmopolitan Genotype of Dengue Virus Serotype 2, Angola, 2018.

Hill SC, Neto de Vasconcelos J, Granja BG, Thézé J, Jandondo D, Neto Z, Mirandela M, Sebastião CDS, Cândido ALM, Clemente C, Pereira da Silva S, de Oliveira T, Pybus OG, Faria NR, Afonso JM
Emerg Infect Dis 2019 Apr;25(4):784-787. doi: 10.3201/eid2504.180958. PMID: 30882320 Free PMC Article

Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?

Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425

See all (41)

Recent clinical studies

Etiology

Dengue, chikungunya and zika arbovirus infections in Caribbean children.

Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979 Free PMC Article

Dengue: A Growing Problem With New Interventions.

Wong JM, Adams LE, Durbin AP, Muñoz-Jordán JL, Poehling KA, Sánchez-González LM, Volkman HR, Paz-Bailey G
Pediatrics 2022 Jun 1;149(6) doi: 10.1542/peds.2021-055522. PMID: 35543085

Insect-Specific Viruses: An overview and their relationship to arboviruses of concern to humans and animals.

Carvalho VL, Long MT
Virology 2021 May;557:34-43. Epub 2021 Feb 9 doi: 10.1016/j.virol.2021.01.007. PMID: 33631523

Dengue vaccine development: status and future.

Wilder-Smith A
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020 Jan;63(1):40-44. doi: 10.1007/s00103-019-03060-3. PMID: 31784763 Free PMC Article

Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?

Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425

See all (611)

Diagnosis

Dengue, chikungunya and zika arbovirus infections in Caribbean children.

Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979 Free PMC Article

Dengue: A Growing Problem With New Interventions.

Wong JM, Adams LE, Durbin AP, Muñoz-Jordán JL, Poehling KA, Sánchez-González LM, Volkman HR, Paz-Bailey G
Pediatrics 2022 Jun 1;149(6) doi: 10.1542/peds.2021-055522. PMID: 35543085

Dengue vaccine development: status and future.

Wilder-Smith A
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020 Jan;63(1):40-44. doi: 10.1007/s00103-019-03060-3. PMID: 31784763 Free PMC Article

History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review.

Salles TS, da Encarnação Sá-Guimarães T, de Alvarenga ESL, Guimarães-Ribeiro V, de Meneses MDF, de Castro-Salles PF, Dos Santos CR, do Amaral Melo AC, Soares MR, Ferreira DF, Moreira MF
Parasit Vectors 2018 Apr 24;11(1):264. doi: 10.1186/s13071-018-2830-8. PMID: 29690895 Free PMC Article

Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity.

Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M
Antiviral Res 2013 Oct;100(1):159-89. Epub 2013 Jul 29 doi: 10.1016/j.antiviral.2013.07.006. PMID: 23906741

See all (585)

Therapy

Novel chikungunya and dengue vaccines: travel medicine applications.

Steffen R, Hamer DH, Chen LH, Caumes E, Lau CL
J Travel Med 2024 Jun 3;31(4) doi: 10.1093/jtm/taae064. PMID: 38637307

Anti-dengue Vaccines: From Development to Clinical Trials.

Pinheiro-Michelsen JR, Souza RDSO, Santana IVR, da Silva PS, Mendez EC, Luiz WB, Amorim JH
Front Immunol 2020;11:1252. Epub 2020 Jun 18 doi: 10.3389/fimmu.2020.01252. PMID: 32655561 Free PMC Article

Systematic review of dengue vaccine efficacy.

da Silveira LTC, Tura B, Santos M
BMC Infect Dis 2019 Aug 28;19(1):750. doi: 10.1186/s12879-019-4369-5. PMID: 31455279 Free PMC Article

Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?

Kellstein D, Fernandes L
Postgrad Med 2019 Mar;131(2):109-116. Epub 2019 Jan 16 doi: 10.1080/00325481.2019.1561916. PMID: 30575425

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG
Cell Host Microbe 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010. PMID: 29324233

See all (145)

Prognosis

ZIKV B-cell epitopes for immunodiagnostic tests.

Kubiszeski JR, da Silva DJF, Menezes GL, da Silva RA, Zini N, Nogueira ML, Pena LJ, Piccoli JP, Cilli EM, da Silva JM, Bronzoni RVM
J Immunol Methods 2022 May;504:113246. Epub 2022 Mar 11 doi: 10.1016/j.jim.2022.113246. PMID: 35288195

Concurrent dengue infections: Epidemiology & clinical implications.

