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Carcinoma 256, Walker

MedGen UID:
40098
•Concept ID:
C0007098
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Carcinosarcoma 256, Walker; Walker Carcinoma 256; Walker Carcinosarcoma 256

Definition

A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma 256, Walker

Professional guidelines

PubMed

Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Nakagawa H, Yamada M, Fukushima M, Ikenaka K
Cancer Chemother Pharmacol 1999;43(3):247-56. doi: 10.1007/s002800050891. PMID: 9923556

Recent clinical studies

Etiology

Laser-photobiomodulation on experimental cancer pain model in Walker Tumor-256.
Petrellis MC, da Fonseca GAMD, de Barros Pinto A, Rosa FO, Maria DA, Shibli JA, Frigo L
J Photochem Photobiol B 2020 Sep;210:111979. Epub 2020 Jul 26 doi: 10.1016/j.jphotobiol.2020.111979. PMID: 32738748
Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats.
Cruz BL, da Silva PC, Tomasin R, Oliveira AG, Viana LR, Salomao EM, Gomes-Marcondes MC
BMC Cancer 2016 Feb 4;16:58. doi: 10.1186/s12885-016-2103-x. PMID: 26847205Free PMC Article
Metabolic and hematological effects of dietary supplementation with arginine on rats bearing ascitic Walker 256 tumor.
Novaes MR, Lima LA, Novaes LC, Souza MV
Ann Nutr Metab 2004 Nov-Dec;48(6):404-8. Epub 2004 Nov 30 doi: 10.1159/000082467. PMID: 15583469
CB 1954: from the Walker tumor to NQO2 and VDEPT.
Knox RJ, Burke PJ, Chen S, Kerr DJ
Curr Pharm Des 2003;9(26):2091-104. doi: 10.2174/1381612033454108. PMID: 14529407
Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
Bailey SM, Lewis AD, Knox RJ, Patterson LH, Fisher GR, Workman P
Biochem Pharmacol 1998 Sep 1;56(5):613-21. doi: 10.1016/s0006-2952(97)00661-8. PMID: 9783730

Diagnosis

CB 1954: from the Walker tumor to NQO2 and VDEPT.
Knox RJ, Burke PJ, Chen S, Kerr DJ
Curr Pharm Des 2003;9(26):2091-104. doi: 10.2174/1381612033454108. PMID: 14529407
Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
Bailey SM, Lewis AD, Knox RJ, Patterson LH, Fisher GR, Workman P
Biochem Pharmacol 1998 Sep 1;56(5):613-21. doi: 10.1016/s0006-2952(97)00661-8. PMID: 9783730
B-859-35, a new drug with anti-tumor activity reverses multi-drug resistance.
Hofmann J, Ueberall F, Egle A, Grunicke H
Int J Cancer 1991 Apr 1;47(6):870-4. doi: 10.1002/ijc.2910470614. PMID: 1849122
Animal models of nonthyroidal disease.
Tibaldi JM, Surks MI
Endocr Rev 1985 Winter;6(1):87-102. doi: 10.1210/edrv-6-1-87. PMID: 3884330
Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Tew KD, Hartley-Asp B
Urology 1984 Jun;23(6 Suppl):28-33. doi: 10.1016/s0090-4295(84)80094-1. PMID: 6730140

