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Microsporidiosis

MedGen UID:
39278
•Concept ID:
C0085407
•
Disease or Syndrome
Synonym: Microsporidiasis
SNOMED CT: Infection by Microspora (65883009); Infection by Microsporidia (699676006); Microsporidiosis (699676006); Infection caused by Microsporidia (699676006); Infection caused by Microspora (65883009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005846
Orphanet: ORPHA2552

Definition

Microsporidiosis is a parasitosis caused by microsporidia (protozoan parasites). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrosporidiosis
Follow this link to review classifications for Microsporidiosis in Orphanet.

Professional guidelines

PubMed

Safety and efficacy of fumagillin for the treatment of intestinal microsporidiosis. A French prospective cohort study.
Maillard A, Scemla A, Laffy B, Mahloul N, Molina JM
J Antimicrob Chemother 2021 Jan 19;76(2):487-494. doi: 10.1093/jac/dkaa438. PMID: 33128055
Therapeutic targets for the treatment of microsporidiosis in humans.
Han B, Weiss LM
Expert Opin Ther Targets 2018 Nov;22(11):903-915. Epub 2018 Nov 1 doi: 10.1080/14728222.2018.1538360. PMID: 30336698Free PMC Article
Prevalence and genotypes of Enterocytozoon bieneusi in China.
Wang SS, Wang RJ, Fan XC, Liu TL, Zhang LX, Zhao GH
Acta Trop 2018 Jul;183:142-152. Epub 2018 Apr 13 doi: 10.1016/j.actatropica.2018.04.017. PMID: 29660311

Recent clinical studies

Etiology

Microsporidiosis in Humans.
Han B, Pan G, Weiss LM
Clin Microbiol Rev 2021 Dec 15;34(4):e0001020. Epub 2021 Jun 30 doi: 10.1128/CMR.00010-20. PMID: 34190570Free PMC Article
Host Specificity of Enterocytozoon bieneusi and Public Health Implications.
Li W, Feng Y, Santin M
Trends Parasitol 2019 Jun;35(6):436-451. Epub 2019 May 7 doi: 10.1016/j.pt.2019.04.004. PMID: 31076351
Microsporidia-host interactions.
Szumowski SC, Troemel ER
Curr Opin Microbiol 2015 Aug;26:10-6. Epub 2015 Apr 4 doi: 10.1016/j.mib.2015.03.006. PMID: 25847674Free PMC Article
Microsporidiosis: epidemiology, clinical data and therapy.
Anane S, Attouchi H
Gastroenterol Clin Biol 2010 Sep;34(8-9):450-64. Epub 2010 Aug 10 doi: 10.1016/j.gcb.2010.07.003. PMID: 20702053
Microsporidiosis: current status.
Didier ES, Weiss LM
Curr Opin Infect Dis 2006 Oct;19(5):485-92. doi: 10.1097/01.qco.0000244055.46382.23. PMID: 16940873Free PMC Article

Diagnosis

Microsporidiosis in Humans.
Han B, Pan G, Weiss LM
Clin Microbiol Rev 2021 Dec 15;34(4):e0001020. Epub 2021 Jun 30 doi: 10.1128/CMR.00010-20. PMID: 34190570Free PMC Article
Extraintestinal microsporidiosis.
Ramanan P, Pritt BS
J Clin Microbiol 2014 Nov;52(11):3839-44. Epub 2014 May 14 doi: 10.1128/JCM.00971-14. PMID: 24829239Free PMC Article
Microsporidiasis.
Ashfaq A, White AC Jr
Handb Clin Neurol 2013;114:183-91. doi: 10.1016/B978-0-444-53490-3.00012-1. PMID: 23829908
Diarrhea in the immunocompromised patient.
Krones E, Högenauer C
Gastroenterol Clin North Am 2012 Sep;41(3):677-701. Epub 2012 Jul 4 doi: 10.1016/j.gtc.2012.06.009. PMID: 22917171
Microsporidiosis: current status.
Didier ES, Weiss LM
Curr Opin Infect Dis 2006 Oct;19(5):485-92. doi: 10.1097/01.qco.0000244055.46382.23. PMID: 16940873Free PMC Article

