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Diffuse Neurofibrillary Tangles with Calcification

MedGen UID:
403960
•Concept ID:
C2717758
•
Mental or Behavioral Dysfunction
Synonyms: Disease, Kosaka-Shibayama; Kosaka Shibayama Disease; Kosaka-Shibayama Disease

Definition

A form of presenile DEMENTIA characterized by cortical dementia, NEUROFIBRILLARY TANGLES without SENILE PLAQUES, Fahr''s type CALCINOSIS, and ATROPHY in frontotemporal or TEMPORAL LOBE. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Neurofibrillary Tangles with Calcification

Recent clinical studies

Etiology

High frequency of calcification in basal ganglia on brain computed tomography images in Japanese older adults.
Yamada M, Asano T, Okamoto K, Hayashi Y, Kanematsu M, Hoshi H, Akaiwa Y, Shimohata T, Nishizawa M, Inuzuka T, Hozumi I
Geriatr Gerontol Int 2013 Jul;13(3):706-10. Epub 2012 Dec 21 doi: 10.1111/ggi.12004. PMID: 23279700
Distribution of basal ganglia lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of five autopsy cases.
Tsuchiya K, Nakayama H, Iritani S, Arai T, Niizato K, Haga C, Matsushita M, Ikeda K
Acta Neuropathol 2002 Jun;103(6):555-64. Epub 2002 Feb 1 doi: 10.1007/s00401-001-0501-9. PMID: 12012087

Diagnosis

Diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease) in Japan.
Ukai K, Kosaka K
Psychiatry Clin Neurosci 2016 Mar;70(3):131-40. Epub 2015 Aug 19 doi: 10.1111/pcn.12334. PMID: 26176797
Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
J Neurol Sci 2011 Feb 15;301(1-2):77-85. Epub 2010 Nov 24 doi: 10.1016/j.jns.2010.10.021. PMID: 21106208
Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification.
Ukai K, Shibayama H, Ishihara R, Ozaki N
Psychiatry Clin Neurosci 2009 Oct;63(5):646-51. Epub 2009 Jun 30 doi: 10.1111/j.1440-1819.2009.02000.x. PMID: 19570148
Argyrophilic grains are not always argyrophilic--distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods.
Uchihara T, Tsuchiya K, Nakamura A, Akiyama H
Acta Neuropathol 2005 Aug;110(2):158-64. Epub 2005 Jun 22 doi: 10.1007/s00401-005-1031-7. PMID: 15971055
Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification.
Hashimoto N, Takeuchi T, Ishihara R, Ukai K, Kobayashi H, Iwata H, Iwai K, Mizuno Y, Yamaguchi H, Shibayama H
Acta Neuropathol 2003 Aug;106(2):150-6. Epub 2003 Jun 3 doi: 10.1007/s00401-003-0715-0. PMID: 12783246

Prognosis

High frequency of calcification in basal ganglia on brain computed tomography images in Japanese older adults.
Yamada M, Asano T, Okamoto K, Hayashi Y, Kanematsu M, Hoshi H, Akaiwa Y, Shimohata T, Nishizawa M, Inuzuka T, Hozumi I
Geriatr Gerontol Int 2013 Jul;13(3):706-10. Epub 2012 Dec 21 doi: 10.1111/ggi.12004. PMID: 23279700
Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
J Neurol Sci 2011 Feb 15;301(1-2):77-85. Epub 2010 Nov 24 doi: 10.1016/j.jns.2010.10.021. PMID: 21106208

Clinical prediction guides

Clinicopathological study of diffuse neurofibrillary tangles with calcification. With special reference to TDP-43 proteinopathy and alpha-synucleinopathy.
Habuchi C, Iritani S, Sekiguchi H, Torii Y, Ishihara R, Arai T, Hasegawa M, Tsuchiya K, Akiyama H, Shibayama H, Ozaki N
J Neurol Sci 2011 Feb 15;301(1-2):77-85. Epub 2010 Nov 24 doi: 10.1016/j.jns.2010.10.021. PMID: 21106208
NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC).
Yokota O, Terada S, Ishizu H, Tsuchiya K, Kitamura Y, Ikeda K, Uéda K, Kuroda S
Acta Neuropathol 2002 Oct;104(4):333-41. Epub 2002 May 8 doi: 10.1007/s00401-002-0545-5. PMID: 12200618
Plaque-like structures and arteriosclerotic changes in "diffuse neurofibrillary tangles with calcification" (DNTC).
Terada S, Ishizu H, Tanabe Y, Takehisa Y, Haraguchi T, Hamaya K, Nose S, Sudo K, Kuroda S
Acta Neuropathol 2001 Dec;102(6):597-603. doi: 10.1007/s004010100411. PMID: 11761720
Lead content of brain tissue in diffuse neurofibrillary tangles with calcification (DNTC): the possibility of lead neurotoxicity.
Haraguchi T, Ishizu H, Takehisa Y, Kawai K, Yokota O, Terada S, Tsuchiya K, Ikeda K, Morita K, Horike T, Kira S, Kuroda S
Neuroreport 2001 Dec 21;12(18):3887-90. doi: 10.1097/00001756-200112210-00006. PMID: 11742204
Diffuse neurofibrillary tangles with calcification (a form of dementia): X-ray spectrometric evidence of lead accumulation in calcified regions.
Haraguchi T, Ishizu H, Kawai K, Tanabe Y, Uehira K, Takehisa Y, Terada S, Tsuchiya K, Ikeda K, Kuroda S
Neuroreport 2001 May 8;12(6):1257-60. doi: 10.1097/00001756-200105080-00040. PMID: 11338202

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