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Ovarian hyperstimulation syndrome(OHSS)

MedGen UID:
38966
Concept ID:
C0085083
Disease or Syndrome
Synonyms: OHSS; OVARIAN HYPERSTIMULATION SYNDROME, FAMILIAL GESTATIONAL SPONTANEOUS
SNOMED CT: Secondary Meig's syndrome (129635004); Ovarian hyperstimulation syndrome (129635004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Gene (location): FSHR (2p16.3)
 
Monarch Initiative: MONDO:0011972
OMIM®: 608115
Orphanet: ORPHA64739

Definition

A rare non-malformative gynecological disease affecting pre-menopausal women usually following treatment with ovarian stimulating hormones, characterized by ovarian enlargement and, to varying degrees, shift of serum from the intravascular space to the third space, mainly into the peritoneal, pleural, and to a lesser extent to the pericardial cavities. Presenting symptoms include abdomen distention, pain, nausea, and vomiting. Severity ranges from mild to life-threatening and is complicated by increased risk of thrombosis, acute hepato-renal failure, acute respiratory distress syndrome, and ovarian torsion and rupture. [from ORDO]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Abnormality of the genitourinary system
MedGen UID:
52948
Concept ID:
C0042063
Congenital Abnormality
The presence of any abnormality of the genitourinary system.
Ascites
MedGen UID:
416
Concept ID:
C0003962
Disease or Syndrome
Accumulation of fluid in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen).
Nausea
MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian hyperstimulation syndrome
Follow this link to review classifications for Ovarian hyperstimulation syndrome in Orphanet.

Professional guidelines

PubMed

Carson SA, Kallen AN
JAMA 2021 Jul 6;326(1):65-76. doi: 10.1001/jama.2021.4788. PMID: 34228062Free PMC Article
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032

Recent clinical studies

Etiology

Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Nelson SM
Thromb Res 2017 Mar;151 Suppl 1:S61-S64. doi: 10.1016/S0049-3848(17)30070-1. PMID: 28262238
Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032
Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2004 Sep;82 Suppl 1:S81-6. doi: 10.1016/j.fertnstert.2004.05.005. PMID: 15363699
Practice Committe of the American Society for Reproductive Medicine
Fertil Steril 2003 Nov;80(5):1309-14. doi: 10.1016/s0015-0282(03)02194-0. PMID: 14607613

Diagnosis

Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Ay ZA, Abali S, Korkmaz A, Beken S
Pediatr Neonatol 2023 Nov;64(6):690-691. Epub 2023 Jun 16 doi: 10.1016/j.pedneo.2023.04.008. PMID: 37380551
Timmons D, Montrief T, Koyfman A, Long B
Am J Emerg Med 2019 Aug;37(8):1577-1584. Epub 2019 May 7 doi: 10.1016/j.ajem.2019.05.018. PMID: 31097257
Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032
Practice Committee of American Society for Reproductive Medicine
Fertil Steril 2008 Nov;90(5 Suppl):S188-93. doi: 10.1016/j.fertnstert.2008.08.034. PMID: 19007627

Therapy

Rosenberg H, Rangwala S, Magee B
CMAJ 2024 Sep 9;196(29):E1012. doi: 10.1503/cmaj.240213. PMID: 39251242Free PMC Article
Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P
Int J Mol Sci 2023 Sep 16;24(18) doi: 10.3390/ijms241814185. PMID: 37762488Free PMC Article
Guan S, Feng Y, Huang Y, Huang J
Front Endocrinol (Lausanne) 2021;12:702558. Epub 2021 Aug 31 doi: 10.3389/fendo.2021.702558. PMID: 34531825Free PMC Article
Tanbo T, Mellembakken J, Bjercke S, Ring E, Åbyholm T, Fedorcsak P
Acta Obstet Gynecol Scand 2018 Oct;97(10):1162-1167. Epub 2018 Jul 24 doi: 10.1111/aogs.13395. PMID: 29889977
Rosenwaks Z, Benadiva C
Semin Reprod Med 2010 Nov;28(6):437-9. Epub 2010 Nov 16 doi: 10.1055/s-0030-1265668. PMID: 21082500

Prognosis

Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P
Int J Mol Sci 2023 Sep 16;24(18) doi: 10.3390/ijms241814185. PMID: 37762488Free PMC Article
Kotlyar AM, Seifer DB
Reprod Biol Endocrinol 2023 Aug 1;21(1):70. doi: 10.1186/s12958-023-01120-7. PMID: 37528417Free PMC Article
Palomba S, Costanzi F, Nelson SM, Caserta D, Humaidan P
Reprod Biol Endocrinol 2023 Jul 21;21(1):67. doi: 10.1186/s12958-023-01113-6. PMID: 37480081Free PMC Article
Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, Dai S, Sun Y
Front Endocrinol (Lausanne) 2020;11:615957. Epub 2021 Jan 19 doi: 10.3389/fendo.2020.615957. PMID: 33542709Free PMC Article
Moolhuijsen LME, Visser JA
J Clin Endocrinol Metab 2020 Nov 1;105(11):3361-73. doi: 10.1210/clinem/dgaa513. PMID: 32770239Free PMC Article

Clinical prediction guides

Li Y, Hao Z
Gynecol Endocrinol 2022 Nov;38(11):1008-1013. Epub 2022 Sep 19 doi: 10.1080/09513590.2022.2122429. PMID: 36123800
Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, Dai S, Sun Y
Front Endocrinol (Lausanne) 2020;11:615957. Epub 2021 Jan 19 doi: 10.3389/fendo.2020.615957. PMID: 33542709Free PMC Article
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Aboulghar M
Fertil Steril 2012 Mar;97(3):523-6. Epub 2012 Jan 20 doi: 10.1016/j.fertnstert.2012.01.094. PMID: 22265033
Espinoza J, Uckele JE, Starr RA, Seubert DE, Espinoza AF, Berry SM
Am J Obstet Gynecol 2010 Jul;203(1):17.e1-8. Epub 2010 Mar 15 doi: 10.1016/j.ajog.2009.10.891. PMID: 20231008

Recent systematic reviews

Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, Yasmin E
J Clin Endocrinol Metab 2021 Jul 13;106(8):2436-2446. doi: 10.1210/clinem/dgab232. PMID: 33839790Free PMC Article
Farquhar C, Marjoribanks J
Cochrane Database Syst Rev 2018 Aug 17;8(8):CD010537. doi: 10.1002/14651858.CD010537.pub5. PMID: 30117155Free PMC Article
Practice Committee of the American Society for Reproductive Medicine. Electronic address: [email protected]; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

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