Therapy

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update.
Chai JY, Jung BK, Hong SJ
Korean J Parasitol 2021 Jun;59(3):189-225. Epub 2021 Jun 21 doi: 10.3347/kjp.2021.59.3.189. PMID: 34218593Free PMC Article
Diarrhea in the immunocompromised patient.
Krones E, Högenauer C
Gastroenterol Clin North Am 2012 Sep;41(3):677-701. Epub 2012 Jul 4 doi: 10.1016/j.gtc.2012.06.009. PMID: 22917171
Microsporidiosis: not just in AIDS patients.
Didier ES, Weiss LM
Curr Opin Infect Dis 2011 Oct;24(5):490-5. doi: 10.1097/QCO.0b013e32834aa152. PMID: 21844802Free PMC Article
Microsporidiosis: epidemiology, clinical data and therapy.
Anane S, Attouchi H
Gastroenterol Clin Biol 2010 Sep;34(8-9):450-64. Epub 2010 Aug 10 doi: 10.1016/j.gcb.2010.07.003. PMID: 20702053
Microsporidiosis.
Treat Rev 1995 May;(no 18):9. PMID: 11362599

Prognosis

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
Anncaliia algerae microsporidial myositis.
Watts MR, Chan RC, Cheong EY, Brammah S, Clezy KR, Tong C, Marriott D, Webb CE, Chacko B, Tobias V, Outhred AC, Field AS, Prowse MV, Bertouch JV, Stark D, Reddel SW
Emerg Infect Dis 2014 Feb;20(2):185-91. doi: 10.3201/eid2002.131126. PMID: 24447398Free PMC Article
Clinical spectrum of microsporidial keratoconjunctivitis.
Tham AC, Sanjay S
Clin Exp Ophthalmol 2012 Jul;40(5):512-8. Epub 2011 Dec 6 doi: 10.1111/j.1442-9071.2011.02712.x. PMID: 22003887
The ecology and evolution of microsporidian parasites.
Smith JE
Parasitology 2009 Dec;136(14):1901-14. doi: 10.1017/S0031182009991818. PMID: 19995469
Microsporidiosis as an AIDS-related opportunistic infection.
Bryan RT
Clin Infect Dis 1995 Aug;21 Suppl 1:S62-5. doi: 10.1093/clinids/21.supplement_1.s62. PMID: 8547514

Clinical prediction guides

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
Prevalence and genotypes of Enterocytozoon bieneusi in China.
Wang SS, Wang RJ, Fan XC, Liu TL, Zhang LX, Zhao GH
Acta Trop 2018 Jul;183:142-152. Epub 2018 Apr 13 doi: 10.1016/j.actatropica.2018.04.017. PMID: 29660311
The ecology and evolution of microsporidian parasites.
Smith JE
Parasitology 2009 Dec;136(14):1901-14. doi: 10.1017/S0031182009991818. PMID: 19995469
Thalidomide: a re-look.
Grover JK, Vats V, Gopalakrishna R, Ramam M
Natl Med J India 2000 May-Jun;13(3):132-41. PMID: 11558112
Human microsporidial infections.
Weber R, Bryan RT, Schwartz DA, Owen RL
Clin Microbiol Rev 1994 Oct;7(4):426-61. doi: 10.1128/CMR.7.4.426. PMID: 7834600Free PMC Article

Recent systematic reviews

Global prevalence and risk factors of Enterocytozoon bieneusi infection in humans: a systematic review and meta-analysis.
Wang Y, Li XM, Yang X, Wang XY, Wei YJ, Cai Y, Geng HL, Yang XB, Yu HL, Cao H, Jiang J
Parasite 2024;31:9. Epub 2024 Feb 9 doi: 10.1051/parasite/2024007. PMID: 38345479Free PMC Article
Global prevalence and genotype distribution of Microsporidia spp. in various consumables: a systematic review and meta-analysis.
Rezaeian S, Taghipour A, Bahadory S, Mogharab V, Abdoli A
J Water Health 2023 Jul;21(7):895-914. doi: 10.2166/wh.2023.042. PMID: 37515561
Prevalence and related factors of Enterocytozoon bieneusi in cattle: A global systematic review and meta-analysis.
Qin Y, Chen C, Qin YF, Yang XB, Li MH, Meng XZ, Zhao ZY, Ma N, Cai Y, Zhang Y, Zhao Q
Prev Vet Med 2022 Nov;208:105775. Epub 2022 Oct 6 doi: 10.1016/j.prevetmed.2022.105775. PMID: 36265298
The prevalence of microsporidia in China : A systematic review and meta-analysis.
Qiu L, Xia W, Li W, Ping J, Ding S, Liu H
Sci Rep 2019 Feb 28;9(1):3174. doi: 10.1038/s41598-019-39290-3. PMID: 30816168Free PMC Article
Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: a global systematic review and meta-analysis.
Wang ZD, Liu Q, Liu HH, Li S, Zhang L, Zhao YK, Zhu XQ
Parasit Vectors 2018 Jan 9;11(1):28. doi: 10.1186/s13071-017-2558-x. PMID: 29316950Free PMC Article

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