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Poroma

MedGen UID:: 404005
•Concept ID:: C2717981
•: Neoplastic Process

Synonyms:	Poromas; Poromatoses; Poromatosis

HPO:	HP:0031405

Definition

A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273]. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPoroma

Phenotypic abnormality
- Abnormality of the integument
  - Abnormal skin adnexa morphology
    - Skin appendage neoplasm
      - Poroma

Conditions with this feature

SchC6pf-Schulz-Passarge syndrome

MedGen UID:: 347366
•Concept ID:: C1857069
•: Disease or Syndrome

Schopf-Schulz-Passarge syndrome (SSPS) is an autosomal recessive disorder characterized by a constellation of multiple eyelid cysts, hypodontia, hypotrichosis, palmoplantar hyperkeratosis, and onychodystrophy (summary by Mallaiah and Dickinson, 2001).

See: Condition Record

SchC6pf-Schulz-Passarge syndrome

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?

Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277

Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.

Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908

Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation.

Aslan F, Demirkesen C, Cağatay P, Tüzüner N
J Cutan Pathol 2006 Aug;33(8):531-8. doi: 10.1111/j.1600-0560.2006.00466.x. PMID: 16919026

See all (3)

Recent clinical studies

Etiology

Five-year pattern of adnexal tumors of the skin in Ethiopia.

Abdullahi SM, Hailu SG, Kidane TY, Gebremariam AM, Debele YL, Degfe FZ
Int J Dermatol 2024 May;63(5):639-646. Epub 2024 Jan 4 doi: 10.1111/ijd.17009. PMID: 38174604

Combined Poroma and Verruca Plantaris.

Kneiber D, Cassarino DS
Am J Dermatopathol 2022 May 1;44(5):e51-e53. doi: 10.1097/DAD.0000000000002123. PMID: 35120031

Morphologic Diversity of Merkel Cell Carcinoma.

Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736

Poroid hidradenoma: a case report.

Delfino S, Toto V, Brunetti B, Di Marino MP, Baldi A, Persichetti P
In Vivo 2007 Sep-Oct;21(5):905-7. PMID: 18019434

Eccrine porocarcinoma with melanocyte colonization.

Nakanishi Y, Matsuno Y, Shimoda T, Wada T, Yamazaki N, Yamamoto A, Hirohashi S
Br J Dermatol 1998 Mar;138(3):519-21. doi: 10.1046/j.1365-2133.1998.02137.x. PMID: 9580812

See all (48)

Diagnosis

Eccrine Poroma: A Case Report.

Kloberdanz KR, Olenech CM, Saleh HA
J Am Podiatr Med Assoc 2023 Jan-Feb;113(1) doi: 10.7547/21-110. PMID: 36905614

Reactive syringofibroadenoma.

Kumar P, Das A, Das PC
Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):681-682. doi: 10.4103/ijdvl.IJDVL_924_18. PMID: 31249214

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Periungual eccrine poroma.

Fierro-Arias L, Calderón L, Peniche-Castellanos A, Mercadillo-Pérez P
J Cutan Med Surg 2015 Jan-Feb;19(1):84-6. Epub 2015 Jan 1 doi: 10.2310/7750.2014.14012. PMID: 25775671

Periungual porocarcinoma.

Requena L, Sánchez M, Aguilar A, Ambrojo P, Sánchez Yus E
Dermatologica 1990;180(3):177-80. doi: 10.1159/000248025. PMID: 2160378

See all (216)

Therapy

Eccrine poromatosis following chemotherapy and radiation therapy.

Nguyen K, Kim G, Chiu M
Dermatol Online J 2019 Nov 15;25(11) PMID: 32045152

Porocarcinoma: a rare sweat gland malignancy.

Asghar AH, Mahmood H, Faheem M, Rizvi S, Khan KA, Irfan J
J Coll Physicians Surg Pak 2009 Jun;19(6):389-90. PMID: 19486582

Eccrine porocarcinoma.

Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620

Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer.

Kose R, Coban YK, Ciralik H
Dermatol Online J 2006 Oct 31;12(6):18. PMID: 17083898

Treatment of advanced malignant eccrine poroma with locoregional chemotherapy.

de Bree E, Volalakis E, Tsetis D, Varthalitis Y, Panagiotidis J, Romanos J, Tsiftsis DD
Br J Dermatol 2005 May;152(5):1051-5. doi: 10.1111/j.1365-2133.2005.06472.x. PMID: 15888170

See all (12)

Prognosis

Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update.

Kervarrec T, Pissaloux D, Tirode F, de la Fouchardière A, Sohier P, Frouin E, Hamard A, Houben R, Schrama D, Barlier A, Cribier B, Battistella M, Macagno N
Histopathology 2024 Jan;84(2):266-278. Epub 2023 Aug 23 doi: 10.1111/his.15023. PMID: 37609771

Morphologic Diversity of Merkel Cell Carcinoma.

Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736

Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases.

Le NS, Janik S, Liu DT, Grasl S, Faisal M, Pammer J, Schickinger-Fischer B, Hamzavi JS, Seemann R, Erovic BM
Head Neck 2020 Sep;42(9):2644-2659. Epub 2020 Apr 21 doi: 10.1002/hed.26178. PMID: 32314845

Vulvar eccrine porocarcinoma: report of a case and literature review.

Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2017;58(4):1611-1616. PMID: 29556664

Eccrine porocarcinoma with melanocyte colonization.

Nakanishi Y, Matsuno Y, Shimoda T, Wada T, Yamazaki N, Yamamoto A, Hirohashi S
Br J Dermatol 1998 Mar;138(3):519-21. doi: 10.1046/j.1365-2133.1998.02137.x. PMID: 9580812

See all (25)