Therapy

Novel polymeric microspheres containing norcantharidin for chemoembolization.
Liu X, Heng WS, Paul, Li Q, Chan LW
J Control Release 2006 Nov;116(1):35-41. Epub 2006 Sep 8 doi: 10.1016/j.jconrel.2006.08.022. PMID: 17050026
Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity.
Rao VS, Almeida FR, Moraes AP, Silva JV, Nascimento SC, Moraes MO
Mem Inst Oswaldo Cruz 1991;86 Suppl 2:43-5. doi: 10.1590/s0074-02761991000600012. PMID: 1842011
Sequential methotrexate (MTX) and 5-fluorouracil (FU) in human tumor xenografts.
Wayss K, Herrmann R, Mattern J, Volm M
Med Oncol Tumor Pharmacother 1985;2(1):27-32. doi: 10.1007/BF02934777. PMID: 4058075
Trichlorotriethylamine hydrochloride.
IARC Monogr Eval Carcinog Risk Chem Man 1975;9:229-34. PMID: 791837
New approaches to chemotherapy with folate antagonists: use of leucovorin "rescue" and enzymic folate depletion.
Bertino JR, Levitt M, McCullough JL, Chabner B
Ann N Y Acad Sci 1971 Nov 30;186:486-95. PMID: 4943812

Prognosis

Asparagus polysaccharide and gum with hepatic artery embolization induces tumor growth and inhibits angiogenesis in an orthotopic hepatocellular carcinoma model.
Weng LL, Xiang JF, Lin JB, Yi SH, Yang LT, Li YS, Zeng HT, Lin SM, Xin DW, Zhao HL, Qiu SQ, Chen T, Zhang MG
Asian Pac J Cancer Prev 2014;15(24):10949-55. doi: 10.7314/apjcp.2014.15.24.10949. PMID: 25605207
Metabolic and hematological effects of dietary supplementation with arginine on rats bearing ascitic Walker 256 tumor.
Novaes MR, Lima LA, Novaes LC, Souza MV
Ann Nutr Metab 2004 Nov-Dec;48(6):404-8. Epub 2004 Nov 30 doi: 10.1159/000082467. PMID: 15583469
Protrusive activity quantitatively determines the rate and direction of cell locomotion.
Keller HU, Bebie H
Cell Motil Cytoskeleton 1996;33(4):241-51. doi: 10.1002/(SICI)1097-0169(1996)33:4<241::AID-CM1>3.0.CO;2-C. PMID: 8801030
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).
Knox RJ, Friedlos F, Boland MP
Cancer Metastasis Rev 1993 Jun;12(2):195-212. doi: 10.1007/BF00689810. PMID: 8375021
Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Tew KD, Hartley-Asp B
Urology 1984 Jun;23(6 Suppl):28-33. doi: 10.1016/s0090-4295(84)80094-1. PMID: 6730140

Clinical prediction guides

Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death.
Song CW, Glatstein E, Marks LB, Emami B, Grimm J, Sperduto PW, Kim MS, Hui S, Dusenbery KE, Cho LC
Int J Radiat Oncol Biol Phys 2021 May 1;110(1):21-34. Epub 2019 Mar 2 doi: 10.1016/j.ijrobp.2019.02.047. PMID: 30836165
Solute-dependent activation of cell motility in strongly hypertonic solutions in Dictyostelium discoideum, human melanoma HTB-140 cells and walker 256 carcinosarcoma cells.
Korohoda W, Kucia M, Wybieralska E, Wianecka-Skoczeń M, Waligórska A, Drukała J, Madeja Z
Cell Mol Biol Lett 2011 Sep;16(3):412-30. Epub 2011 May 25 doi: 10.2478/s11658-011-0015-y. PMID: 21614489Free PMC Article
The loading rate determines tumor targeting properties of methotrexate-albumin conjugates in rats.
Stehle G, Sinn H, Wunder A, Schrenk HH, Schütt S, Maier-Borst W, Heene DL
Anticancer Drugs 1997 Aug;8(7):677-85. PMID: 9311444
Depression of catalase gene expression in the liver of tumor bearing nude mice.
Yamaguchi Y, Sato K, Endo H
Biochem Biophys Res Commun 1992 Dec 15;189(2):1084-9. doi: 10.1016/0006-291x(92)92315-o. PMID: 1472018
Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Tew KD, Hartley-Asp B
Urology 1984 Jun;23(6 Suppl):28-33. doi: 10.1016/s0090-4295(84)80094-1. PMID: 6730140

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