N Sirisena PDN, Mahilkar S, Sharma C, Jain J, Sunil S
Indian J Med Res 2021 May;154(5):669-679. doi: 10.4103/ijmr.IJMR_1219_18. PMID: 35532585 Free PMC Article

Challenges and opportunities in controlling mosquito-borne infections.

Ferguson NM
Nature 2018 Jul;559(7715):490-497. Epub 2018 Jul 25 doi: 10.1038/s41586-018-0318-5. PMID: 30046071

Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges.

Leblebicioglu H, Ozaras R, Irmak H, Sencan I
Antiviral Res 2016 Feb;126:21-34. Epub 2015 Dec 13 doi: 10.1016/j.antiviral.2015.12.003. PMID: 26695860

Yellow fever.

Monath TP, Vasconcelos PF
J Clin Virol 2015 Mar;64:160-73. Epub 2014 Oct 24 doi: 10.1016/j.jcv.2014.08.030. PMID: 25453327

See all (264)

Clinical prediction guides

Dengue, chikungunya and zika arbovirus infections in Caribbean children.

Christie CDC, Lue AM, Melbourne-Chambers RH
Curr Opin Pediatr 2023 Apr 1;35(2):155-165. Epub 2023 Feb 22 doi: 10.1097/MOP.0000000000001229. PMID: 36801979 Free PMC Article

Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins.

Benfrid S, Park KH, Dellarole M, Voss JE, Tamietti C, Pehau-Arnaudet G, Raynal B, Brûlé S, England P, Zhang X, Mikhailova A, Hasan M, Ungeheuer MN, Petres S, Biering SB, Harris E, Sakuntabhai A, Buchy P, Duong V, Dussart P, Coulibaly F, Bontems F, Rey FA, Flamand M
EMBO Rep 2022 Jul 5;23(7):e53600. Epub 2022 May 24 doi: 10.15252/embr.202153600. PMID: 35607830 Free PMC Article

ZIKV B-cell epitopes for immunodiagnostic tests.

Molecular Aspects of the Dengue Virus Infection Process: A Review.

Zonetti LFC, Coutinho MC, de Araujo AS
Protein Pept Lett 2018;25(8):712-719. doi: 10.2174/0929866525666180709115506. PMID: 29984641

Climatic and geographic influences on arboviral infections and vectors.

Mellor PS, Leake CJ
Rev Sci Tech 2000 Apr;19(1):41-54. doi: 10.20506/rst.19.1.1211. PMID: 11189725

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Recent systematic reviews

Dengue fever in immunocompromised patients: A systematic review and meta-analysis.

Sohail A, Zhong S, Nguyen PY, McGuinness SL, Leder K
Int J Infect Dis 2024 Dec;149:107272. Epub 2024 Oct 28 doi: 10.1016/j.ijid.2024.107272. PMID: 39490806

The Others: A Systematic Review of the Lesser-Known Arboviruses of the Insular Caribbean.

Ali I, Alarcόn-Elbal PM, Mundle M, Noble SAA, Oura CAL, Anzinger JJ, Sandiford SL
Viruses 2023 Mar 25;15(4) doi: 10.3390/v15040843. PMID: 37112824 Free PMC Article

Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis.

Nicacio JM, Gomes OV, Carmo RFD, Nunes SLP, Rocha JRCF, Souza CDF, Franca RFO, Khouri R, Barral-Netto M, Armstrong ADC
Viruses 2022 Sep 8;14(9) doi: 10.3390/v14091988. PMID: 36146794 Free PMC Article

Systematic review of dengue vaccine efficacy.

da Silveira LTC, Tura B, Santos M
BMC Infect Dis 2019 Aug 28;19(1):750. doi: 10.1186/s12879-019-4369-5. PMID: 31455279 Free PMC Article

ANTI-VIRAL EFFECTS OF MEDICINAL PLANTS IN THE MANAGEMENT OF DENGUE: A SYSTEMATIC REVIEW.

Frederico ÉHFF, Cardoso ALBD, Moreira-Marconi E, de Sá-Caputo DDC, Guimarães CAS, Dionello CDF, Morel DS, Paineiras-Domingos LL, de Souza PL, Brandão-Sobrinho-Neto S, Carvalho-Lima RP, Guedes-Aguiar EO, Costa-Cavalcanti RG, Kutter CR, Bernardo-Filho M
Afr J Tradit Complement Altern Med 2017;14(4 Suppl):33-40. Epub 2017 Jul 7 doi: 10.21010/ajtcam.v14i4S.5. PMID: 28740942 Free PMC Article

See all (27)

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Arbovirus hemorrhagic fever

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity