U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cerebellar disorder

MedGen UID:
40186
Concept ID:
C0007760
Disease or Syndrome
Synonym: Cerebellar disease
SNOMED CT: Cerebellar disorder (223176004); Cerebellar syndrome (224186005); Cerebellar deficiency syndrome (224186005)
 
Monarch Initiative: MONDO:0002427

Definition

Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebellar disorder

Professional guidelines

PubMed

Koutsis G, Kartanou C, Kontogeorgiou Z, Koniari C, Mitrousias A, Pellerin D, Dicaire MJ, Iruzubieta P, Danzi MC, Athanassopoulos K, Ragazos N, Stamelou M, Rentzos M, Anagnostou E, Zuchner S, Brais B, Houlden H, Panas M, Stefanis L, Karadima G
J Neurol Sci 2024 Dec 15;467:123309. Epub 2024 Nov 15 doi: 10.1016/j.jns.2024.123309. PMID: 39571249
Strupp M, Kalla R, Glasauer S, Wagner J, Hüfner K, Jahn K, Brandt T
Prog Brain Res 2008;171:535-41. doi: 10.1016/S0079-6123(08)00676-6. PMID: 18718350

Recent clinical studies

Etiology

De T, Sharma P, Upilli B, Vivekanand A, Bari S, Sonakar AK, Srivastava AK, Faruq M
Neurogenetics 2024 Oct;25(4):393-403. Epub 2024 Jul 8 doi: 10.1007/s10048-024-00770-y. PMID: 38976084
Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H; Encephalitis Collaborative Group
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Sep 27 doi: 10.1212/NXI.0000000000001077. PMID: 34580182Free PMC Article
Zanni G, Bertini E
Handb Clin Neurol 2018;155:175-189. doi: 10.1016/B978-0-444-64189-2.00011-1. PMID: 29891057

Diagnosis

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Liu M, Ren H, Fan S, Zhang W, Xu Y, Zhao W, Guan H; Encephalitis Collaborative Group
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Sep 27 doi: 10.1212/NXI.0000000000001077. PMID: 34580182Free PMC Article
Zhou L, Luo L, Hui X, You C, Yang Y, Xu J
J Clin Neurosci 2009 Jan;16(1):124-7. Epub 2008 Nov 14 doi: 10.1016/j.jocn.2008.02.023. PMID: 19013808
Yesildağ A, Baykal B, Ayata A, Kerman G, Koroglu M, Olgar S, Oyar O
Acta Radiol 2005 Feb;46(1):97-100. doi: 10.1080/02841850510020932. PMID: 15841746
Stollhoff K, Albani M, Goebel HH
Pediatr Neurol 1991 Jan-Feb;7(1):69-71. doi: 10.1016/0887-8994(91)90111-w. PMID: 2029298

Therapy

Marmol S, Beltre N, Margolesky J
Cerebellum 2024 Aug;23(4):1733-1735. Epub 2024 Feb 7 doi: 10.1007/s12311-024-01668-z. PMID: 38321324
Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Isotalo E, Heikki A, Ilmari P
Auris Nasus Larynx 2009 Feb;36(1):36-41. Epub 2008 May 22 doi: 10.1016/j.anl.2008.03.010. PMID: 18501541
Furtado S, Payami H, Lockhart PJ, Hanson M, Nutt JG, Singleton AA, Singleton A, Bower J, Utti RJ, Bird TD, de la Fuente-Fernandez R, Tsuboi Y, Klimek ML, Suchowersky O, Hardy J, Calne DB, Wszolek ZK, Farrer M, Gwinn-Hardy K, Stoessl AJ
Mov Disord 2004 Jun;19(6):622-9. doi: 10.1002/mds.20074. PMID: 15197699
Michotte A, Van Dijck I, Maes V, D'Haenen H
Eur Neurol 1989;29(1):23-6. doi: 10.1159/000116371. PMID: 2707289

Prognosis

Nanetti L, Magri S, Fichera M, Castaldo A, Nigri A, Pinardi C, Mongelli A, Sarro L, Pareyson D, Grisoli M, Gellera C, Di Bella D, Mariotti C, Taroni F
Mov Disord 2023 Apr;38(4):665-675. Epub 2023 Feb 17 doi: 10.1002/mds.29352. PMID: 36799493
Fitzpatrick LE, Crowe SF
Cerebellum 2013 Aug;12(4):520-33. doi: 10.1007/s12311-013-0461-3. PMID: 23436003
Brodsky MC
Arch Ophthalmol 2012 Sep;130(9):1199-202. doi: 10.1001/archophthalmol.2012.2067. PMID: 22965598
McKeon A, Tracy JA, Pittock SJ, Parisi JE, Klein CJ, Lennon VA
Arch Neurol 2011 Oct;68(10):1282-9. Epub 2011 Jun 13 doi: 10.1001/archneurol.2011.128. PMID: 21670387
Hottinger-Blanc PM, Ziegler AL, Deonna T
Eur J Paediatr Neurol 2002;6(3):143-52. doi: 10.1053/ejpn.2002.0582. PMID: 12363101

Clinical prediction guides

De T, Sharma P, Upilli B, Vivekanand A, Bari S, Sonakar AK, Srivastava AK, Faruq M
Neurogenetics 2024 Oct;25(4):393-403. Epub 2024 Jul 8 doi: 10.1007/s10048-024-00770-y. PMID: 38976084
Mailankody S, Devlin SM, Landa J, Nath K, Diamonte C, Carstens EJ, Russo D, Auclair R, Fitzgerald L, Cadzin B, Wang X, Sikder D, Senechal B, Bermudez VP, Purdon TJ, Hosszu K, McAvoy DP, Farzana T, Mead E, Wilcox JA, Santomasso BD, Shah GL, Shah UA, Korde N, Lesokhin A, Tan CR, Hultcrantz M, Hassoun H, Roshal M, Sen F, Dogan A, Landgren O, Giralt SA, Park JH, Usmani SZ, Rivière I, Brentjens RJ, Smith EL
N Engl J Med 2022 Sep 29;387(13):1196-1206. doi: 10.1056/NEJMoa2209900. PMID: 36170501Free PMC Article
Izquierdo-Serra M, Fernández-Fernández JM, Serrano M
Pflugers Arch 2020 Jul;472(7):791-809. Epub 2020 May 26 doi: 10.1007/s00424-020-02396-z. PMID: 32458086
Brodsky MC
Arch Ophthalmol 2012 Sep;130(9):1199-202. doi: 10.1001/archophthalmol.2012.2067. PMID: 22965598
Zee DS, Leigh RJ, Mathieu-Millaire F
Ann Neurol 1980 Jan;7(1):37-40. doi: 10.1002/ana.410070108. PMID: 6244772

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...