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Salivary Gland Oncocytic Adenocarcinoma

MedGen UID:: 407966
•Concept ID:: C1882974
•: Neoplastic Process

Synonym:

Salivary Gland Oncocytic Carcinoma

Definition

A high grade adenocarcinoma that arises from the salivary glands. The vast majority of cases have been described in the parotid gland. It is characterized by the presence of malignant oncocytes. It recurs and metastasizes to regional or distant anatomic sites. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSalivary Gland Oncocytic Adenocarcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Oncocytic Adenocarcinoma
        Salivary Gland Oncocytic Adenocarcinoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.

Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666 Free PMC Article

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.

Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944 Free PMC Article

See all (185)

Recent clinical studies

Etiology

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.

Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913 Free PMC Article

Major and minor salivary gland tumours.

Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526

Acinic cell carcinoma of the salivary glands: a literature review.

Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS
Hematol Oncol Stem Cell Ther 2009;2(1):259-64. doi: 10.1016/s1658-3876(09)50035-0. PMID: 20063555

See all (1504)

Diagnosis

Updated Salivary Gland Immunohistochemistry: A Review.

Swid MA, Li L, Drahnak EM, Idom H, Quinones W
Arch Pathol Lab Med 2023 Dec 1;147(12):1383-1389. doi: 10.5858/arpa.2022-0461-RA. PMID: 37074867

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.

Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK
Clin Cancer Res 2021 Feb 1;27(3):852-864. Epub 2020 Nov 10 doi: 10.1158/1078-0432.CCR-20-1192. PMID: 33172898 Free PMC Article

Mucoepidermoid carcinoma. An update and review of the literature.

Peraza A, Gómez R, Beltran J, Amarista FJ
J Stomatol Oral Maxillofac Surg 2020 Dec;121(6):713-720. Epub 2020 Jun 18 doi: 10.1016/j.jormas.2020.06.003. PMID: 32565266

See all (2357)

Therapy

Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials.

Wagner VP, Ferrarotto R, Vargas PA, Martins MD, Bingle CD, Bingle L
Crit Rev Oncol Hematol 2023 Jan;181:103886. Epub 2022 Nov 23 doi: 10.1016/j.critrevonc.2022.103886. PMID: 36427771

EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.

Sjögreen Gleisner K, Chouin N, Gabina PM, Cicone F, Gnesin S, Stokke C, Konijnenberg M, Cremonesi M, Verburg FA, Bernhardt P, Eberlein U, Gear J
Eur J Nucl Med Mol Imaging 2022 May;49(6):1778-1809. Epub 2022 Mar 14 doi: 10.1007/s00259-022-05727-7. PMID: 35284969 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma.

Tchekmedyian V, Sherman EJ, Dunn L, Tran C, Baxi S, Katabi N, Antonescu CR, Ostrovnaya I, Haque SS, Pfister DG, Ho AL
J Clin Oncol 2019 Jun 20;37(18):1529-1537. Epub 2019 Apr 2 doi: 10.1200/JCO.18.01859. PMID: 30939095 Free PMC Article

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials.

Dillon PM, Chakraborty S, Moskaluk CA, Joshi PJ, Thomas CY
Head Neck 2016 Apr;38(4):620-7. Epub 2015 Jun 16 doi: 10.1002/hed.23925. PMID: 25487882 Free PMC Article

See all (432)

Prognosis

Adolescent tongue base tumour with diagnostic histopathological dilemma.

Maiti M, Mallick A, Ghosh D, Chakrabarti I
BMJ Case Rep 2024 Aug 30;17(8) doi: 10.1136/bcr-2023-259570. PMID: 39214580

Polymorphous Adenocarcinoma.

Katabi N, Xu B
Surg Pathol Clin 2021 Mar;14(1):127-136. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.011. PMID: 33526217 Free PMC Article

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Salivary Gland Tumors: Current Concepts and Controversies.

Seethala RR
Surg Pathol Clin 2017 Mar;10(1):155-176. doi: 10.1016/j.path.2016.11.004. PMID: 28153132

The pattern of presentation of salivary gland tumors in Africa: A review of published reports.

Yaor MA
Ear Nose Throat J 2010 Feb;89(2):E17-21. PMID: 20155665

See all (1797)

Clinical prediction guides

Pediatric primary salivary gland tumors.

Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681

Microsecretory Adenocarcinoma of Salivary Glands.

Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.

Ho AS, Ochoa A, Jayakumaran G, Zehir A, Valero Mayor C, Tepe J, Makarov V, Dalin MG, He J, Bailey M, Montesion M, Ross JS, Miller VA, Chan L, Ganly I, Dogan S, Katabi N, Tsipouras P, Ha P, Agrawal N, Solit DB, Futreal PA, El Naggar AK, Reis-Filho JS, Weigelt B, Ho AL, Schultz N, Chan TA, Morris LG
J Clin Invest 2019 Oct 1;129(10):4276-4289. doi: 10.1172/JCI128227. PMID: 31483290 Free PMC Article

Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review.

Laurie SA, Ho AL, Fury MG, Sherman E, Pfister DG
Lancet Oncol 2011 Aug;12(8):815-24. Epub 2010 Dec 10 doi: 10.1016/S1470-2045(10)70245-X. PMID: 21147032

See all (1131)

Recent systematic reviews

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.

Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810

A systematic review of secretory carcinoma of the salivary gland: where are we?

Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686

Prognostic value of CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma: Systematic review and meta-analysis.

Pérez-de-Oliveira ME, Wagner VP, Araújo ALD, Martins MD, Santos-Silva AR, Bingle L, Vargas PA
J Oral Pathol Med 2020 May;49(5):386-394. Epub 2019 Nov 16 doi: 10.1111/jop.12970. PMID: 31661572

Merkel cell carcinoma: a systematic review of ENT presentations.

Gioacchini FM, Postacchini V, Simonetti O, Offidani A, Magliulo G, Re M
Eur Arch Otorhinolaryngol 2013 Aug;270(8):2191-9. Epub 2012 Nov 29 doi: 10.1007/s00405-012-2283-1. PMID: 23192664

Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review.

Laurie SA, Ho AL, Fury MG, Sherman E, Pfister DG
Lancet Oncol 2011 Aug;12(8):815-24. Epub 2010 Dec 10 doi: 10.1016/S1470-2045(10)70245-X. PMID: 21147032

See all (43)

MedGen

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Salivary Gland Oncocytic Adenocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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